Role of magnesium and aluminum substitution on the structural properties and bioactivity of bioglasses synthesized from biogenic silica

Karakuzu-Ikizler, Burcu; Terzioğlu, Pınar; Elalmış, Yeliz Başaran; Tekerek, Bilge Sema; Yücel, Sevil

doi:10.1016/j.bioactmat.2019.12.007

Cited by 38 publications

(18 citation statements)

References 46 publications

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“…Bone-G Active ® and produced Al2O3 doped glasses and their compositions are given in Table 1. Al2O3 doped bioactive glasses were produced according to a previously reported method (13,14). Briefly, raw materials were first weighed, homogeneously mixed, and melted in a platinum crucible at 1400 °C, and then quenched into the water at room temperature.…”

Section: Production Of Bioactive Glass and Alumina Doped Bioactive Glmentioning

confidence: 99%

Effect of Al2O3 Doping on Antibacterial Activity of 45S5 Bioactive Glass

Elalmış

2021

Journal of the Turkish Chemical Society Section A: Chemistry

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45S5 bioactive glasses (BGs) are special class of glasses that form chemical bonds with surrounding bone tissue, which is due to the dissolution behavior of these glass materials. Furthermore, BG shows an antibacterial effect since the dissolution of BG results with high aqueous pH that affect bacterial viability. In this study, the antibacterial activity of Al2O3 doped bioactive glasses (AGs) was evaluated. AGs were produced via the melt quenching method. Functional groups of glasses were evaluated with Fourier Transform Infrared (FTIR) analysis, and glassy structure was evaluated by X-ray diffraction (XRD). Specific surface area, particle size information, and density of milled BG and AGs were obtained using surface area and porosity instrument, laser scattering particle size distribution analyzer and He pycnometer, respectively. Antibacterial activity of bioactive glasses was investigated on Staphylococcus aureus and Escherichia coli via Standard Colony Count Method at 50 mg/mL concentration and different time points, pH change of the media in the presence of BG and AGs at 50 mg/mL concentration was also measured at identical time points. XRD analysis revealed amorphous structure of BG and AGs. Similar specific surface area, particle size and density values were obtained for BG and produced AGs. Antibacterial test results showed that Al2O3 doped 45S5 bioactive glasses had decreased antibacterial activity compared to 45S5 bioactive glass for both bacteria studied.

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Section: Production Of Bioactive Glass and Alumina Doped Bioactive Glmentioning

confidence: 99%

Effect of Al2O3 Doping on Antibacterial Activity of 45S5 Bioactive Glass

Elalmış

2021

Journal of the Turkish Chemical Society Section A: Chemistry

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“…Bone tissue engineering (BTE) emerged as a promising solution to overcome the limitations of auto- and allografts. BTE combines concepts from bone biology and engineering techniques to design scaffolds enriched with stem cells to repair large bony defects (Bishop et al, 2017 ; Coalson et al, 2019 ; Qasim et al, 2019 ; Karakuzu-Ikizler et al, 2020 ; Wang et al, 2020a ). However, bone tissue engineering practices have yet to be realized in clinical practice due to numerous limitations or lack of efficacy.…”

Section: Introductionmentioning

confidence: 99%

Stem Cell-Friendly Scaffold Biomaterials: Applications for Bone Tissue Engineering and Regenerative Medicine

Zhang

Zhao

et al. 2020

Front. Bioeng. Biotechnol.

