Role of mechano-sensitive non-coding RNAs in bone remodeling of orthodontic tooth movement: recent advances

Yan, Lei; Liao, Li; Su, Xiaoxia

doi:10.1186/s40510-022-00450-3

Cited by 8 publications

(4 citation statements)

References 178 publications

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“…ncRNAs are crucial biological factors and are acknowledged as a revolution for disease management in mechanism research, drug development, and the invention of new biomaterials. ncRNAs have a regulatory role during various phases of the bone remodeling process as reported in various studies (Yan et al, 2022).…”

Section: Regulation Of Osteoclastogenesismentioning

confidence: 87%

Fine‐tuning osteoclastogenesis: An insight into the cellular and molecular regulation of osteoclastogenesis

Anwar

Sapra

Gupta

et al. 2023

Journal Cellular Physiology

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Osteoclasts, the bone-resorbing cells, are essential for the bone remodeling process and are involved in the pathophysiology of several bone-related diseases. The extensive corpus of in vitro research and crucial mouse model studies in the 1990s demonstrated the key roles of monocyte/macrophage colony-stimulating factor, receptor activator of nuclear factor kappa B ligand (RANKL) and integrin αvβ3 in osteoclast biology. Our knowledge of the molecular mechanisms by which these variables control osteoclast differentiation and function has significantly advanced in the first decade of this century. Recent developments have revealed a number of novel insights into the fundamental mechanisms governing the differentiation and functional activity of osteoclasts; however, these mechanisms have not yet been adequately documented. Thus, in the present review, we discuss various regulatory factors including local and hormonal factors, innate as well as adaptive immune cells,noncoding RNAs (ncRNAs), etc., in the molecular regulation of the intricate and tightly regulated process of osteoclastogenesis. ncRNAs have a critical role as epigenetic controllers of osteoclast physiologic activities, including differentiation and bone resorption. The primary ncRNAs, which include micro-RNAs, circular RNAs, and long noncoding RNAs, form a complex network that affects gene transcription activities associated with osteoclast biological activity. Greater knowledge of the involvement of ncRNAs in osteoclast biological activities will contribute to the treatment and management of several skeletal diseases such as osteoporosis, osteoarthritis, rheumatoid arthritis, etc. Moreover, we further outline potential therapies targeting these regulatory pathways of osteoclastogenesis in distinct bone pathologies.

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Section: Regulation Of Osteoclastogenesismentioning

confidence: 87%

Fine‐tuning osteoclastogenesis: An insight into the cellular and molecular regulation of osteoclastogenesis

Anwar

Sapra

Gupta

et al. 2023

Journal Cellular Physiology

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“…These lncRNAs promote osteogenic differentiation by various mechanisms, such as acting as sponges for miRNAs or regulating key osteogenic factors. On the other hand, some lncRNAs negatively regulate osteogenic differentiation, including HOTAIR, 105 ODIR1, 106 SNHG1, 107 UCA1, 108 and more. These lncRNAs inhibit osteogenesis by suppressing specific signaling pathways or inhibiting the expression of osteogenic marker genes.…”

Section: Overview Of Epigenetic Modificationsmentioning

confidence: 99%

Epigenetic Regulation of Autophagy in Bone Metabolism

Zhang,

Wang,

Xue

et al. 2024

Function

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The skeletal system is crucial for supporting bodily functions, protecting vital organs, facilitating hematopoiesis, and storing essential minerals. Skeletal homeostasis, which includes aspects like bone density, structural integrity, and regenerative processes, is essential for normal skeletal function. Autophagy, an intricate intracellular mechanism for degrading and recycling cellular components, plays a multifaceted role in bone metabolism. It involves sequestering cellular waste, damaged proteins, and organelles within autophagosomes, which are then degraded and recycled. Autophagy's impact on bone health varies depending on factors such as regulation, cell type, environmental cues, and physiological context. Despite being traditionally considered a cytoplasmic process, autophagy is subject to transcriptional and epigenetic regulation within the nucleus. However, the precise influence of epigenetic regulation, including DNA methylation, histone modifications, and non-coding RNA (ncRNA) expression, on cellular fate remains incompletely understood. The interplay between autophagy and epigenetic modifications adds complexity to bone cell regulation. This article provides an in-depth exploration of the intricate interplay between these two regulatory paradigms, with a focus on the epigenetic control of autophagy in bone metabolism. Such an understanding enhances our knowledge of bone metabolism-related disorders and offers insights for the development of targeted therapeutic strategies.

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“…A study found that miR-29 is downregulated in the gingival tissue of individuals with skeletal Class I occlusion and that this downregulation is associated with an increase in the expression of the target genesCOL1A1 and MMP13, which are involved in the regulation of bone remodeling [55]. In addition, miR-31 is downregulated in the gingival tissue of individuals with skeletal Class I occlusion, and this downregulation is associated with an increase in the expression of the target geneTWIST1, which is involved in regulating craniofacial development [56].…”

Section: Rna Alterations In Skeletal Class I Occlusionmentioning

confidence: 99%

Narrating the Genetic Landscape of Human Class I Occlusion: A Perspective-Infused Review

Lone,

Zohud,

Midlej

et al. 2023

JPM

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This review examines a prevalent condition with multifaceted etiology encompassing genetic, environmental, and oral behavioral factors. It stands as a significant ailment impacting oral functionality, aesthetics, and quality of life. Longitudinal studies indicate that malocclusion in primary dentition may progress to permanent malocclusion. Recognizing and managing malocclusion in primary dentition is gaining prominence. The World Health Organization ranks malocclusions as the third most widespread oral health issue globally. Angle’s classification system is widely used to categorize malocclusions, with Class I occlusion considered the norm. However, its prevalence varies across populations due to genetic and examination disparities. Genetic factors, including variants in genes like MSX1, PAX9, and AXIN2, have been associated with an increased risk of Class I occlusion. This review aims to provide a comprehensive overview of clinical strategies for managing Class I occlusion and consolidate genetic insights from both human and murine populations. Additionally, genomic relationships among craniofacial genes will be assessed in individuals with Class I occlusion, along with a murine model, shedding light on phenotype–genotype associations of clinical relevance. The prevalence of Class I occlusion, its impact, and treatment approaches will be discussed, emphasizing the importance of early intervention. Additionally, the role of RNA alterations in skeletal Class I occlusion will be explored, focusing on variations in expression or structure that influence craniofacial development. Mouse models will be highlighted as crucial tools for investigating mandible size and prognathism and conducting QTL analysis to gain deeper genetic insights. This review amalgamates cellular, molecular, and clinical trait data to unravel correlations between malocclusion and Class I phenotypes.

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Role of mechano-sensitive non-coding RNAs in bone remodeling of orthodontic tooth movement: recent advances

Cited by 8 publications

References 178 publications

Fine‐tuning osteoclastogenesis: An insight into the cellular and molecular regulation of osteoclastogenesis

Fine‐tuning osteoclastogenesis: An insight into the cellular and molecular regulation of osteoclastogenesis

Epigenetic Regulation of Autophagy in Bone Metabolism

Narrating the Genetic Landscape of Human Class I Occlusion: A Perspective-Infused Review

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