Role of matrix metalloproteinases in mitral valve regurgitation: Association between the of MMP‐1, MMP‐9, TIMP‐1, and TIMP‐2 expression, degree of mitral valve insufficiency, and pathologic etiology

Abstract

To the Editor, We read with great interest your article named "Role of matrix metalloproteinases in mitral valve regurgitation: Association between the of MMP-1, MMP-9, TIMP-1, and TIMP-2 expression, degree of mitral valve insufficiency, and pathologic etiology." 1 The article is competent and well written. We concur with the findings that a clear correlation between the matrix metalloproteinases (MMPs) expression and the mitral insufficiency exists which also corresponds with the degree of severity. However, after thoroughly reviewing your article, there are a few ideas worth discussing that could enhance the quality of the overall article.