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Bone is a dynamic organ with high regenerative potential and provides essential biological functions in the body, such as providing body mobility and protection of internal organs, regulating hematopoietic cell homeostasis, and serving as important mineral reservoir. Bone defects, which can be caused by trauma, cancer and bone disorders, pose formidable public health burdens. Even though autologous bone grafts, allografts, or xenografts have been used clinically, repairing large bone defects remains as a significant clinical challenge. Bone tissue engineering (BTE) emerged as a promising solution to overcome the limitations of autografts and allografts. Ideal bone tissue engineering is to induce bone regeneration through the synergistic integration of biomaterial scaffolds, bone progenitor cells, and bone-forming factors. Successful stem cell-based BTE requires a combination of abundant mesenchymal progenitors with osteogenic potential, suitable biofactors to drive osteogenic differentiation, and cell-friendly scaffold biomaterials. Thus, the crux of BTE lies within the use of cell-friendly biomaterials as scaffolds to overcome extensive bone defects. In this review, we focus on the biocompatibility and cell-friendly features of commonly used scaffold materials, including inorganic compound-based ceramics, natural polymers, synthetic polymers, decellularized extracellular matrix, and in many cases, composite scaffolds using the above existing biomaterials. It is conceivable that combinations of bioactive materials, progenitor cells, growth factors, functionalization techniques, and biomimetic scaffold designs, along with 3D bioprinting technology, will unleash a new era of complex BTE scaffolds tailored to patient-specific applications.

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“…It plays a significant role in stimulating osteoblastic cells, and it reduces bone resorption 14 . In this regard, magnesium-contained bioactive glasses are widely studied 3,14,15 . It was found that the incorporation of MgO in the bioactive glass accelerates the early stages of the precipitation of HAC layer 15 .…”

Section: Introductionmentioning

confidence: 99%

“…In this regard, magnesium-contained bioactive glasses are widely studied 3,14,15 . It was found that the incorporation of MgO in the bioactive glass accelerates the early stages of the precipitation of HAC layer 15 . However, some studies have reported that MgO slows down the precipitation rate of HAC 16,17 .…”

Section: Introductionmentioning

confidence: 99%

Physicochemical and in vitro bioactivity studies of bioactive glasses in the SiO2-CaO-MgO-P2O5, SiO2-Na2O-CaO-P2O5 and SiO2-Na2O-CaO-MgO-P2O5 systems

et al. 2020

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Glasses in the quaternary and quinary system SiO2-CaO-MgO-P2O5 (SCMP), SiO2-Na2O-CaO-P2O5 (SNCP) and SiO2-Na2O-CaO-MgO-P2O5 (SNCMP), have been prepared by using the sol-gel technique. Investigations of structural and bioactive properties of these glasses have been undertaken by using X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray Spectroscopy (EDS). The in vitro bioactivity was assessed by determining the changes in surface morphology and composition after soaking in simulated body fluid (SBF) for up to 30 days at 37°C. X-ray diffraction patterns indicated the formation of hydroxycarbonated apatite layer (HCA) after only one hour for SNCMP glass and after four days for SCMP and SNCP glasses. Furthermore, observed bands of FTIR spectra confirmed the growth of HCA layer during in vitro test.Moreover, the dissolution rate has been investigated using energy-dispersive X-ray spectroscopy. The observed EDS patterns confirmed the growth of HCA layer on all samples surfaces during in vitro analysis. On the one hand, we report the existence of Na2Ca2Si3O9 (that couple good mechanical strength with satisfactory biodegradability) as a single crystalline phase in the SNCP glass when calcined at 600°C. On the other hand, we have noticed that the coexistence of magnesium and sodium both enhanced the dissolution rate and hindered the crystallization in the SNCMP glass at 600°C.

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Role of magnesium and aluminum substitution on the structural properties and bioactivity of bioglasses synthesized from biogenic silica

Cited by 38 publications

References 46 publications

Effect of Al2O3 Doping on Antibacterial Activity of 45S5 Bioactive Glass

Effect of Al2O3 Doping on Antibacterial Activity of 45S5 Bioactive Glass

Stem Cell-Friendly Scaffold Biomaterials: Applications for Bone Tissue Engineering and Regenerative Medicine

Physicochemical and in vitro bioactivity studies of bioactive glasses in the SiO2-CaO-MgO-P2O5, SiO2-Na2O-CaO-P2O5 and SiO2-Na2O-CaO-MgO-P2O5 systems

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