Role of melatonin in UV‐B signaling pathway and UV‐B stress resistance in <scp><i>Arabidopsis thaliana</i></scp>

Yao, Jing-Wen; Ma, Zheng; Ma, Ying; Zhu, Ying; Lei, Meng-Qi; Hao, Cheng-Ying; Chen, Liyu; Xu, Zi-Qin; Huang, Xuan

doi:10.1111/pce.13879

Cited by 54 publications

(28 citation statements)

References 67 publications

(92 reference statements)

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“…The function of melatonin in plants has been widely reported ( Fan et al, 2018 ; Sun et al, 2020 ). It can respond to various biotic ( Mandal et al, 2018 ; Zhao et al, 2021 ) and abiotic ( Chen et al, 2017 ; Yao et al, 2020 ) stresses to resist the influence of environmental changes during plant growth and development. The immune response of melatonin in plants requires the participation of many signaling molecules, such as reactive oxygen species (ROS; Pardo-Hernández et al, 2020 ) and Nitric Oxide (NO; Zhu et al, 2019 ), to transmit both intracellular and intercellular signals.…”

Section: Introductionmentioning

confidence: 99%

Roles of Endogenous Melatonin in Resistance to Botrytis cinerea Infection in an Arabidopsis Model

et al. 2021

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Melatonin is an important bioactive molecule in plants. Two synthetases, N-acetylserotonin methyltransferase (ASMT) and serotonin N-acetyltransferase (SNAT) are involved in the final two steps of melatonin synthesis. Melatonin participates in responses to a variety of biotic and abiotic stresses in plants, but few studies have addressed the roles of endogenous melatonin in pathogen resistance. We investigated the role of endogenous melatonin in resistance to Botrytis cinerea infection in an Arabidopsis thaliana model system. Plant lines that overexpressed ASMT or SNAT through genetic manipulation showed upregulated expression of resistance genes PR1 and PR5, transcription factor gene WRKY33, and jasmonic acid (JA) defense pathway marker gene PDF1.2, and downregulated transcription factor gene MYC2 in JA signaling pathway. Higher melatonin content also enhanced the activity of antioxidant enzymes superoxide dismutase (SOD) and peroxidase (POD), increased JA content, reduced plant disease symptoms, and reduced lesion size in leaves. These findings indicate that endogenous melatonin enhances plant resistance to B. cinerea infection. In contrast, ASMT and SNAT gene silencing lines showed opposite results and were more susceptible to B. cinerea. Thus, it can be demonstrated that melatonin functions as an effective regulator of plant stress resistance at the genetic level. A schematic model is presented for its role in resistance to B. cinerea infection. Our findings also helped to elucidate the associated signal transduction pathways and interactions between melatonin and other plant hormones.

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Section: Introductionmentioning

confidence: 99%

Roles of Endogenous Melatonin in Resistance to Botrytis cinerea Infection in an Arabidopsis Model

et al. 2021

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“…At the same time, melatonin increased the activity of antioxidant enzymes, thus enhancing the tolerance of plants to high light. In addition, Yao et al (2020) reported the synthesis of melatonin was induced by UV-B. The wavelength of light spectrum also affected the synthesis of melatonin.…”

Section: Introductionmentioning

confidence: 99%

Melatonin Enhanced the Tolerance of Arabidopsis thaliana to High Light Through Improving Anti-oxidative System and Photosynthesis

et al. 2021

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Land plants live in a crisis-filled environment and the fluctuation of sunlight intensity often causes damage to photosynthetic apparatus. Phyto-melatonin is an effective bioactive molecule that helps plants to resist various biotic and abiotic stresses. In order to explore the role of melatonin under high light stress, we investigated the effects of melatonin on anti-oxidative system and photosynthesis of Arabidopsis thaliana under high light. Results showed that exogenous melatonin increased photosynthetic rate and protected photosynthetic proteins under high light. This was mainly owing to the fact that exogenous melatonin effectively decreased the accumulation of reactive oxygen species and protected integrity of membrane and photosynthetic pigments, and reduced cell death. Taken together, our study promoted more comprehensive understanding in the protective effects of exogenous melatonin under high light.

