Role of malaria induced oxidative stress on anaemia in pregnancy

Akanbi, OM; Odaibo, A. B.; Olatoregun, R; Ademowo, AB

doi:10.1016/s1995-7645(10)60011-9

Cited by 7 publications

(7 citation statements)

References 10 publications

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“…In relation to trimesters, the pregnant women in their first trimester were more prone to malaria infection. This result is in agreement with the works of 13 in Western Kenya and 20 in Nigeria, but disagrees with the report of 23 where it was found out that pregnant women in their second trimester were more prone (had the highest prevalence) to malaria infection.…”

Section: Discussionsupporting

confidence: 67%

“…Fetal and prenatal mortality, which sometimes lead to premature and false labour, occur in malarious mothers, although the incidence of preterm delivery is significantly increased only in non-immune mothers or those with low level of acquired immunity. Different studies have shown that malaria infection is more prevalent in primigravidae than in multigravidae 13 .…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Malaria Parasites among Pregnant Women and Children under Five years in Ekiti State, Southwest Nigeria.

Simon-Oke

2019

J. Biomed. Transl. Res.

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Background: Malaria is a deadly disease causing serious public health issues among pregnant women and children worldwide especially in tropical and subtropical Africa. This study was carried out to determine the prevalence of malaria parasites among pregnant women and children under five years in Ekiti State, Nigeria.Methodology: A total of 380 blood samples were collected from the pregnant women and children under five years respectively. Malaria parasites were examined microscopically on thick and thin blood smear stained with Giemsa stain while personal data were collected through questionnaire and confirmed from file records. Red cell phenotyping was carried out manually with standard tube technique for blood group. Haemoglobin electrophoresis was carried out using the cellulose acetate alkaline haemoglobin electrophoresis technique, which allowed for the separation of haemoglobin A, F, S, and C into distinct bands.Results: The results showed that of 380 pregnant women sampled, 153 (40.2%) were positive for malaria parasites and 63 (63%) were positive of the 100 children sampled. The highest prevalence of malaria parasites 18 (51.4%) and 25 (71.4%) were observed in ages 36-39 and <1 years for pregnant women and children respectively. Multigravidae was 1.19 times (95% Cl: 0.77, 1.84) more vulnerable to malaria compare to primigravidae. Women in the first trimester were more infected with malaria parasites 40 (75.4%) than those in second trimester 46 (23.3%) and third trimester 67 (51.9%). Among children under five years of age, females 38 (66.7%) had the highest prevalence compared to males 25 (58.1%). However, there was no significant difference. Statistical analysis showed a significant difference in genotype types (P<0.05).Conclusion: This study revealed that malaria infection is still endemic in the study area, hence, there is urgent need to deploy management strategy to the study area.

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Section: Discussionsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Prevalence of Malaria Parasites among Pregnant Women and Children under Five years in Ekiti State, Southwest Nigeria.

Simon-Oke

2019

J. Biomed. Transl. Res.

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“…It is well known that UA can induce inflammatory responses and as such, we found a direct influence between higher UA levels and CRP levels. [ 7 18 33 34 ] In this study, upon comparison with MM groups, women with SM had significantly increased serum UA levels, especially during Pf infections. This suggests that there exists a possible strong inflammatory response by UA which might play an important role in augmenting the malarial severity from MM to its severe forms, leading to pregnancy complications.…”

Section: Discussionmentioning

confidence: 62%

Impact of oxidative stress in response to malarial infection during pregnancy: Complications, histological changes, and pregnancy outcomes

et al. 2022

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Background and Objectives: Pregnancy malaria is a major underestimated global public health problem. To understand the involvement of oxidative stress (OS) in the pathophysiology of placental malaria, OS biomarkers, malondialdehyde (MDA), uric acid (UA), and superoxide dismutase (SOD) levels were analyzed and correlated to placental histopathological changes and pregnancy outcomes. Methods: A hospital-based study was conducted in Mangaluru, Karnataka, India, to analyze the changes in hematological parameters and the serum OS biomarker levels. Histological analysis of placenta, associated complications, and pregnancy outcomes were compared using Kruskal–Wallis test, and pairwise comparison between two groups was made by Mann–Whitney U-test. Correlations were calculated by Pearson's and Spearman's rank correlations. Results: Among 105 pregnant women, 34 were healthy controls and the infected group comprised of Plasmodium Vivax (Pv) ( n = 48), Plasmodium falciparum (Pf) ( n = 13), and mixed ( n = 10) malaria infections. Of 71 infected cases, 67.6% had mild malaria, whereas 32.4% had severe malaria. The white blood cell and C-reactive protein levels were found to increase, whereas hemoglobin, red blood cell, and platelet levels decreased during both types of malarial infections. The MDA and UA values increased and SOD levels decreased particularly during severe Pf infections. Histological changes such as syncytial knots, syncytial ruptures, and fibrinoid necrosis were observed particularly during Pf infections and leukocyte infiltration was observed in Pv malaria Conclusion: Evaluation of MDA, UA, and SOD levels can serve as an indicator of OS during pregnancy malaria. The OS during pregnancy may lead to complications such as severe anemia, pulmonary edema, intra uterine growth retardation, premature delivery, and low birth weight, not only during Pf but also in Pv malaria. It is important to create awareness among rural and immigrant population residing in Mangaluru and its surroundings about required preventive measures and free government-supported antenatal care services.

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“…In 2010, the annual incidence rate of malaria in the Solomon Islands was 77 cases per 1,000 people (MHMS, 2012). Compared with nonpregnant women with malaria, pregnant women who contact malaria are more likely to experience higher parasite density, severe anemia, lower hemoglobin levels, and death (Akanbi, Odaibo, Olatoregun, & Ademowo, 2010). Maternal malaria also increases the risk of miscarriage, stillbirth, premature birth, and low birth weight (Launiala & Kulmala, 2006).…”

Section: Maternal Health In the Solomon Islandsmentioning

confidence: 99%

Health Care Providers’ Perceptions of Maternal Health Concerns in the Solomon Islands

et al. 2014

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The results of this study provide a useful first step toward identifying specific maternal health risks among women in the Solomon Islands. The findings may assist the health sector and midwives/antenatal educators to better understand the health risks and reduce the disease burden among pregnant women in South Pacific countries. The results may also contribute to the development of policies to improve maternal health and to accelerate progress toward the fifth target goal of UNICEF's Millennium Development Goals.

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Role of malaria induced oxidative stress on anaemia in pregnancy

Cited by 7 publications

References 10 publications

Prevalence of Malaria Parasites among Pregnant Women and Children under Five years in Ekiti State, Southwest Nigeria.

Prevalence of Malaria Parasites among Pregnant Women and Children under Five years in Ekiti State, Southwest Nigeria.

Impact of oxidative stress in response to malarial infection during pregnancy: Complications, histological changes, and pregnancy outcomes

Health Care Providers’ Perceptions of Maternal Health Concerns in the Solomon Islands

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