Role of Memantine in Limiting Cochleotoxicity in Rats
Pavlos Pavlidis,
Vasilis Spyridon Tseriotis,
Kyriaki Papadopoulou
et al.
Abstract:AbstractΟur aim was to test whether amikacin’s well-known cochleotoxic effects could be suppressed, depending on whether an NMDA-antagonist (memantine) was administered simultaneously with or after amikacin treatment. Forty Wistar rats were used in this experiment. Ten rats acted as controls and received no medication (group A). Amikacin (200 mg/kg) was administered intraperitoneally (i.p.) once daily for 14 days to 10 animals in group B; amikacin (200 mg/kg) was administered concurrently with memantine (10 mg… Show more
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