Role of magnetic resonance diffusion-weighted imaging in evaluating response after chemoembolization of hepatocellular carcinoma

Zheng, Yuxin; Ye, Xiaodan; Dong, Sheng; Xu, Lichao; Xue-yuan, XU; Liu, Shi-yuan; Xiang-sheng, Xiao

doi:10.1016/j.ejrad.2009.05.040

Cited by 70 publications

(45 citation statements)

References 24 publications

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“…A significantly higher pretreatment mean ADC was seen in non-responding lesions (1.726±0.323 x 10 -3 mm 2 /s) than in responding lesions (1.294±0.185 x 10 -3 mm 2 /s) in the study by Yuan et al (33), while no significant difference was evident in our study. Although the reason for this controversial result is unclear, all lesions showed early enhancement on dynamic contrast-enhanced CT in this study, while the presence of early enhancement is not clearly described in the study by Yuan et al (33). The response of HCC to TACE generally depends on the presence of early enhancement on contrast-enhanced CT, which may indicate a lower ADC value in the lesion due to less necrosis (33).…”

Section: Discussioncontrasting

confidence: 53%

“…Although the reason for this controversial result is unclear, all lesions showed early enhancement on dynamic contrast-enhanced CT in this study, while the presence of early enhancement is not clearly described in the study by Yuan et al (33). The response of HCC to TACE generally depends on the presence of early enhancement on contrast-enhanced CT, which may indicate a lower ADC value in the lesion due to less necrosis (33). HCC without enhancement on contrastenhanced CT in the study by Yuan et al may thus have contributed to the discrepancy between the two studies.…”

Section: Discussioncontrasting

confidence: 37%

“…Kamel et al (9) and Chen et al (8) reported that the ADC value in human HCC increases after TACE. ADC was significantly higher in lesions that responded to TACE than in non-responding lesions (33). However, the percent change in ADC from baseline showed a similar area under the curve in ROC analysis for differentiation of relapsed and non-relapsed lesions with iodizedoil CT in the current study.…”

Section: Discussionmentioning

confidence: 68%

“…The difference in ADC values between responding and non-responding lesions before TACE produced controversial results in a study carried out by Yuan et al (33) and this study. A significantly higher pretreatment mean ADC was seen in non-responding lesions (1.726±0.323 x 10 -3 mm 2 /s) than in responding lesions (1.294±0.185 x 10 -3 mm 2 /s) in the study by Yuan et al (33), while no significant difference was evident in our study.…”

Section: Discussionmentioning

confidence: 99%

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Role of diffusion-weighted imaging in evaluating therapeutic efficacy after transcatheter arterial chemoembolization for hepatocellular carcinoma

Kubota

Yamanishi²,

Itoh³

et al. 2010

Oncol Rep

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Abstract. The decision to repeat transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) is based on correct evaluation of response to therapy. The purpose of this study was to investigate whether apparent diffusion coefficient (ADC), a quantitative parameter of diffusionweighted imaging (DWI), can predict early HCC recurrence after TACE. Results obtained using this method were compared with those using iodized-oil computed tomography (CT). DWI was performed on 25 patients with 36 HCCs before and 5-7 days after TACE to calculate the ADC of HCC. Patients were also evaluated with iodized-oil CT immediately after TACE. Contrast-enhanced CT was performed 3 months after TACE to confirm early relapse of HCC lesion. After TACE, the percent change in ADC (%ADC) from before to after therapy was significantly increased in non-relapsed lesions (85.2±12.4%) compared to relapsed lesions (8.0±56.7%, p=0.0004). However, no difference in area under the curve was seen for receiver operating characteristic analysis to predict early relapse after TACE between %ADC from DWI (95% confidence interval, 0.743-1.026) and iodized-oil CT (95% confidence interval, 0.703-1.016). ADC from DWI can evaluate the efficacy of TACE for HCC as effectively as iodized-oil CT, and may help in deciding whether to repeat TACE.

