Role of lncRNAs in hepatocellular carcinoma

Nanotherapeutic approaches for delivery of long non-coding RNAs: an updated review with emphasis on cancer

“…Through distinct mechanisms, lncRNA regulates the expression and activity of several molecules during oncogenesis and cancer progression, including mRNAs, miRNAs, and proteins. 136 The expression of SENP3-EIF4A1 in healthy controls and HCC patients was compared in 2020. Exosomal SENP3-EIF4A1 is a protein secreted by normal cells and inhibits the biologically malignant nature of HCC cells by promoting apoptosis and decreasing migration and invasion.…”

The role of lncRNA-mediated ceRNA regulatory networks in liver fibrosis

“…This highlights the need for further study of lncRNAs acting as competing ceRNAs in the initiation and progression of liver fibrosis. The pathophysiology of liver fibrosis is regulated by networks including miRNAs and signaling pathways such as miR-126/(NF-ĸB and Wnt inhibitory factor 1 (WIF1)), miR-200c/(FOG2, epidermal growth factor (EGF), phosphoinositide 3 - kinases (PI3Ks) and AKT) and miR-31/(Smad3, TGF-β and hypoxia-inducible factor-1 (HIF-1)), among others [ 17 , 18 , 24 , 31 , 55 ]. LncRNAs, as hypothetical ceRNAs, influence mRNA expression by competitively interacting with microRNAs.…”

“…In the context of competing endogenous RNAs (ceRNAs), lncRNAs contribute to extensive regulatory networks spanning the transcriptome, substantially expanding the functional genetic information encoded in the human genome. This diversified group of molecules plays a pivotal role in various pathological conditions [ [23] , [24] , [25] , [26] , [27] , [28] ] ( Fig. 1 ).…”

LINC01134: a pivotal oncogene with promising predictive maker and therapeutic target in hepatocellular carcinoma

“…Emerging data highlight the significant role of lncRNAs in human pathologies ( 23 – 25 ), especially in malignant tumors ( 26 – 29 ). Dysregulation of lncRNAs has been closely linked to tumor growth, metastasis, and resistance to chemotherapy ( 30 – 34 ), radiotherapy ( 35 – 38 ), and immune responses ( 39 – 41 ), underscoring their crucial involvement in cancer development.…”