Role of Medicinal Plants in the Management of Diabetes Mellitus: A Review

Abstract

Diabetes mellitus is a worse metabolic condition in which level of glucose and lipid increased in blood circulation due to insufficient insulin functionality that may lead to worse the complication like atherosclerosis, dyslipidemia, gangrene, limb amputation, kidney failure, and many more. Furthermore, high concentration of glucose in blood stream can directly produce reactive oxygen species which ultimately more worsen the conditions like dyslipidemia, atherosclerosis etc. This disorder is expected to affect 9.3% of the global population in 2019, increasing to 10.2% by 2030 and increasing 10.9 % by 2045. Medicinal plants are used as medicine to treat many ailments since a long time ago. But now they have been rediscovered with having specific constituents to treat diseases and many more yet to discover. There are so many active phytoconstituents of plants which are being extracted, purified, tested and formulated for patient convenience. In the present review, various plants used to treat diabetes mellitus due to have negligible side effects as compared to allopathic treatment (oral hypoglycemic drugs) are described. Many plants with hypoglycemic effect of many plants have been reported, and the mechanisms of action of these plants with these hypoglycemic behaviors are being examined through in vitro and in vivo studies. Some of these 22 medicinal plants and their active constituents related to antidiabetic activity are discussed in this review.

Obesity Model in White Male Wistar Rats: The Impact of Moringa (Moringa Oleifera) Flower Extract on Pancreatic Function as Deduced from Serum Amylase and Lipase Levels and the Histopathological Image of the Pancreas

“…Plant chemicals can be classified into several broad groups: alkaloids, aromatic acids, carotenoids, coumarins, essential oils, flavonoids, glycosides, organic acids, phenols and phenolics, phytosterols, saponins, steroids, tannins, terpenes, and terpenoids. Vitamins and medicinal plants have recently been found to have anti-diabetic, anti-hyperglycemic, anti-lipidemic, hypoglycemic, and insulin-mimicking effects in pharmacological trials [19], [20]. Moringa oleifera is one plant that has the potential to treat diabetes.…”

The Management of Diabetes Mellitus Using Medicinal Plants and Vitamins

“…The major groups of phytochemicals are alkaloids, aromatic acids, carotenoids, coumarins, essential oils, flavonoids, glycosides, organic acid, phenols and phenolics, phytosterols, protease inhibitors, saponins, steroids, tannins, terpenes, and terpenoids [21][22][23]. Recent pharmacological studies have revealed the anti-diabetic properties of medicinal plants and vitamins including anti-hyperglycemic, anti-lipidemic, hypoglycemic, and insulin mimicking [24,25]. The treatment strategies for DM have improved over the last few decades.…”

In vivo and in silicoexperiment onMitragyna speciosaoffers new insight of antidiabetic potentials

“…The antidiabetic phytochemicals have been identified based on the differences in their chemical structures [18], [19]. Some of the major classes of phytochemicals are Alkaloids, aromatic acids, carotenoids, coumarins, essential oils, flavonoids, glycosides, organic acids, phenols and phenolics, phytosterols, protease inhibitors, saponins, steroids, tannins, terpenes, and terpenoids [20]- [24].…”