Role of mesenchymal stem cell-derived microvesicles in tissue repair

Bruno, Stefania; Camussi, Giovanni

doi:10.1007/s00467-013-2413-z

Cited by 61 publications

(56 citation statements)

References 51 publications

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“…Previous studies demonstrated that EVs produced by bone-marrow derived MSCs contribute to tissue remodeling after injury [12]. In the present study we focused on the angiogenic potential of EVs derived from ASCs that may represent a suitable source of adult stem cells for regenerative medicine.…”

Section: Discussionmentioning

confidence: 99%

“…ASC conditioned medium contains several growth factors including vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) and may mimic the beneficial effects of cells [10,11]. We previously found that EVs released from stem/progenitor cells may, at least in part, account for the effect of conditioned medium [12]. EVs derived from endothelial progenitor cells were shown to activate an angiogenic program in quiescent endothelial cells [13].…”

Section: Introductionmentioning

confidence: 99%

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Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential

et al. 2014

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BackgroundSeveral studies demonstrate the role of adipose mesenchymal stem cells (ASCs) in angiogenesis. The angiogenic mechanism has been ascribed to paracrine factors since these cells secrete a plenty of signal molecules and growth factors. Recently it has been suggested that besides soluble factors, extracellular vesicles (EVs) that include exosomes and microvesicles may play a major role in cell-to-cell communication. It has been shown that EVs are implicated in the angiogenic process.ResultsHerein we studied whether EVs released by ASCs may mediate the angiogenic activity of these cells. Our results demonstrated that ASC-derived EVs induced in vitro vessel-like structure formation by human microvascular endothelial cells (HMEC). EV-stimulated HMEC when injected subcutaneously within Matrigel in SCID mice formed vessels. Treatment of ASCs with platelet-derived growth factor (PDGF) stimulated the secretion of EVs, changed their protein composition and enhanced the angiogenic potential. At variance of EVs released in basal conditions, PDGF-EVs carried c-kit and SCF that played a role in angiogenesis as specific blocking antibodies inhibited in vitro vessel-like structure formation. The enhanced content of matrix metalloproteinases in PDGF-EVs may also account for their angiogenic activity.ConclusionsOur findings indicate that EVs released by ASCs may contribute to the ASC-induced angiogenesis and suggest that PDGF may trigger the release of EVs with an enhanced angiogenic potential.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential

et al. 2014

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“…Transfer of this biological material to adjacent or distant cells may facilitate communication between different cell types. Secreted EVs express molecules that reflect the cells of origin and, in the field of regenerative medicine, EVs derived from MSCs (MSC-EVs) have been shown to be able to mimic the therapeutic effects of the MSCs in kidney, cardiac, and brain injuries (29, 30). EVs released from MSCs could also be involved in the effects of MSCs on tumor growth and behavior.…”

Section: Introductionmentioning

confidence: 99%

Effects of Mesenchymal Stromal Cell-Derived Extracellular Vesicles on Tumor Growth

et al. 2014

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Extracellular vesicles (EVs) are membrane vesicles, which are secreted by a variety of cells that have a relevant role in intercellular communication. EVs derived from various cell types exert different effects on target cells. Mesenchymal stromal cells (MSCs) are stem cells that are ubiquitously present in different tissues of the human body, and MSC-derived EVs take part in a wide range of biological processes. Of particular relevance is the effect of MSCs on tumor growth and progression. MSCs have opposing effects on tumor growth, being able either to favor angiogenesis and tumor initiation, or to inhibit progression of established tumors, according to the conditions. Different studies have reported that EVs from MSCs may exert either an anti- or a pro-tumor growth effect depending on tumor type and stage of development. In this review, we will discuss the data presented in the literature on EV-mediated interactions between MSCs and tumors.

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“…These classical biomarkers have poor sensitivity and specificity for the detection of renal injury [16]. Moreover, the infusion of stem cells is replaced by a new approach that consists in administering vesicles obtained from cultured stem cells [17] or proteins/genetic material obtained from microvesicles [18].…”

Section: Expert Opinionmentioning

confidence: 99%

Biomarkers and personalized therapy in chronic kidney diseases

Schena

2014

Expert Opinion on Investigational Drugs

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Role of mesenchymal stem cell-derived microvesicles in tissue repair

Cited by 61 publications

References 51 publications

Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential

Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential

Effects of Mesenchymal Stromal Cell-Derived Extracellular Vesicles on Tumor Growth

Biomarkers and personalized therapy in chronic kidney diseases

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