Role of Mas receptor antagonist (A779) in renal hemodynamics in condition of blocked angiotensin II receptors in rats

Mansoori, Azam; Oryan, Shahrbanoo; Nematbakhsh, Mehdi

doi:10.1556/036.103.2016.1.2

Cited by 4 publications

(6 citation statements)

References 42 publications

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“…In male and female Wistar rats, simultaneous AT1R, AT2R, and MasR blocking, compared with only AT1R, AT2R blocking, Ang 1-7 infusion increased RBF response in males but not in female animals. So this finding indicated that renal vascular response to Ang 1-7 may not be exerted by MasR alone in males [ 91 , 92 ]. Some actions of Ang 1-7 could inhibit by the co-blockade of AT1R and AT2R.…”

Section: Mas Receptormentioning

confidence: 99%

“…AT1R, AT2R, and MasR blockade, then the pressure natriuresis and diuresis, RBF, and RVR response were studied. Data analysis shows that RBF, RVR, and the serum level of renin in both genders did not change whether MasR was blocked or not [93]. However, when the level of RPP was 100 mmHg, in the presence of MasR, urine flow rate (UF) and sodium excretion (UNaV) increased significantly in male but not female rats [93].…”

Section: Mas Receptormentioning

confidence: 99%

“…Data analysis shows that RBF, RVR, and the serum level of renin in both genders did not change whether MasR was blocked or not [93]. However, when the level of RPP was 100 mmHg, in the presence of MasR, urine flow rate (UF) and sodium excretion (UNaV) increased significantly in male but not female rats [93]. As a result, co-blocking AT1R and AT2R, MasR effect in pressure diuresis and natriuresis sex-dependent, and in the presence of MasR, this response increased in male but not female rats [93].…”

Section: Mas Receptormentioning

confidence: 99%

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Sex Difference in MasR Expression and Functions in the Renal System

Choopani

Nematbakhsh

2022

J Renin Angiotensin Aldosterone Syst

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Renin-angiotensin system (RAS), as a critical system for controlling body fluid and hemostasis, contains peptides and receptors, including angiotensin 1-7 (Ang 1-7) and Mas receptor (MasR). Ang 1-7 implements its function via MasR. Ang II is another peptide in RAS that performs its actions via two Ang II type 1 and 2 receptors (AT1R and AT2R). The functions of AT2R and MasR are very similar, and both have a vasodilation effect, while AT1R has a vasoconstriction role. MasR affects many mechanisms in the brain, heart, blood vessels, kidney, lung, endocrine, reproductive, skeletal muscle, and liver and probably acts like a paracrine hormone in these organs. The effect of Ang 1-7 in the kidney is complex according to the hydroelectrolyte status, the renal sympathetic nervous system, and the activity level of the RAS. The MasR expression and function seem more complex than Ang II receptors and have interacted with Ang II receptors and many other factors, including sex hormones. Also, pathological conditions including hypertension, diabetes, and ischemia-reperfusion could change MasR expression and function. In this review, we consider the role of sex differences in MasR expression and functions in the renal system under physiological and pathological conditions.

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Section: Mas Receptormentioning

confidence: 99%

Section: Mas Receptormentioning

confidence: 99%

Section: Mas Receptormentioning

confidence: 99%

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Sex Difference in MasR Expression and Functions in the Renal System

Choopani

Nematbakhsh

2022

J Renin Angiotensin Aldosterone Syst

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“…Ang1-7 is one of the vasodilatory arm of RAS that not able to cross the blood-brain barrier, and it seems that the role peripheral Ang1-7 on the BRS index and renal function needs to be studied. In addition, the Ang1-7 receptor is reported to be acted gender related (4). Therefore we hypothesized that Ang1-7 infusion alters the BRS index and renal function, and this hypothesis was tested in bilateral renal denervation (RDN) and non-RDN male and female animal's model.…”

Section: Introductionmentioning

confidence: 99%

Angiotensin 1-7 administration alters baroreflex sensitivity and renal function in sympathectomized rats

