Role of lupeol and lupeol linoleate on lipemic–oxidative stress in experimental hypercholesterolemia

Sudhahar, Varatharajan; Kumar, Sekar Ashok; Varalakshmi, P.

doi:10.1016/j.lfs.2005.07.011

Cited by 80 publications

(62 citation statements)

References 45 publications

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“…The triterpenes Betulin and lupeol were isolated from Euclea natalensis by Weigenand et al (2004) and Khan and Rwekika (1992). According to Sudhahar et al (2006) lupeol and its derivative normalized the lipid profile in Wistar rats that were fed a high cholesterol diet. Ali et al (2006) also found that lupeol inhibited ␣-amylase enzyme.…”

Section: Discussionmentioning

confidence: 99%

Hypoglycaemic activity of four plant extracts traditionally used in South Africa for diabetes

Deutschländer

Venter

Roux

et al. 2009

Journal of Ethnopharmacology

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a b s t r a c tAim: To validate plant species for hypoglycaemic activity. Materials and methods: Four plants were investigated for hypoglycaemic activity by evaluating inhibiting effects on carbohydrate-hydrolising enzymes: ␣-glucosidase and ␣-amylase. Acetone plant extracts were screened against C2C12 myocytes, 3T3-L1 preadipocytes and Chang liver cells by measuring glucose uptake. Cytotoxicity was done in preadipocytes and hepatocytes. Results: Extract of Euclea undulata rootbark exhibited highest activity, displaying a glucose uptake of 162.2% by Chang liver cells at 50 g/ml. An inhibition concentration of 50% for Euclea undulata was found to be 49.95 g/ml for ␣-glucosidase and 2.8 g/ml for ␣-amylase. No cytotoxicity was recorded for Euclea undulata, while Schkuhria pinnata and Elaeodendron transvaalense exhibited cytotoxicity at 12.5 g/ml. ␣-Glucosidase and ␣-amylase assays showed inhibitory activity on enzymes for three plant extracts. Conclusion: Euclea undulata, Schkuhria pinnata and Elaeodendron transvaalense showed in vitro hypoglycaemic activity. Schkuhria pinnata and Elaeodendron transvaalense indicated cytotoxicity on 3T3-L1 preadipocytes and Chang liver cells. Euclea undulata, Pteronia divaricata and Elaeodendron transvaalense inhibited ␣-glucosidase and ␣-amylase enzymes. Ethnopharmacological relevance: Screening of plant extracts scientifically validated traditional use of Euclea undulata for treatment of diabetes. Cytotoxicity results revealed that acetone extracts of Schkuhria pinnata and Elaeodendron transvaalense are toxic and raise concern for chronic use.

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Section: Discussionmentioning

confidence: 99%

Hypoglycaemic activity of four plant extracts traditionally used in South Africa for diabetes

Deutschländer

Venter

Roux

et al. 2009

Journal of Ethnopharmacology

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“…An earlier study on lupeol and its ester lupeol linoleate, pentacyclic triterpenes derived from C. nurvala bark reduced the lipid abnormalities and hypercholesterolemia in rats fed with high cholesterol diet (Sudhahar et al 2006). On the similar grounds in our study, both CNet 400 and CNet 600 containing triterpenes, shown reduction in cholesterol levels in comparison with LT 4 treated group which can control CHO levels on long term therapy, along with dietary restriction and with use of hypolipidemic agents only (O'Brein et al, 1993;Tanis et al, 1996) and vehicle treated hypothyroid group.…”

Section: Discussionmentioning

confidence: 93%

Potential Thyrotropic and Antihypercholesteronemic Activity Exhibited by Ethanolic Extract of Crataeva nurvala Bark

2017

J App Pharm Sci

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Charaka, supports that the imbalance (Ojus) between the three bodily humours (doshas), along with the fat (Meda) leads to enlargement of the thyroid gland (Galaganda) and metabolic syndrome. This study aims to evaluate the effect of the ethanolic extract of Crataeva nurvala (CNet) bark, on free thyroxine (FT4), thyroid stimulating hormone (TSH) and serum cholesterol (CHO) in Swiss albino female adult mice over conventional therapy. In this study, the animals were divided into four groups who were made hypothyroid using 6-propyl-2-thiouracil (PTU) for first 15 days and then Group I, treated with vehicle, Group II, treated with LT4 (14.56 µg/kg), Group III, treated with CNet 400 mg/kg and Group IV treated with CNet 600 mg/kg (p.o.) for another 15 days. The variation in the biochemical parameters was recorded on Day 15 th and Day 30 th . The results were expressed as mean ± SEM, using two-way ANOVA followed by Bonferroni posttests. In comparison with the standard i.e. LT4, significant (***P<0.001) thyroid stimulant activity was shown by CNet 600 mg/kg, with significant reduction in cholesterol levels whereas, less marked and erratic response with CNet 400 mg/kg was received. Crataeva nurvala was found effective at higher dose, that suggest its beneficial role in treating hypothyroidism and associated hypercholesteronemia.

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“…40,41 The HA root has been reported to have chemoprotective activity in cyclophosphamide-induced toxicity. 42 Many studies have validated the role of β-sitosterol and lupeol in the management of diabetes and hypercholesterolemia. 17,41 β-sitosterol has been shown to normalize blood sugar and insulin levels in type 2 diabetics.…”

Section: Discussionmentioning

confidence: 99%

“…Also the roots are reported to contain β-sitosterol, lupeol, and alpha-amyrin as the main constituents which are reported to have both antioxidant and antidiabetic properties. 16,17 The roots of this plant are also reported to have an antidiabetic effect in streptozotocin-induced diabetic rats (Type-1). 18 However, there is no available evidence of such an effect of HA root in type 2 diabetes or an insulin resistant animal model.…”

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confidence: 99%

Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice

Ibrahim¹

2010

DMSOTT

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Abstract:The roots of Holostemma annularis K. Schum (Asclepiadacae) are used in traditional medicine to treat diabetes. This medicinal plant, widely used in more than 34 ayurvedic preparations, was evaluated in a high fructose diet in induced insulin resistance and in C57BL/6J ob/ob diabetic mice for its antidiabetic activity. Graded doses of both chloroform and methanolic extracts of the roots of H. annularis were administered to normal and experimental diabetic rats for 21 days. Serum glucose, triglycerides, cholesterol levels and total protein in urine were analyzed. Significant results were observed in the estimated parameters. These data justify the use of the plant in the treatment of diabetes mellitus and is a potential source for the isolation of new active agents for diabetes mellitus.

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Role of lupeol and lupeol linoleate on lipemic–oxidative stress in experimental hypercholesterolemia

Cited by 80 publications

References 45 publications

Hypoglycaemic activity of four plant extracts traditionally used in South Africa for diabetes

Hypoglycaemic activity of four plant extracts traditionally used in South Africa for diabetes

Potential Thyrotropic and Antihypercholesteronemic Activity Exhibited by Ethanolic Extract of Crataeva nurvala Bark

Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice

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