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Section: Discussioncontrasting

confidence: 53%

Section: Discussioncontrasting

confidence: 37%

Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

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Role of diffusion-weighted imaging in evaluating therapeutic efficacy after transcatheter arterial chemoembolization for hepatocellular carcinoma

Kubota

Yamanishi²,

Itoh³

et al. 2010

Oncol Rep

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“…This technology has also proven useful in early assessment of tumour response post-therapy, including TACE of hepatocellular carcinoma [20,21] and metastatic hepatic nodules [22,23]. Not relying on change in tumour size to monitor response could pave the way to earlier changes in therapy, demonstrates a case of a liver metastatic nodule which we treated with TACE.…”

Section: Role Of Diagnostic Radiology In Interventional Oncologymentioning

confidence: 99%

Emerging Trends in Oncology: Greater Role for Radiology

Loong¹

2013

J Med Diagn Meth

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Interventional oncology is a rapidly emerging technologydriven subspecialty within radiology. Several notable therapeutic developments over the last few years offer patients hope in the fight against cancer, especially when conventional therapy has failed or is deemed unsuitable. Within the field of diagnostic radiology, functional imaging has also emerged as an essential tool in the fight against cancer, given its ability to predict tumour response earlier than anatomical imaging, as well as detect early recurrence.

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Whole‐body MRI including diffusion‐weighted imaging (DWI) for patients with recurring prostate cancer: Technical feasibility and assessment of lesion conspicuity in DWI

Eiber

Holzapfel

Ganter

et al. 2011

Magnetic Resonance Imaging

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Purpose: To evaluate the principal methodological aspects of whole-body magnetic resonance imaging (MRI) including diffusion-weighted imaging (DWI) with background suppression using a time-optimized protocol for restaging of prostate cancer patients in a technical feasibility study. Materials and Methods:Seventeen patients underwent MRI at 1.5T from the base of the skull to the proximal thigh using axial T1-weighted (T1w), T2w short-tau inversion recovery (STIR), and DWI (b-values: 50 and 500 s/ mm 2 ) and sagittal T1w and T2w STIR of the spine. Apparent diffusion coefficient (ADC) values of liver, spleen, kidney, muscle, and bone were measured. Image quality in DWI was assessed by using a scale from 0-9. Contrast-tonoise ratios (CNRs) of lymph node and bone metastases were determined in T1w, T2w STIR, and DWI. Bone metastases were further subclassified according to their Hounsfield units (HU) in computed tomography (CT).Results: Mean acquisition and mean room times were 66:20 and 75:21 minutes, respectively. ADC values of normal organs showed good concordance with reported data. Good to excellent image quality was observed for DWI (mean scores 7.41-8.00) with the exception of the neck (mean score 4.76). CNR of DWI (b-value 50 s/mm 2 ) for lymph node metastases was clearly superior compared to all other sequences. For bone metastases T1w performed significantly better for sclerotic lesions (HU > 600), DWI (bvalue 50 s/mm 2 ) for nonsclerotic lesion (HU < 300). Conclusion:In patients with recurrent prostate cancer a whole-body MR protocol including DWI is technically robust. Due to the high CNR of DWI compared to T1w and T2w STIR, detection of malignant lesions should be facilitated by DWI, except for sclerotic bone metastases.

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Role of magnetic resonance diffusion-weighted imaging in evaluating response after chemoembolization of hepatocellular carcinoma

Cited by 70 publications

References 24 publications

Role of diffusion-weighted imaging in evaluating therapeutic efficacy after transcatheter arterial chemoembolization for hepatocellular carcinoma

Role of diffusion-weighted imaging in evaluating therapeutic efficacy after transcatheter arterial chemoembolization for hepatocellular carcinoma

Emerging Trends in Oncology: Greater Role for Radiology

Whole‐body MRI including diffusion‐weighted imaging (DWI) for patients with recurring prostate cancer: Technical feasibility and assessment of lesion conspicuity in DWI

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