Role of Loop Ileostomy in the Management of Ulcerative Colitis Patients

Hussein, Ahmed N.

doi:10.47723/kcmj.v15i2.166

Cited by 2 publications

(1 citation statement)

References 14 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inflammatory bowel disease (IBD) includes both Crohn's disease (CD) and ulcerative colitis (UC). UC is a progressive disease of the gastrointestinal tract (GIT) that has a chronic nature and mainly affects the large intestine (1,2). In UC, the stimulation of white blood cells arises after bacterial imbalance and infection in the gut, along with an impaired mucosal barrier.…”

Section: Introduction Introductionmentioning

confidence: 99%

Impact of Cyclooxygenase-2 Polymorphism -765G>C (rs20417) on the Development of Ulcerative Colitis

Alahmed,

A. Al-Rubaee

2023

SGO

View full text Add to dashboard Cite

Background: Ulcerative Colitis is chronic, progressive disease affecting large intestine. Cyclooxygenase-2 enzyme is an inducible enzyme that has important role in the process of inflammation. Ulcerative Colitis pathogenesis is comprising chronic inflammation; any alteration in the gene responsible for cuclooxygenase-2 expression such as -765G>C (rs20417) polymorphism may affect risk of having the disease. Objectives: To record and evaluate the prevalence of -765G>C (rs20417) polymorphism in group of Ulcerative Colitis Iraqi patients and correlation it with disease clinical severity. Method: A case-control, single-center study included ninety participants collected from Gastroenterology and Hepatology Hospital/Basrah/Iraq, divided in to 30 newly diagnosed patients, 30 previously diagnosed patients and 30 healthy controls. Genetic analysis done through dual color discrimination assay. Results: To our knowledge the present study is the first report in Iraqi population that investigates the correlation between COX-2 polymorphism, rs20417 with risk of developing UC. The prevalence of the -765G and -765C alleles was 85.8% and 14.1% in the patient group and 86.6% and 13.3% in the control group respectively, the -765CC variant in Basrah city was infrequent in population of UC patients (14.1%) and in controls (13.3%). There was no statistical difference in the disease association and in the relationship to the disease severity but GG genotypes showed more sever clinical disease than those with other variants. Conclusion:In disparity to other reports on the role of COX-2 polymorphisms at position -765 in the term of modifying the risk for UC in a group of Arab Iraqi patients, we did not find significant results for this variation's association but in term of association with the level of disease clinical severity, carriers of GG wild type had more active clinical disease than those with mutant variants.

show abstract

Section: Introduction Introductionmentioning

confidence: 99%

Impact of Cyclooxygenase-2 Polymorphism -765G>C (rs20417) on the Development of Ulcerative Colitis

Alahmed,

A. Al-Rubaee

2023

SGO

View full text Add to dashboard Cite

show abstract

Salivary trace elements in patients with ulcerative colitis on different treatment modalities

Talib,

Fadhil Zaidan

2023

View full text Add to dashboard Cite

The nutritional status of patients with inflammatory bowel disease is considered less than ideal. This study aimed to compare the salivary levels of some trace elements (Zinc, copper, and magnesium) in patients with ulcerative colitis (UC) on two different therapeutic modalities to control subjects. Materials and methods: This cross-sectional study was performed in 2021-2022 on 53 diagnosed UC patients (27 UC patients on oral immunosuppressant therapy and 26 UC patients on combination therapy). All subjects were randomly selected from gastroenterology and Hepatology teaching hospitals in Baghdad city; twenty-five subjects were also recruited as controls. Demographic data were recorded through a checklist. Salivary levels of zinc (Zn), copper (Cu) and magnesium (Mg) were measured by atomic absorption spectroscopy. Data were analyzed using SPSS-28 at a significance level of 0.05. The results: Salivary Zn mean was significantly lower in monotherapy and combination therapy patients than in controls (p<0.001). Mean salivary Cu levels were significantly higher in monotherapy and combination therapy patients than in controls (p<0.001). Similarly, the salivary Mg mean was significantly lower in both groups of ulcerative colitis patients than in controls (p<0.001). The mean of salivary Cu was higher in UC patients, while the men of Zn and Mg were lower in UC patients compared to controls. Conclusions: The results showed that UC patients have significantly lower Zn and Mg levels than healthy individuals and were lower inpatient on monotherapy than in combination. At the same time, salivary Cu in UC patients was higher than in control individuals and was higher in UC patients on monotherapy. Keywords: Inflammatory bowel diseases, Ulcerative colitis, Trace elements

show abstract

Role of Loop Ileostomy in the Management of Ulcerative Colitis Patients

Cited by 2 publications

References 14 publications

Impact of Cyclooxygenase-2 Polymorphism -765G>C (rs20417) on the Development of Ulcerative Colitis

Impact of Cyclooxygenase-2 Polymorphism -765G>C (rs20417) on the Development of Ulcerative Colitis

Salivary trace elements in patients with ulcerative colitis on different treatment modalities

Contact Info

Product

Resources

About