Role of MafB in macrophages

Hamada, Michito; Tsunakawa, Yuki; Jeon, Hyojung; Yadav, Manoj Kumar; Takahashi, Satoru

doi:10.1538/expanim.19-0076

Cited by 54 publications

(45 citation statements)

References 85 publications

(105 reference statements)

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“…In addition, it was observed that MAFB limits the ability of M-CSF to differentiate hematopoietic stem cells towards the myeloid program (70). MAFB can also impact the function of macrophages in several pathological models (73)(74)(75)(76). In the context of metabolic disease, animals harboring MAFB-deficient macrophages were shown to be more susceptible to obesity in a hyper caloric setting 75 Macrophages adapt to the tissue environment in which they reside, and are, therefore, different in every tissue (4,43,77).…”

Section: Discussionmentioning

confidence: 99%

c-MAF dependent perivascular macrophages regulate diet induced metabolic syndrome

Moura

Kitoko

Queiroz

et al. 2021

Preprint

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Macrophages are an essential part of tissue development and physiology. Perivascular macrophages have been described in tissues and appear to play a role in development and disease processes, although it remains unclear what are the key features of these cells. Here, we identify a subpopulation of perivascular macrophages in several organs, characterized by their dependence on the transcription factor c-MAF, displaying non-conventional macrophage markers including LYVE1, Folate receptor 2 and CD38. Conditional deletion of c-MAF in macrophage lineages caused ablation of perivascular macrophages in the brain and altered muscularis macrophages program in the intestine. In the white adipose tissue (WAT), c-MAF deficient perivascular macrophages displayed an altered gene expression profile, which was linked to an increased vascular branching into the tissue. Upon feeding on high fat diet (HFD), mice with c-MAF deficient macrophages showed improved metabolic parameters compared to wild-type mice, including less weight gain, greater glucose tolerance and reduced inflammatory cell profile in WAT. These results define c-MAF as a central regulator of perivascular macrophages cell identity and transcriptional program in vivo and reveal a novel role for this tissue resident macrophage population in the regulation of metabolic syndrome.

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Section: Discussionmentioning

confidence: 99%

c-MAF dependent perivascular macrophages regulate diet induced metabolic syndrome

Moura

Kitoko

Queiroz

et al. 2021

Preprint

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“…Nevertheless, AMs clearly proliferate in response to colony-stimulating factors GM-CSF and M-CSF ( Chen et al, 1988 ; Draijer et al, 2019 ), with mTORC1 ( Deng et al, 2017 ) and the transcription factors Bhlhe40 and Bhlhe41 ( Rauschmeier et al, 2019 ) being responsible for this process. MafB, another transcription factor that is necessary for maintenance of AM numbers ( Sato-Nishiwaki et al, 2013 ), is also expressed at very low levels in AMs ( Hamada et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

PGE₂accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking

et al. 2020

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Alveolar macrophages (AMs) are resident immune cells of the lung that are critical for host defense. AMs are capable of proliferative renewal, yet their numbers are known to decrease with aging and increase with cigarette smoking. The mechanism by which AM proliferation is physiologically restrained, and whether dysregulation of this brake contributes to altered AM numbers in pathologic circumstances, however, remains unknown. Mice of advanced age exhibited diminished basal AM numbers and contained elevated PGE2 levels in their bronchoalveolar lavage fluid (BALF) as compared with young mice. Exogenous PGE2 inhibited AM proliferation in an E prostanoid receptor 2 (EP2)-cyclic AMP-dependent manner. Furthermore, EP2 knockout (EP2 KO) mice exhibited elevated basal AM numbers, and their AMs resisted the ability of PGE2 and aged BALF to inhibit proliferation. In contrast, increased numbers of AMs in mice exposed to cigarette smoking were associated with reduced PGE2 levels in BALF and were further exaggerated in EP2 KO mice. Collectively, our findings demonstrate that PGE2 functions as a tunable brake on AM numbers under physiologic and pathophysiological conditions.

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“…Splenic macrophages play significant roles in blood filtration (Klei, Meinderts, Berg, & Bruggen, 2017). MafB is a basic leucine zipper transcription factor encoded by the Mafb gene and was found to be required for several processes including macrophage differentiation and islet beta cells development (Abdellatif et al, 2015; Abdellatif et al, 2016; Hamada, Tsunakawa, Jeon, Yadav, & Takahashi, 2020). MafB was also reported to be expressed by large proportion of splenic macrophages in mice (Lloyd, Phillips, Cooper, & Dunbar, 2008).…”

Section: Discussionmentioning

confidence: 99%

Structure of the Eurasian moorhen spleen: A comprehensive study using gross anatomy, light, and transmission electron microscopy

Abdellatif

2021

Microscopy Res & Technique

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The spleen is the largest secondary lymphoid organ with major roles in the removal of blood-borne antigens. The Eurasian moorhen is a wild aquatic bird that revealed the adaptation to harsh environmental conditions. Information regarding the structural features of moorhen's spleen is lacking. The present study aimed to describe the composition of moorhen's spleen using anatomical dissection, histology, histochemistry, immunohistochemistry, and transmission electron microscopy. The spleen appeared as a brownish red sickle-shaped organ close to the proventriculus and gizzard. The splenic capsule was very thin, and the trabeculae were poorly developed. The white pulp formed of the periarteriolar lymphoid sheath, lymphoid follicles, and periellipsoidal lymphatic sheath. The red pulp composed of sinusoids and cords and contained various types of blood cells. Blood vessels were observed within the splenic capsule and inside the parenchyma. Notably, penicillar capillaries (PCs) appeared branched and surrounded by welldeveloped ellipsoids. Direct connections were observed between PCs and splenic sinusoids suggesting a closed type of circulation. Ultrastructurally, intercellular spaces and vascular channels were evident in the wall of PCs. Ellipsoid-associated cells, lymphocytes, monocytes, and heterophils were observed within splenic ellipsoids. Ellipsoids were thus suggested as a crucial component of moorhen's spleen. Numerous MafB-immunoreactive (IR) macrophages were seen within the red pulp. Splenic cords contained the highest number of PHH3-IR cells, while CCASP3-IR cells were exclusive to follicles of the white pulp. In conclusion, the structure of moorhen's spleen revealed species-specific features.The findings of the present study could help to improve the immunity of domestic birds. Highlights• The Eurasian moorhen is a wild aquatic bird adapted to harsh environmental conditions with no known information about the cellular composition of its spleen.• The Eurasian moorhen's spleen revealed numerous penicillar capillaries surrounded by well-developed ellipsoids and appeared directly connected to the splenic sinusoids forming a closed type of circulation.• Immunohistochemical staining revealed site-specific staining for macrophages, proliferating, and apoptotic cells within moorhen's spleen.

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Role of MafB in macrophages

Cited by 54 publications

References 85 publications

c-MAF dependent perivascular macrophages regulate diet induced metabolic syndrome

c-MAF dependent perivascular macrophages regulate diet induced metabolic syndrome

PGE₂accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking

Structure of the Eurasian moorhen spleen: A comprehensive study using gross anatomy, light, and transmission electron microscopy

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Role of MafB in macrophages

Cited by 54 publications

References 85 publications

c-MAF dependent perivascular macrophages regulate diet induced metabolic syndrome

c-MAF dependent perivascular macrophages regulate diet induced metabolic syndrome

PGE2accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking

Structure of the Eurasian moorhen spleen: A comprehensive study using gross anatomy, light, and transmission electron microscopy

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PGE₂accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking