Role of Mast Cells in Leprosy- A Study of 62 Cases

Jindal, Shivani; Manjari, Mridu; Girdhar, Monika

doi:10.14260/jemds/2017/1157

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…The data about MCs in leprosy, a chronic dermato-neurological granulomatous disease caused by Mycobacterium leprae , are controversial. Most of the studies indicate an increased number of MCs in skin biopsies of lepromatous lesions, in comparison with other leprosy forms ( 309 – 311 ), except for one study in which a higher dermal MC number was found around granulomas in skin biopsies from patients with tuberculoid or mild-borderline leprosy in comparison to lepromatous leprosy biopsies ( 312 ). A more recent study showed that there is a greater amount of degranulated versus intact MCs and a predominance of tryptase positive versus chymase positive MCs in the skin of leprosy patients, independently of leprosy form and reactional episodes ( 313 ).…”

Section: Detrimental Roles Of Mast Cells During Antimicrobial Responsementioning

confidence: 99%

Responses of Mast Cells to Pathogens: Beneficial and Detrimental Roles

et al. 2021

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Mast cells (MCs) are strategically located in tissues close to the external environment, being one of the first immune cells to interact with invading pathogens. They are long living effector cells equipped with different receptors that allow microbial recognition. Once activated, MCs release numerous biologically active mediators in the site of pathogen contact, which induce vascular endothelium modification, inflammation development and extracellular matrix remodeling. Efficient and direct antimicrobial mechanisms of MCs involve phagocytosis with oxidative and non-oxidative microbial destruction, extracellular trap formation, and the release of antimicrobial substances. MCs also contribute to host defense through the attraction and activation of phagocytic and inflammatory cells, shaping the innate and adaptive immune responses. However, as part of their response to pathogens and under an impaired, sustained, or systemic activation, MCs may contribute to tissue damage. This review will focus on the current knowledge about direct and indirect contribution of MCs to pathogen clearance. Antimicrobial mechanisms of MCs are addressed with special attention to signaling pathways involved and molecular weapons implicated. The role of MCs in a dysregulated host response that can increase morbidity and mortality is also reviewed and discussed, highlighting the complexity of MCs biology in the context of host-pathogen interactions.

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Section: Detrimental Roles Of Mast Cells During Antimicrobial Responsementioning

confidence: 99%

Responses of Mast Cells to Pathogens: Beneficial and Detrimental Roles

et al. 2021

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The effect of microgravity on mast cells as a multifunctional element of the immune system

Zhukov,

Alexeeva,

Sokolov

et al. 2024

Žurnal anatomii i gistopatologii

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The presented literature review is devoted to the problem of the influence of one of the space flight factors – microgravity on various elements of the immune system, in particular, mast cells (MCs). MCs are one of the parts of innate immunity. They are located in tissues almost everywhere, mainly in close proximity to blood vessels and nerves. Their numbers predominate in organs and tissues located on the border with the external environment. MCs are among the first to interact with invading pathogens. Activation of MCs leads to the release of a wide range of biologically active substances, such as heparin, histamine, chymase, tryptase, leukotrienes LTB4, LTD4, PDG2 and PAF, cytokines IL-10, IL-8, IL-5, IL-3, IL-1 , GM-CSF, TGF-β, VEGF and tumor necrosis factor TNF-α. MCs contribute to the development of allergies, cardiovascular and oncological pathologies, diseases of the respiratory system, and gastrointestinal tract. Numerous factors of spaceflight, such as microgravity, have a negative impact on the immune system. This effect affects the entire development process of immune cells (macrophages, monocytes, neutrophils, T and B lymphocytes, dendritic cells and NK cells), including their proliferation, differentiation, activation, and metabolism. Data is provided that the effect of microgravity on MCs manifests in increased apoptosis, decreased proliferation, as well as disruption of degranulation and secretion of cytokines. Morphofunctional changes in immune cells, including MCs, under microgravity conditions correlate with changes that occur in other mammalian cells and include the induction of apoptosis, changes in the cytoskeleton, disturbances in signaling pathways, cell differentiation, growth, proliferation, migration and adhesion.

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Role of Mast Cells in Leprosy- A Study of 62 Cases

Abstract: BACKGROUNDMast cells have received little attention in leprosy, but evidence linking them with delayed-type hypersensitivity reactions raises the possibility that they may be of some importance in leprosy.

Cited by 2 publications

References 7 publications

Responses of Mast Cells to Pathogens: Beneficial and Detrimental Roles

Responses of Mast Cells to Pathogens: Beneficial and Detrimental Roles

The effect of microgravity on mast cells as a multifunctional element of the immune system

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