2001
DOI: 10.1136/gut.48.5.630
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Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat

Abstract: Background and aims-Stress may be an important factor in exacerbating inflammatory bowel disease but the underlying mechanism is unclear. Defective epithelial barrier function may allow uptake of luminal antigens that stimulate an immune/inflammatory response. Here, we examined the eVect of chronic stress on colonic permeability and the participation of mast cells in this response. Methods-Mast cell deficient Ws/Ws rats and +/+ littermate controls were submitted to water avoidance stress or sham stress (one ho… Show more

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Cited by 266 publications
(258 citation statements)
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References 45 publications
(45 reference statements)
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“…In two recent studies (29,33), our laboratory found that rats exposed to chronic stress develop a prolonged barrier defect to macromolecules and epithelial mitochondrial damage (29). Longer exposure to stress induces bacterial internalization into the epithelium and inflammatory cell infiltration in the lamina propria, suggesting that stress can be important in the initiation of intestinal inflammation (33).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In two recent studies (29,33), our laboratory found that rats exposed to chronic stress develop a prolonged barrier defect to macromolecules and epithelial mitochondrial damage (29). Longer exposure to stress induces bacterial internalization into the epithelium and inflammatory cell infiltration in the lamina propria, suggesting that stress can be important in the initiation of intestinal inflammation (33).…”
Section: Discussionmentioning
confidence: 99%
“…Quantitative analysis of HRP uptake in intracellular endosomes and paracellular HRP transport were performed on coded high-magnification photomicrographs, 12 per rat (3 rats/group). The total area of HRP-containing endosomes within colonocytes was determined in an area of 300 m 2 in the apical region of the cells, by using a computerized image analysis system (Kontron Mop Videoplan, Kontron, Eching, Germany) (28,29).…”
Section: Epithelial Uptake Of Hrpmentioning
confidence: 99%
“…In the field of gastrointestinal research, stress induces irritable bowel syndrome, gastric ulcers, or gastric hemorrhages (Bennett et al, 1998). It has been established that physical and psychological stressors can induce marked alterations in water and electrolyte transport across the epithelium in the small intestines of rats (Santos et al, 2001;Bonaz and Tache, 1994). In those experiments, WAS, as psychological stress, altered the barrier and transport properties of the small intestine.…”
Section: Discussionmentioning
confidence: 99%
“…Santos et al (2000) showed that water avoidance stress (WAS) was a good psychological stress model. They demonstrated that WAS caused an epithelial barrier defect and epithelial mitochondrial damage of the colon, in parallel with mucosal mast cell hyperplasia and activation (Santos et al, 2001).…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, mast cells are involved in the regulation of intestinal permeability and the integrity of the epithelial barrier. [105][106][107] Studies focused on permeability assessment using urinary recovery of orally administered sugars or radioisotopes (Table 3) reported increased permeability in the small intestine, 22,108,109 with the exception of one study performed in children. 60 Several studies also highlighted an increased colonic permeability 60,71,[109][110][111] ; however, this result could not be consistently replicated by other groups.…”
Section: Intestinal Permeability In Ibs Patientsmentioning
confidence: 99%