Role of melatonin in the treatment of COVID-19; as an adjuvant through cluster differentiation 147 (CD147)

Şehirli, Ahmet Özer; Sayıner, Serkan; Serakıncı, Nedime

doi:10.1007/s11033-020-05830-8

Cited by 47 publications

(51 citation statements)

References 67 publications

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“…178 179 Melatonin also inhibits calmodulin, which increases ACE2 expression and retention on the cell surface. 180 181 Melatonin might also block CD147, 182 which is another cellular receptor for of SARS-CoV-2 entry 183 and involved in regulating chemotaxis and lung inflammation. 184 Furthermore, in silico studies suggest that melatonin inhibits SARS-CoV-2's main protease.…”

Section: Higher Levels Of Melatoninmentioning

confidence: 99%

Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections

2020

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In contrast to other respiratory viruses, children have less severe symptoms when infected with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this review, we discuss proposed hypotheses for the age-related difference in severity of coronavirus disease 2019 (COVID-19).Factors proposed to explain the difference in severity of COVID-19 in children and adults include those that put adults at higher risk and those that protect children. The former include: (1) age-related increase in endothelial damage and changes in clotting function; (2) higher density, increased affinity and different distribution of angiotensin converting enzyme 2 receptors and transmembrane serine protease 2; (3) pre-existing coronavirus antibodies (including antibody-dependent enhancement) and T cells; (4) immunosenescence and inflammaging, including the effects of chronic cytomegalovirus infection; (5) a higher prevalence of comorbidities associated with severe COVID-19 and (6) lower levels of vitamin D. Factors that might protect children include: (1) differences in innate and adaptive immunity; (2) more frequent recurrent and concurrent infections; (3) pre-existing immunity to coronaviruses; (4) differences in microbiota; (5) higher levels of melatonin; (6) protective off-target effects of live vaccines and (7) lower intensity of exposure to SARS-CoV-2.

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Section: Higher Levels Of Melatoninmentioning

confidence: 99%

Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections

2020

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“…Accompanied by all these findings, it is understood that 5-MTX, which is released in light with the dark hormone melatonin, plays a protective role on the body with its antioxidant and immunomodulatory effect for 24 h. Although studies are emphasizing that melatonin can be effective on COVID-19 [23] , 5-MTX has no studies on COVID-19. In light of current bibliography, maintaining a balanced light-dark cycle of the patient, thus keep 5-MTX levels normal during COVID-19 is likely to accelerate the recovery of the patient by preventing the cytokine storm.…”

Section: Resultsmentioning

confidence: 99%

Daylight is critical to preserve 5-methoxytryptophol levels in suspected and confirmed COVID-19 patients

Şehirli

Sayıner

2021

Medical Hypotheses

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“…The melatonin also acts by inhibition of calmodulin in association of an increased presence of ACE2 by enhancing its binding on the cell surface, which represents the host cell receptor for SARS-CoV-2 [ 223 ]. The melatonin may also block CD147, another cellular receptor for SARS-CoV-2 involved in the regulation of chemotaxis and lung inflammation [ 224 ].…”

Section: Melatonin Supplement For Covid-19mentioning

confidence: 99%

SARS-CoV-2 Disease Adjuvant Therapies and Supplements Breakthrough for the Infection Prevention

Inchingolo

Bordea

et al. 2021

Microorganisms

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The SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a high-risk viral agent involved in the recent pandemic stated worldwide by the World Health Organization. The infection is correlated to a severe systemic and respiratory disease in many cases, which is clinically treated with a multi-drug pharmacological approach. The purpose of this investigation was to evaluate through a literature overview the effect of adjuvant therapies and supplements for the SARS-CoV-2 infection. The research has analyzed the advantage of the EK1C4, by also assessing the studies on the resveratrol, vitamin D, and melatonin as adjuvant supplements for long hauler patients’ prognosis. The evaluated substances reported important benefits for the improvement of the immune system and as a potential inhibitor molecules against SARS-CoV-2, highlighting the use of sartans as therapy. The adjuvant supplements seem to create an advantage for the healing of the long hauler patients affected by chronic symptoms of constant chest and heart pain, intestinal disorders, headache, difficulty concentrating, memory loss, and tachycardia.

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Role of melatonin in the treatment of COVID-19; as an adjuvant through cluster differentiation 147 (CD147)

Cited by 47 publications

References 67 publications

Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections

Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections

Daylight is critical to preserve 5-methoxytryptophol levels in suspected and confirmed COVID-19 patients

SARS-CoV-2 Disease Adjuvant Therapies and Supplements Breakthrough for the Infection Prevention

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