Azadbakht¹,

Nematbakhsh²

2017

J Nephropathol

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Background: Renin-angiotensin system (RAS) plays an important role in cardiovascular and kidney functions to regulate the systematic blood pressure. The baroreflex sensitivity (BRS) index is a quantitative index that was considered as a prognostic indicator for cardiovascular system risk which is known as heart rate change to blood pressure change ratio ( HR MAP ∆ ∆). Sympathetic nerve is an arm of the BRS which may be influenced by RAS vasodilatory arm function. Objectives: To determine the role of angiotensin 1-7 (Ang1-7) accompanied by bilateral renal denervation (RDN) on BRS and renal function. Methods: Male and female anesthetized Wistar rats were subjected to RDN and treated with Ang1-7 (300 and 1000 ng.kg -1 .min -1 ). Mean arterial pressure (MAP) and heart rate (HR) responses to phenylephrine (PE) infusion were measured to determine BRS index. As kidney function markers, the creatinine clearance (CrCl) and urine flow (UF) were also determined. Results: The results showed that BRS increased significantly in RDN male rats treated with Ang1-7 compared to vehicle (P < 0.05). BRS attenuates significantly in RDN male rats treated with vehicle or Ang1-7 when compared with non-RDN (control). In female rats, the BRS decreased significantly in Ang1-7 treated group (P < 0.05). Also, the BRS was significantly different between non-RDN and RDN female rats treated with Ang1-7 (P < 0.05). The ClCr in female and UF in both genders increased by Ang1-7 infusion in RDN and non-RDN rats. The alteration of serum nitrite level by Ang1-7 in non-RDN and RDN groups was gender related. Conclusions: The Ang1-7 infusion could alter the BRS index in RDN rat's gender dependently. The ClCr response to Ang1-7 infusion in male rats was dose related. ABSTRACT Implication for health policy/practice/research/medical education:To find the role of renal sympathectomy and Ang1-7 infusion in renal function and BRS index. Please cite this paper as: Azadbakht MK, Nematbakhsh M. Angiotensin 1-7 administration alters baroreflex sensitivity and renal function in sympathectomized rats.

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“…There also is an interaction between the components of RAS. So, MasR not only acts as a specific receptor for Ang 1–7 but also interacts with AT 1 R and AT 2 R and alters the renal vascular responses to Ang II [ 24 , 25 ]. In addition, IR and hypertension are risk factors for AKI, the delayed function of transplanted kidney, transplant rejection, and patient survival [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Mas Receptor Blockade Promotes Renal Vascular Response to Ang II after Partial Kidney Ischemia/Reperfusion in a Two-Kidney-One-Clip Hypertensive Rats Model

Karimi

Nematbakhsh

2021

International Journal of Nephrology

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Background. Partial kidney ischemia-reperfusion (IR) injury is the principal cause of acute kidney injury. The renin-angiotensin system (RAS) and hypertension also may be influenced by renal IR injury. In two models of partial renal IR with and without ischemia preconditioning (IPC) and using Mas receptor (MasR) blockade, A779 or its vehicle, the renal vascular responses to angiotensin II (Ang II) administration in two-kidney-one-clip (2K1C) hypertensive rats were determined. Methods. Thirty-seven 2K1C male Wistar rats with systolic blood pressure ≥150 mmHg were randomly divided into three groups; sham, IR, and IPC + IR. The animals in the sham group underwent surgical procedures except partial IR. The rats in the IR group underwent 45 min partial kidney ischemia, and the animals in the IPC + IR group underwent two 5 min cycles of partial kidney ischemia followed by 10 min reperfusion and partial kidney ischemia for 45 min. The renal vascular responses to graded Ang II (30, 100, 300, and 1000 ng kg−1.min−1) infusion using A779 or its vehicle were measured at constant renal perfusion pressure. Results. Four weeks after 2K1C implementation, the intravenous infusion of graded Ang II resulted in dose-related increases in mean arterial pressure (MAP) ( P dose < 0.0001) that was not different significantly between the groups. No significant differences were detected between the groups in renal blood flow (RBF) or renal vascular resistance (RVR) responses to Ang II infusion when MasR was not blocked. However, by MasR blockade, these responses were increased in IR and IPC + IR groups that were significantly different from the sham group ( P < 0.05). For example, infusion of Ang II at dose 1000 ng kg−1.min−1 resulted in decreased RBF percentage change (RBF%) from the baseline to 17.5 ± 1.9%, 39.7 ± 3.8%, and 31.0 ± 3.4% in sham, IR, and IPC + IR, respectively. Conclusion. These data revealed the important role of MasR after partial kidney IR in the responses of RBF and RVR to Ang II administration in 2K1C hypertensive rats.

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Role of Mas receptor antagonist (A779) in renal hemodynamics in condition of blocked angiotensin II receptors in rats

Cited by 4 publications

References 42 publications

Sex Difference in MasR Expression and Functions in the Renal System

Sex Difference in MasR Expression and Functions in the Renal System

Angiotensin 1-7 administration alters baroreflex sensitivity and renal function in sympathectomized rats

Mas Receptor Blockade Promotes Renal Vascular Response to Ang II after Partial Kidney Ischemia/Reperfusion in a Two-Kidney-One-Clip Hypertensive Rats Model

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