Role of Medicinal plant‐derived Nutraceuticals as a potential target for the treatment of breast cancer

Abstract

Breast cancer (BC) is one of the most challenging cancers to treat, accounting for many cancer‐related deaths. Over some years, chemotherapy, hormone treatment, radiation, and surgeries have been used to treat cancer. Unfortunately, these treatment options are unsuccessful due to crucial adverse reactions and multidrug tolerance/resistance. Although it is clear that substances in the nutraceuticals category have a lot of anti‐cancer activity, using a supplementary therapy strategy, in this case, could be very beneficial. Nutraceuticals are therapeutic agents, which are nutrients that have drug‐like characteristics and can be used to treat diseases. Plant nutraceuticals categorized into polyphenols, terpenoids, vitamins, alkaloids, and flavonoids are part of health food products, that have great potential for combating BC. Nutraceuticals can reduce BC's severity, limit malignant cell growth, and modify cancer‐related mechanisms. Nutraceuticals acting by attenuating Hedgehog, Nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB), Notch, and Wnt/β‐catenin signaling are the main pathways in controlling the self‐renewal of breast cancer stem cells (BCSCs). This article reviews some important nutraceuticals and their modes of action, which can be very powerful versus BC. Practical applications Nutraceuticals' importance to the control and diagnosis of breast cancer is undeniable and cannot be overlooked. Natural dietary compounds have a wide range of uses and have been used in traditional medicine. In addition, these natural chemicals can enhance the effectiveness of other traditional medicines. They may also be used as a treatment process independently because of their capacity to affect several cancer pathways. This study highlights a variety of natural chemicals, and their mechanisms of action, routes, synergistic effects, and future potentials are all examined.

Exploring the Antioxidant Potential of Talisia esculenta Using In Vitro and In Vivo Approaches

“…As a result of the presence of different bioactive molecules in medicinal plants, their preparation as teas, hydroethanolic extracts, or supplements may be considered as an alternative therapeutic and nutraceutical approach [58][59][60]. Thus, the search for different antioxidant nutraceuticals, as medicinal plants, whose use can supplement phytochemical intake and promote human health, has intensified [61][62][63]. Moreover, the recently obtained scientific data have shown that continuous pharmacological screening of different plants extracts is still an important step towards the development of new natural products, phytotherapeutics, and nutraceuticals to be used for the prevention and treatment of diseases [64].…”

Value Addition Employing Waste Bio-Materials in Environmental Remedies and Food Sector

“…These products can easily extract bioactive substances like prebiotics or antioxidant metabolites [ 45 ]. In the analysis of FW’s metabolomics profile, few studies have been conducted to produce vinegar and wine from pineapple pulp and peel characterized by GC-MS and ultra-high performance liquid chromatography (UHPLC) hyphenated with quadrupole-time-of-flight tandem mass spectrometry (UHPLC-QTOF-MS) [ 46 ], essential oils from plants in the genus Lavandula, mainly L. intermedia and L. angustifolia , functional foods and nutraceuticals from by-products of Vicia faba beans, and supplements with therapeutic uses from Passiflora mollissima seeds confirmed by using (UHPLC-QTOF-MS) [ 47 , 48 , 49 ]. Using a different technique, like nuclear magnetic resonance (NMR)-based metabolomics analysis revealed alterations in primary and secondary metabolites (e.g., amino acids, carbohydrates, and phenolics) in banana fruits during postharvest senescence [ 50 ].…”

Phyto-therapeutics as anti-cancer agents in breast cancer: Pathway targeting and mechanistic elucidation

“…One of the best ways to combat cancer, including breast cancer, among the various therapeutic options currently accessible, is to use chemical formulations or chemicals derived from natural sources. Currently on the market, almost 60 % of cancer medications come from natural sources ( Alharbi et al, 2022 ). Phytochemicals have few side effects and a high cancer effectiveness.…”