Role of long non-coding RNA H19 in the development of osteoporosis

Chen, Senxiang; Liu, Da; Zhou, Zimo; Qin, Sen

doi:10.1186/s10020-021-00386-0

Cited by 23 publications

(10 citation statements)

References 90 publications

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“…The incidence of osteoporosis is 70% in people aged over 80 years and 15% in people over 50 years [ 3 ]. At present, there are more than 200 million patients suffering from osteoporosis worldwide; as life expectancy increases globally, osteoporosis will lead to increased financial and medical burdens in most countries, and it is expected that the global cost of osteoporosis may increase to $131.5 billion by 2050 [ 4 ]. Fragility fractures caused by low-energy trauma, particularly hip fracture, are common complications of osteoporosis that result in poor health-related quality of life and a high risk of disability and mortality [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

STAT3-mediated osteogenesis and osteoclastogenesis in osteoporosis

Hou

Tian

2022

Cell Commun Signal

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Osteoporosis is a common skeletal disease with marked bone loss, deterioration of the bone microstructure and bone fragility. An abnormal bone remodelling cycle with relatively increased bone resorption is the crucial pathophysiological mechanism. Bone remodelling is predominantly controlled by osteoblasts and osteoclasts, which are specialized cell types that are regulated by a variety of osteogenic and osteoclastic factors, including cytokines expressed within the bone microenvironment under local or systemic inflammatory conditions. Signal transducer and activator of transcription 3 (STAT3) plays a prominent role in the communication between cytokines and kinases by binding downstream gene promotors and is involved in a wide range of biological or pathological processes. Emerging evidence suggests that STAT3 and its network participate in bone remodelling and the development of osteoporosis, and this factor may be a potent target for osteoporosis treatment. This review focuses on the role and molecular mechanism of the STAT3 signalling pathway in osteogenesis, osteoclastogenesis and osteoporosis, particularly the bone-related cytokines that regulate the osteoblastic differentiation of bone marrow stromal cells and the osteoclastic differentiation of bone marrow macrophages by initiating STAT3 signalling. This review also examines the cellular interactions among immune cells, haematopoietic cells and osteoblastic/osteoclastic cells.

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Section: Introductionmentioning

confidence: 99%

STAT3-mediated osteogenesis and osteoclastogenesis in osteoporosis

Hou

Tian

2022

Cell Commun Signal

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“…lnRNAs, due to their size (>200 kb), fold into secondary or tertiary structures to make them more flexible to target proteins. It has been discovered that lncRNA H19 plays a part in the control of various cell types in the body, including the osteoblasts, osteocytes, and osteoclasts found in bones (Chen et al, 2021). Therefore, it is conceivable that lncRNA H19 influences the occurrence and progression of osteoporosis.…”

Section: Regulation Of Osteoclastogenesismentioning

confidence: 99%

Fine‐tuning osteoclastogenesis: An insight into the cellular and molecular regulation of osteoclastogenesis

Anwar

Sapra

Gupta

et al. 2023

Journal Cellular Physiology

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Osteoclasts, the bone-resorbing cells, are essential for the bone remodeling process and are involved in the pathophysiology of several bone-related diseases. The extensive corpus of in vitro research and crucial mouse model studies in the 1990s demonstrated the key roles of monocyte/macrophage colony-stimulating factor, receptor activator of nuclear factor kappa B ligand (RANKL) and integrin αvβ3 in osteoclast biology. Our knowledge of the molecular mechanisms by which these variables control osteoclast differentiation and function has significantly advanced in the first decade of this century. Recent developments have revealed a number of novel insights into the fundamental mechanisms governing the differentiation and functional activity of osteoclasts; however, these mechanisms have not yet been adequately documented. Thus, in the present review, we discuss various regulatory factors including local and hormonal factors, innate as well as adaptive immune cells,noncoding RNAs (ncRNAs), etc., in the molecular regulation of the intricate and tightly regulated process of osteoclastogenesis. ncRNAs have a critical role as epigenetic controllers of osteoclast physiologic activities, including differentiation and bone resorption. The primary ncRNAs, which include micro-RNAs, circular RNAs, and long noncoding RNAs, form a complex network that affects gene transcription activities associated with osteoclast biological activity. Greater knowledge of the involvement of ncRNAs in osteoclast biological activities will contribute to the treatment and management of several skeletal diseases such as osteoporosis, osteoarthritis, rheumatoid arthritis, etc. Moreover, we further outline potential therapies targeting these regulatory pathways of osteoclastogenesis in distinct bone pathologies.

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“…For instance, lncRNAs MALAT1, TUG1, and HOTAIR were reported to promote osteogenesis and bone formation [ 17 – 19 ]. As one of the earliest discovered lncRNAs, H19 plays crucial roles in various physiological and pathological activities [ 20 – 22 ]. Our previous study found that H19 promoted osteoblast differentiation through activating Wnt/ β -catenin signaling [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Aucubin Promotes Osteogenic Differentiation and Facilitates Bone Formation through the lncRNA‐H19 Driven Wnt/β‐Catenin Signaling Regulatory Axis

Mai,

Li,

Pang

et al. 2024

Stem Cells International

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Objectives. Traditional Chinese medicine Cortex Eucommiae has been used to treat bone fracture for hundreds of years, which exerts a significant improvement in fracture healing. Aucubin, a derivative isolated from Cortex Eucommiae, has been demonstrated to possess anti-inflammatory, immunoregulatory, and antioxidative potential. In the present study, our aim was to explore its function in bone regeneration and elucidate the underlying mechanism. Materials and Methods. The effects of Aucubin on osteoblast and osteoclast were examined in mouse bone marrow-derived mesenchymal stem cells (BM-MSCs) and RAW 264.7 cells, respectively. Moreover, the lncRNA H19 and Wnt/β-catenin signaling were detected by qPCR examination, western blotting, and luciferase activity assays. Using the femur fracture mice model, the in vivo effect of Aucubin on bone formation was monitored by X-ray, micro-CT, histomorphometry, and immunohistochemistry staining. Results. In the present study, Aucubin was found to significantly promote osteogenic differentiation in vitro and stimulated bone formation in vivo. Regarding to the underlying mechanism, H19 was found to be obviously upregulated by Aucubin in MSCs and thus induced the activation of Wnt/β-catenin signaling. Moreover, H19 knockdown partially reversed the Aucubin-induced osteogenic differentiation and successfully suppressed the activation of Wnt/β-catenin signaling. We therefore suggested that Aucubin induced the activation of Wnt/β-catenin signaling through promoting H19 expression. Conclusion. Our results demonstrated that Aucubin promoted osteogenesis in vitro and facilitated fracture healing in vivo through the H19-Wnt/β-catenin regulatory axis.

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Role of long non-coding RNA H19 in the development of osteoporosis

Cited by 23 publications

References 90 publications

STAT3-mediated osteogenesis and osteoclastogenesis in osteoporosis

STAT3-mediated osteogenesis and osteoclastogenesis in osteoporosis

Fine‐tuning osteoclastogenesis: An insight into the cellular and molecular regulation of osteoclastogenesis

Aucubin Promotes Osteogenic Differentiation and Facilitates Bone Formation through the lncRNA‐H19 Driven Wnt/β‐Catenin Signaling Regulatory Axis

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