Role of long-lasting neuromuscular depression in muscle activity in crayfish

Czternasty, G.; Bruner, J.; Galeano, C.

doi:10.1016/0306-4492(80)90114-8

Cited by 5 publications

(4 citation statements)

References 15 publications

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“…These different patterns of responses are likely to result from the different nature of the presynaptic sites, since both MoG and the nongiant fast flexor motor neurons utilize L-glutamate as an excitatory transmitter and no desensitization was observed in the flexor muscle when L-glutamate was applied locally at an interval of 10 s. The duration of the depression in the flexor muscle was rather short and the amplitude of the EJP in the flexor muscle recovered to the level of initial stimulation within 15 min. Furthermore, lowering the temperature decreases the magnitude of the depression in crayfish neuromuscular synapses (Thies, 1965;Czternasty and Bruner, 1980). These facts suggest that certain metabolic factors may induce depression.…”

Section: Ejp Depression In Response To Mog Stimulationmentioning

confidence: 94%

“…Depression is thought to be dependent on the availability of Ca2+ in the neuromuscular terminals (Czternasty and Bruner, 1980). In both the crayfish and lobster neuromuscular junction, L-glutamate is known to affect presynaptic autoreceptors that regulate the release of transmitter by changing the amount of transmitter content in each vesicle (Thieffry and Bruner, 1978;Miwa et al, 1990;Parnas et al, 1996).…”

Section: Ejp Depression In Response To Mog Stimulationmentioning

confidence: 99%

“…Although the initial excitatory junctional potential (EJP) elicited by MoG stimulation produces a twitch in the fast flexor muscle, subsequent stimuli at low-frequency intervals cause significant depression of the response in the flexor muscle (Bruner and Kennedy, 1970;Dumont and Wine, 1987). Many investigators have studied the synaptic mechanism of this depression (e.g., Kennedy and Takeda, 1965;Zucker and Bruner, 1977;Czternasty and Bruner, 1980;Czternasty et al, 1980). However, no systematic study has been made of the neurotransmitter substance used by MoG.…”

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confidence: 98%

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L-glutamate as an Excitatory Transmitter of Motor Giant Neurons in the Crayfish Procambarus Clarkii

Aonuma

Nagayama

Takahata

1998

Journal of Crustacean Biology

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Section: Ejp Depression In Response To Mog Stimulationmentioning

confidence: 94%

Section: Ejp Depression In Response To Mog Stimulationmentioning

confidence: 99%

mentioning

confidence: 98%

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L-glutamate as an Excitatory Transmitter of Motor Giant Neurons in the Crayfish Procambarus Clarkii

Aonuma

Nagayama

Takahata

1998

Journal of Crustacean Biology

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“…4 inset). This was a first indication that habituation should not be mainly attributed to muscle fatigue or to synaptic depression at the neuromuscular junction (Czternasty et al, 1980;Hawkins and Bruner, 1981). It did not exclude a possible contribution of inhibitory input to the muscle (but see below).…”

Section: Stimulus Artefact Loomsmentioning

confidence: 96%

Correlates of Habituation of a Polysynaptic Reflex in Crayfish In Vivo and In Vitro

Marchand

Barnes

1992

Eur J of Neuroscience

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Reflex leg levation habituates during repeated electrical stimulation of mechanosensory afferents in the dactyl of the fifth walking leg of the crayfish, Procambarus clarkii. This was investigated in decerebrate crayfish, and reproduced in an isolated thoracic ganglion preparation. In vivo, trains of stimuli delivered every 2.5 s produced a gradual decrease in the amplitude of the mechanical response, and a concomitant decrease in the number of impulses per burst in the levator muscle myogram. Near complete recovery occurred after 10 min rest, and transient dishabituation was observed after electrical stimulation of the telson. Less frequent or stronger stimuli led to less rapid habituation. In vitro, the same parametric characteristics of habituation were observed in the levator nerve responses, while the intrinsic variability of the reflex was reduced. The response decrement was shown to be unrelated to changes in the afferent excitation. Evoked polysynaptic excitatory postsynaptic potentials (EPSPs) in levator motorneurons decreased in parallel with the levator neurogram. This decrease was unrelated to any change in the resting membrane potential of the levator motorneurons. Interneurons with habituating EPSPs, antagonistic depressor motorneurons with habituating inhibitory postsynaptic potentials and non-habituating responses in other motorneuronal groups were also found. These findings point to a central locus of habituation upstream from the motorneurons, and offer prospects for a detailed investigation of the mechanisms of habituation in a polysynaptic system.

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Analysis of synaptic depression contributing to habituation of gill-withdrawal reflex in Aplysia californica

Byrne¹

1982

Journal of Neurophysiology

106

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1. Repeated stimulation of the siphon skin results in short-term habituation of the reflex contractions of the gill (38). The habituation, in turn, is correlated with a depression of the excitatory postsynaptic potentials (EPSPs) in motor neurons from mechanoreceptor sensory neurons (SN) (7, 16). The present study was undertaken to examine the parametric features of the synaptic depression and gain insights into the mechanisms underlying the reduced transmitter release. 2. Single sensory neuron action potentials were repeatedly elicited with depolarizing current pulses while the amplitude of the resultant EPSPs in the motor neuron was monitored. Synaptic depression varies as a complex function of interstimulus interval (ISI). At an ISI of 1 s, depression is rapid and reaches a plateau at 36% of control. In contrast, the depression at an ISI of 100 s is less pronounced, showing a gradual decay to 65% of control with the 10th EPSP. Surprisingly, there are no significant differences in time course or magnitude of depression across a broad range of intermediate ISIs (3, 10, and 30 s), although depression at these ISIs is intermediate between the 1 and 100 s ISIs. 3. There is also a complex relationship between spike interval and the depression of the second of two EPSPs. Thus, depression of the second of two EPSPs or depression of a train of EPSPs is not a monotonic function of spike interval. Indeed, the data suggest that there may be a slight underlying facilitatory process with short spike intervals. 4. The results also indicate that the recovery of synaptic depression following a train of 10 stimuli is not constant. Shorter spike intervals produce more rapid recovery. 5. These data are inconsistent with a classical depletion model (33) for synaptic depression and indicate that either a single complex function of time and ISI or multiple functions underlie synaptic depression and its recovery at the sensory neuron synapse.

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Role of long-lasting neuromuscular depression in muscle activity in crayfish

Cited by 5 publications

References 15 publications

L-glutamate as an Excitatory Transmitter of Motor Giant Neurons in the Crayfish Procambarus Clarkii

L-glutamate as an Excitatory Transmitter of Motor Giant Neurons in the Crayfish Procambarus Clarkii

Correlates of Habituation of a Polysynaptic Reflex in Crayfish In Vivo and In Vitro

Analysis of synaptic depression contributing to habituation of gill-withdrawal reflex in Aplysia californica

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