Role of maternal interleukin-8 (IL-8) in normal-term birth in the human

Ehsani, Vahid; Mortazavi, Maryam; Ghorban, Khodayar; Dadmanesh, Maryam; Bahramabadi, Reza; Rezayati, Mohammad Taghi; Javadi-Moghadam, Esmat; Rezaei, Zahra; Sabzali, Zahra; Fatemi, Iman; Fathollahi, Mahmood Sheikh; Arababadi, Mohammad Kazemi

doi:10.1071/rd18361

Cited by 14 publications

(11 citation statements)

References 26 publications

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“…One reason may be the seemingly chaotic cytokine expression and immunological regulation in late term pregnancies. In contrast to our results of cytokine upregulation in late term pregnancies, decreased or unchanged levels of IL-6, IL-8 and TNF-α has been associated with prolonged pregnancy ( 88 ), including all pregnancies beyond 40 +0 weeks. However, IL-8 was related to the induction of labor, consistent with our findings ( 88 ).…”

Section: Discussioncontrasting

confidence: 99%

“…In contrast to our results of cytokine upregulation in late term pregnancies, decreased or unchanged levels of IL-6, IL-8 and TNF-α has been associated with prolonged pregnancy ( 88 ), including all pregnancies beyond 40 +0 weeks. However, IL-8 was related to the induction of labor, consistent with our findings ( 88 ). Most of the cytokines of high importance to the prediction model have been related to preterm labor in earlier studies ( 89 ), indicating that this cytokine pattern is associated with labor regardless of when in pregnancy the labor takes place.…”

Section: Discussioncontrasting

confidence: 99%

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Cytokine Patterns in Maternal Serum From First Trimester to Term and Beyond

et al. 2021

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Pregnancy implies delicate immunological balance between two individuals, with constant changes and adaptions in response to maternal capacity and fetal demands. We performed cytokine profiling of 1149 longitudinal serum samples from 707 pregnant women to map immunological changes from first trimester to term and beyond. The serum levels of 22 cytokines and C-reactive protein (CRP) followed diverse but characteristic trajectories throughout pregnancy, consistent with staged immunological adaptions. Eotaxin showed a particularly robust decrease throughout pregnancy. A strong surge in cytokine levels developed when pregnancies progressed beyond term and the increase was amplified as labor approached. Maternal obesity, smoking and pregnancies with large fetuses showed sustained increase in distinct cytokines throughout pregnancy. Multiparous women had increased cytokine levels in the first trimester compared to nulliparous women with higher cytokine levels in the third trimester. Fetal sex affected first trimester cytokine levels with increased levels in pregnancies with a female fetus. These findings unravel important immunological dynamics of pregnancy, demonstrate how both maternal and fetal factors influence maternal systemic cytokines, and serve as a comprehensive reference for cytokine profiles in normal pregnancies.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Cytokine Patterns in Maternal Serum From First Trimester to Term and Beyond

et al. 2021

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“…In our study, we also observed a trend towards longer telomeres in placentas from women carrying a female. Moreover, we observed higher placental new-born weight ratio and fibroblast growth factor 2 in female’s placentas, which could indicate lower placenta ageing and a greater placental functional volume, with greater villous, angiogenesis and overall development, 37 , 38 as reported for placentas exposed to maternal exercise. 39 , 40 In agreement with our findings, Pac-Kożuchowska et al 8 also described greater placental-foetal weight ratio in females.…”

Section: Discussionsupporting

confidence: 61%

Differences in maternal and neonatal cardiometabolic markers and placenta status by foetal sex. The GESTAFIT project

Aparicio

García

Flor‐Alemany

et al. 2022

Womens Health (Lond Engl)

