Role of Long Non-Coding RNAs in Reprogramming to Induced Pluripotency

Kanwal, Shahzina; Guo, Xiangpeng; Ward, Carl; Volpe, Giacomo; Qin, Baoming; Esteban, Miguel A.; Bao, Xichen

doi:10.1016/j.gpb.2019.06.003

Cited by 10 publications

(12 citation statements)

References 109 publications

(141 reference statements)

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“…With the development of next-generation sequencing technology, lncRNA has become a hot spot in the field of non-coding RNA research in recent years. LncRNA can regulate gene expression in various ways and is widely involved in the up-regulation or down-regulation of oncogenes or tumor suppressor genes and plays a very important regulatory function in various physiological and pathological activities such as cell differentiation, proliferation, metabolism, apoptosis, and senescence (Ji et al, 2020;Kanwal et al, 2020). The differential expression of lncRNA in malignant tumors and the molecular mechanism of action have been gradually investigated, and more and more lncRNAs have been found to be closely related to the occurrence and development of tumors.…”

Section: Discussionmentioning

confidence: 99%

LINC00511/miRNA-143-3p Modulates Apoptosis and Malignant Phenotype of Bladder Carcinoma Cells via PCMT1

Dong

Zhang

Mao

et al. 2021

Front. Cell Dev. Biol.

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Bladder cancer has easy recurrence characteristics, but its occurrence and development mechanism are still unclear. Non-coding RNA is a kind of RNA that exists widely and cannot be translated into proteins, which has played a key role in the regulation of biological functions of tumor cells. However, the regulation mechanism of non-coding RNA on bladder tumors is not fully understood. By microarray analysis and database analysis, we found that LINC00511 was significantly highly expressed in bladder cancer. The expressions of LINC00511, miR-143-3p, and PCMT in bladder cancer tissues and cells were detected by quantitative reverse transcription–polymerase chain reaction. The relationship between the expressions of miR-143-3p and PCMT1 and the clinicopathological parameters of the tumor was analyzed. The proliferation and invasion of bladder cancer cells were detected by MTT assay and Transwell assay. The expression levels of E-cadherin and vimentin in bladder cancer cells were detected by Western blot. Cell apoptosis was detected by flow cytometry. In vivo, TCCSUP or SW780 cells were inoculated into BALB/c nude mice to detect tumor volume and weight. Bioinformatics and dual luciferase reporter gene were used to analyze the relationship between LINC00511 and miR-143-3p and its downstream target gene PCMT1. The results showed that LINC00511 could target miR-143-3p/PCMT1 to regulate the proliferation, migration, and apoptosis of bladder cancer TCCSUP or SW780 cells and promote the occurrence and development of bladder cancer.

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Section: Discussionmentioning

confidence: 99%

LINC00511/miRNA-143-3p Modulates Apoptosis and Malignant Phenotype of Bladder Carcinoma Cells via PCMT1

Dong

Zhang

Mao

et al. 2021

Front. Cell Dev. Biol.

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“…lincRNA-1526 and lincRNA-1463 are associated with inverse regulation of the activation of the pluripotency genes in reprogramming, while lincRNA-1307 and ladr49/83 can positively regulate the pluripotency genes. LNCPRESS1, Snhg14, Gas5 and Peblr20 are positive regulators of the pluripotency genes in reprogramming and/or embryonic stem cells(ESCs) ( 182 ). Moreover, there are novel approaches to comprehend regulation of the lncRNAs.…”

Section: Biogenesis and Function Of Lncrnas And Lncrnas-mediated Prog...mentioning

confidence: 99%

Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions

2022

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Oral cancer remains a major public concern with considerable socioeconomic impact in the world. Despite substantial advancements have been made in treating oral cancer, the five-year survival rate for oral cancer remained undesirable, and the molecular mechanisms underlying OSCC carcinogenesis have not been fully understood. Noncoding RNAs (ncRNAs) include transfer RNAs (tRNAs), as well as small RNAs such as microRNAs, and the long ncRNAs such as HOTAIR are a large segment of the transcriptome that do not have apparent protein-coding roles, but they have been verified to play important roles in diverse biological processes, including cancer cell development. Cell death, such as apoptosis, necrosis, and autophagy, plays a vital role in the progression of cancer. A better understanding of the regulatory relationships between ncRNAs and these various types of cancer cell death is therefore urgently required. The occurrence and development of oral cancer can be controlled by increasing or decreasing the expression of ncRNAs, a method which confers broad prospects for oral cancer treatment. Therefore, it is urgent for us to understand the influence of ncRNAs on the development of different modes of oral tumor death, and to evaluate whether ncRNAs have the potential to be used as biological targets for inducing cell death and recurrence of chemotherapy. The purpose of this review is to describe the impact of ncRNAs on cell apoptosis and autophagy in oral cancer in order to explore potential targets for oral cancer therapy.

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“…LncRNAs promote cancer stem cells stemness and drug resistance [ 32 ]. In addition, lncRNAs regulate cell reprogramming, altering the transcriptome [ 33 ].…”

Section: Long Non-coding Rnas and Potential Therapeutic Targeting In ...mentioning

confidence: 99%

The Regulatory Functions and the Mechanisms of Long Non-Coding RNAs in Cervical Cancer

Yang

Al-Hendy

2022

Cells

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Cervical cancer is one of the leading causes of death in gynecology cancer worldwide. High-risk human papillomaviruses (HPVs) are the major etiological agents for cervical cancer. Still, other factors also contribute to cervical cancer development because these cancers commonly arise decades after initial exposure to HPV. So far, the molecular mechanisms underlying the pathogenesis of cervical cancer are still quite limited, and a knowledge gap needs to be filled to help develop novel strategies that will ultimately facilitate the development of therapies and improve cervical cancer patient outcomes. Long non-coding RNAs (lncRNAs) have been increasingly shown to be involved in gene regulation, and the relevant role of lncRNAs in cervical cancer has recently been investigated. In this review, we summarize the recent progress of ascertaining the biological functions of lncRNAs in cervical cancer, from the perspective of cervical cancer proliferation, invasion, and metastasis. In addition, we provide the current state of knowledge by discussing the molecular mechanisms underlying the regulation and emerging role of lncRNAs in the pathogenesis of cervical cancer. Comprehensive and deeper insights into lncRNA-mediated alterations and interactions in cellular events will help develop novel strategies to treat patients with cervical cancer.

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Role of Long Non-Coding RNAs in Reprogramming to Induced Pluripotency

Cited by 10 publications

References 109 publications

LINC00511/miRNA-143-3p Modulates Apoptosis and Malignant Phenotype of Bladder Carcinoma Cells via PCMT1

LINC00511/miRNA-143-3p Modulates Apoptosis and Malignant Phenotype of Bladder Carcinoma Cells via PCMT1

Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions

The Regulatory Functions and the Mechanisms of Long Non-Coding RNAs in Cervical Cancer

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