Role of long-term potentiation in mechanism of the conditioned learning

Tsvetkov, Evgeny; Suderevskaya, E. I.; Vesselkin, N. P.

doi:10.1134/s0022093011030017

Cited by 1 publication

(1 citation statement)

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“…The behavioral research, together with our previous results, further supports our previous hypotheses that Aβ25–35 could seriously impair spatial learning and memory in rats. In view of the close association between the spatial memory and the hippocampal synaptic plasticity, hippocampal LTP has been widely viewed as one of the major cellular mechanisms underlying learning and memory (Shiosaka and Ishikawa, ; Tsvetkov et al, ). The impairment of LTP by Aβ1–40 and Aβ1–42 has been reported (Srivareerat et al, ; Nomura et al, ).…”

Section: Discussionmentioning

confidence: 99%

Colivelin ameliorates amyloid β peptide-induced impairments in spatial memory, synaptic plasticity, and calcium homeostasis in rats

Zhou

Wang

et al. 2014

Hippocampus

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Amyloid β peptide (Aβ) has been thought to be neurotoxic and responsible for the impairment of learning and memory in Alzheimer's disease (AD). Humanin (HN), a 24 amino acid polypeptide first identified from the unaffected occipital lobe of an AD patient, is believed to be neuroprotective against the AD-related neurotoxicity. In this study, we investigated the neuroprotective effects of Colivelin (CLN), a novel HN derivative, against Aβ by using behavioral test, in vivo electrophysiological recording, and intracellular calcium imaging. Our results showed that intrahippocampal injection of CLN (0.2 nmol) effectively prevented Aβ25-35 (4 nmol)-induced deficits in spatial learning and memory of rats in Morris water maze test; the suppression of in vivo hippocampal long term potentiation (LTP) by Aβ25-35 was nearly completely prevented by CLN; in addition, CLN pretreatment also effectively inhibited Aβ25-35-induced calcium overload in primary cultured hippocampal neurons. These results indicate that CLN has significant neuroprotective properties against Aβ, and CLN may holds great promise for the treatment and prevention of AD.

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Section: Discussionmentioning

confidence: 99%