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“…Melatonin has previously been hypothesized to mediate plant responses through the constitutively overexpressed photomorphogenesis (COP)9 signalosome (Sanchez- Barcelo et al, 2016), an important mediator of ubiquitination and light-induced development or photomorphogenesis in plants. A recent in-depth study in Arabidopsis further supports this hypothesis showing that not only is the melatonin biosynthetic pathway upregulated and subsequently melatonin accumulated under UV-B exposure, but that melatonin mediated responses to UV-B exposure involves interactions with COP1 and the transcription factors HYH and HY5 (Yao et al, 2021). Though the mechanism is not well understood, the authors hypothesize that UV-B receptor 8 (UVR8), the UV-B receptor, binds to COP1 activating HY5 and HYH and their downstream gene regulation networks (Yao et al, 2021).…”

Section: Major Research Theme -Light Responsesmentioning

confidence: 77%

“…A recent in-depth study in Arabidopsis further supports this hypothesis showing that not only is the melatonin biosynthetic pathway upregulated and subsequently melatonin accumulated under UV-B exposure, but that melatonin mediated responses to UV-B exposure involves interactions with COP1 and the transcription factors HYH and HY5 (Yao et al, 2021). Though the mechanism is not well understood, the authors hypothesize that UV-B receptor 8 (UVR8), the UV-B receptor, binds to COP1 activating HY5 and HYH and their downstream gene regulation networks (Yao et al, 2021). It is unclear where in this pathway melatonin is acting, as both Arabidopsis cop1 and hy5 mutants show decreased responses to UV-B exposure, however, this is particularly interesting since the chromophore in the UVR8 receptor is a series of repeating tryptophan residues (Lee, 2016).…”

Section: Major Research Theme -Light Responsesmentioning

confidence: 77%

A Systematic Review of Melatonin in Plants: An Example of Evolution of Literature

Murch

Erland

2021

Front. Plant Sci.

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Melatonin (N-acetyl-5-methoxy-tryptamine) is a mammalian neurohormone, antioxidant and signaling molecule that was first discovered in plants in 1995. The first studies investigated plant melatonin from a human perspective quantifying melatonin in foods and medicinal plants and questioning whether its presence could explain the activity of some plants as medicines. Starting with these first handful of studies in the late 1990s, plant melatonin research has blossomed into a vibrant and active area of investigation and melatonin has been found to play critical roles in mediating plant responses and development at every stage of the plant life cycle from pollen and embryo development through seed germination, vegetative growth and stress response. Here we have utilized a systematic approach in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) protocols to reduce bias in our assessment of the literature and provide an overview of the current state of melatonin research in plants, covering 1995–2021. This review provides an overview of the biosynthesis and metabolism of melatonin as well as identifying key themes including: abiotic stress responses, root development, light responses, interkingdom communication, phytohormone and plant signaling. Additionally, potential biases in the literature are investigated and a birefringence in the literature between researchers from plant and medical based which has helped to shape the current state of melatonin research. Several exciting new opportunities for future areas of melatonin research are also identified including investigation of non-crop and non-medicinal species as well as characterization of melatonin signaling networks in plants.

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Role of melatonin in UV‐B signaling pathway and UV‐B stress resistance in Arabidopsis thaliana

Cited by 54 publications

References 67 publications

Roles of Endogenous Melatonin in Resistance to Botrytis cinerea Infection in an Arabidopsis Model

Roles of Endogenous Melatonin in Resistance to Botrytis cinerea Infection in an Arabidopsis Model

Melatonin Enhanced the Tolerance of Arabidopsis thaliana to High Light Through Improving Anti-oxidative System and Photosynthesis

A Systematic Review of Melatonin in Plants: An Example of Evolution of Literature

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