Role of magnesium in the pathogenesis of hypertension

Low [Mg 2+ ] e Enhances Arterial Spontaneous Tone via Phosphatidylinositol 3-Kinase in DOCA-Salt Hypertension

“…[7][8][9] Intracellular Mg 2ϩ concentration ([Mg 2ϩ ] i ) regulates contractile proteins; modulates transmembrane transport of calcium, sodium, and potassium; acts as a essential cofactor in activation of ATPases; and influences DNA and protein synthesis. 9 -11 Mg 2ϩ concentrations are inversely proportional to blood pressure, with hypomagnesemia associated with hypertension.…”

Dose-response relationship between dietary magnesium intake and cardiovascular mortality: A systematic review and dose-based meta-regression analysis of prospective studies

“…The inverse association between magnesium intake and CVD mortality may be partially explained by its effects on lowering blood pressure (BP), improving endothelial function, inhibiting inflammation and platelet aggregation [44,45]. Several mechanisms have been proposed for the potential cardiometabolic benefits of magnesium intake, including improvement of glucose and insulin homeostasis; antihypertensive, antiarrhythmic, anti-inflammatory, anticoagulant, or antiplatelet effects; improved lipid metabolism; reduced vascular contractility; and increased endothelium-dependent vasodilation [46].…”

Hypertension, Diabetes

“…Antioxidative flavonoids together with pharmacological actions of magnesium could be a candidate for such an effective combination. 5 …”

“…4 Animal models of magnesium deficiency have indicated an association between hypertension and an increased production of reactive oxygen species and an elevation of MAP kinase-dependent signaling. 5 Although evidence from human studies remains equivocal, supplementation with magnesium has been shown to significantly lower blood pressure in patients with essential hypertension. 5 Thus, the increase in magnesium intake associated with consumption of dark chocolate may have contributed to the beneficial outcomes found in our study.…”

“…5 Although evidence from human studies remains equivocal, supplementation with magnesium has been shown to significantly lower blood pressure in patients with essential hypertension. 5 Thus, the increase in magnesium intake associated with consumption of dark chocolate may have contributed to the beneficial outcomes found in our study. We agree with Meisel and suggest that further investigation into the potential additive or synergistic interaction between flavonoids and magnesium is warranted.…”