Role of Macrophage PIST Protein in Regulating Leishmania major Infection
Sourav Banerjee,
Mandip Pratham Gadpayle,
Suman Samanta
et al.
Abstract:PDZ protein interacting specifically with Tc10 or PIST is a mammalian trans-Golgi resident protein that regulates subcellular sorting of plasma membrane receptors. PIST has recently emerged as a key player in regulating viral pathogenesis. Nevertheless, the involvement of PIST in parasitic infections remains unexplored. Leishmania parasites infiltrate their host macrophage cells through phagocytosis, where they subsequently multiply within the parasitophorous vacuole (PV). Host cell autophagy has been found to… Show more
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