Role of melatonin on electromagnetic radiation-induced oxidative stress and Ca²⁺signaling molecular pathways in breast cancer

Abstract

Melatonin may modulate breast cancer through modulation of enhanced oxidative stress and Ca(2+) influx in cell lines. However, there is not enough evidence on increased risk of breast cancer related to EMR exposure.

Melatonin affects voltage-dependent calcium and potassium currents in MCF-7 cell line cultured either in growth or differentiation medium

“…In relation to I Ca , our findings demonstrate that melatonin treatment was able to reduce both T-and L-type Ca 2 þ current amplitude and to provoke an alteration of the current voltage dependence along with a decrease of intracellular Ca 2 þ concentration. Since Ca 2 þ seems to be a crucial regulator of the cell cycle necessary for proper proliferation (Bertolesi et al, 2002;Gray et al, 2004;Naziroğlu et al, 2012;Wang et al, 2000), the associated reduction of free [Ca 2 þ ] i observed in our experiments supports the clue that melatonin may contribute to the decline of proliferation also disturbing internal Ca 2 þ homeostasis. The G-protein-coupled melatonin MT1 receptors are expressed in MCF-7 cells (Girgert et al, 2009;Hill et al, 2011b;Jablonska et al, 2013;Jawed et al, 2007;Rich et al, 1999) and, via the inhibition of adenylate cyclase activity (Jablonska et al, 2013;Jawed et al, 2007), their activation leads to the decrease of adenosine 3 0 , 5 0 -cyclic monophosphate (cAMP) synthesis.…”

Melatonin increased vitamin C and antioxidant enzyme values in the plasma,heart, liver, and kidney of Adriamycin-treated rats

“…One practice used for minimizing the oxidative stress induced by Adriamycin is the administration of some antioxidants to experimental animals. Melatonin, an important natural antioxidant, may reduce oxidative stress induced by Adriamycin (Othman et al, 2008) and other stimulative agents (Naziroğlu et al, 2012, Senol et al, 2014. It has been reported that Adriamycin affected the activities of CAT, SOD, GSH-Px, and GR in experimental animals (Özdoğan et al, 2011;Lee et al, 2013;Zang et al, 2013).…”

Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

“…Circulating melatonin levels were found to be abnormally low in ER-positive breast cancer patients [294]. Melatonin may modulate breast cancer through modulation of enhanced oxidative stress and Ca 2+ influx in cell lines [295]. Suppression of melatonin by light or melatonin deficiency plays a major role in cancer development.…”