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Aims: To explore the differences in some maternal-neonatal metabolic markers and placenta status by foetal sex. Methods: One hundred thirty-nine Caucasian pregnant women from the GESTAFIT project and their new-borns were included in the present cross-sectional study. Serum cardiometabolic markers (i.e. lipid and glycaemic profile and uric acid) were analysed at late pregnancy and at birth. In placenta, telomeres length, proportion of deleted mitochondrial-DNA and mitochondrial-DNA density, some minerals and interleukin 8, epidermal growth factor, fibroblast growth factor-2 and vascular endothelial growth factor were measured. The study was run between November 2015 and April 2018. Results: Mothers carrying a male showed higher serum triglycerides than mothers carrying a female at late pregnancy ( p < .05). Serum total and low-density lipoprotein cholesterol were greater in males’ umbilical cord blood artery compared to females’ new-borns (both, p < .05). Mothers of males and male new-borns presented higher uric acid than mothers of females and female new-borns at birth ( p < .05). Female’s placentas presented greater placental-newborn weight ratio, manganese content and fibroblast growth factor-2 (all, p ⩽ .05), and evidence of statistical significance in telomeres length, which were 17% longer ( p = .076). Conclusion: Our findings show weak differences in some cardiometabolic and placental status markers by foetal sex. Notwithstanding, we observed a slightly more proatherogenic profile in both, mothers carrying males’ foetuses and male new-borns. We also found lower serum uric acid and better placenta status in mothers carrying a female. These findings indicate that foetal sex might need to be considered for a more personalized follow-up of pregnancies.

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“…Hereupon, considering the importance of cytokine networks in distinct Th subsets and as a result, shaping the response type (Ehsani et al, 2019;Kagina et al, 2015;Kaiko, Horvat, Beagley, & Hansbro, 2008;Mobini et al, 2015), the intracellular cytokine staining (ICS) by flowcytometry technique was used to determine the Th cytokine expression after treatment with FLLL32.…”

Section: Introductionmentioning

confidence: 99%

STAT3 inhibition reduced PD‐L1 expression and enhanced antitumor immune responses

Jahangiri

Dadmanesh

Ghorban

2020

Journal Cellular Physiology

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Colon cancer is one the most common diagnosed cancers in America and Europe. Signal transducer and activator of transcription 3 (STAT3) in colon cancer is associated with proliferation of the tumor cells and suppression of immune responses. STAT3 activation upregulates the transcription of many suppressor genes, including programmed death‐ligand 1 (PD‐L1). This study was aimed to investigate the effect of STAT3 inhibition in a colon cancer cell line, HCT‐15, and particularly in presence of samples obtained from the patients suffering from colon cancer. In this project, the expression of PD‐L1 and apoptosis‐related proteins were assessed following STAT3 inhibition, using FLLL32, in HCT‐15 cells. To evaluate the effects of STAT3 inhibition on immune response, lymphocytes from 20 men with Stage III colon cancer and 20 healthy donors were cocultured with HCT‐15 cells in presence or absence of STAT3 inhibitor. Then, T regulatory (T‐reg) cell evaluation and intracellular cytokine staining (ICS) were performed using flowcytometry to assess the T‐reg and T helper (Th) subset cytokines following STAT3 inhibition. STAT3 inhibition suppressed PD‐L1 expression and induced apoptosis in HCT‐15 cells. The population of T‐reg cells in patients with colon cancer significantly decreased after treatment with STAT3 inhibitor. ICS revealed that STAT3 inhibition promotes Th1 protective immune responses. These findings suggest that STAT3 inhibition through either induction of apoptosis in the colon cancer cells and/or activation of efficient immune responses can lead to overcome cancer‐induced immune tolerance.

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Role of maternal interleukin-8 (IL-8) in normal-term birth in the human

Cited by 14 publications

References 26 publications

Cytokine Patterns in Maternal Serum From First Trimester to Term and Beyond

Cytokine Patterns in Maternal Serum From First Trimester to Term and Beyond

Differences in maternal and neonatal cardiometabolic markers and placenta status by foetal sex. The GESTAFIT project

STAT3 inhibition reduced PD‐L1 expression and enhanced antitumor immune responses

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