2020
DOI: 10.3389/fgene.2020.584118
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Role of LncRNAs and CircRNAs in Bone Metabolism and Osteoporosis

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Cited by 37 publications
(32 citation statements)
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“…However, as the pathophysiology of osteoporosis differs among persons, treatments can produce unwanted side effects. The role of different non-coding RNAs, such as micro-, lnc-, and circ-RNA, in regulating bone cell survival, proliferation, differentiation, and apoptosis, has been extensively summarized and therefore can be employed not only as therapeutic, but also targets to improve bone health [ 160 , 161 ]. Different delivery systems developed for targeted gene delivery in different organs, including bone, has opened new opportunities in gene engineering and the preliminary works on microRNA and SiRNA-based gene delivery systems in bone have shown promising results in improving bone microarchitecture and BMD in osteoporosis mice [ 162 ].…”
Section: Discussionmentioning
confidence: 99%
“…However, as the pathophysiology of osteoporosis differs among persons, treatments can produce unwanted side effects. The role of different non-coding RNAs, such as micro-, lnc-, and circ-RNA, in regulating bone cell survival, proliferation, differentiation, and apoptosis, has been extensively summarized and therefore can be employed not only as therapeutic, but also targets to improve bone health [ 160 , 161 ]. Different delivery systems developed for targeted gene delivery in different organs, including bone, has opened new opportunities in gene engineering and the preliminary works on microRNA and SiRNA-based gene delivery systems in bone have shown promising results in improving bone microarchitecture and BMD in osteoporosis mice [ 162 ].…”
Section: Discussionmentioning
confidence: 99%
“…LncRNAs are non-coding RNA transcripts that constitute more than 200 nucleotides and regulate target gene expression via cis- or transregulation. [ 93 ]. It has been reported that the overexpression of lncRNA AK077216 during osteoclastogenesis promotes osteoclast differentiation and bone resorption by suppressing NIP45 and promoting NFATc1 expression [ 94 ].…”
Section: The Role Of Molecules In Osteoclast Regulationmentioning
confidence: 99%
“…CircRNA regulates cellular transcription, posttranslational expression, by interacting with miRNAs. CircRNAs are directly involved in bone-related signal transduction, forming a circRNA-miRNA-mRNA axis to work in bone remodeling [ 93 , 100 ]. During RANKL + CSF1-induced BMM differentiation to osteoclast, circRNA_28313 level was elevated.…”
Section: The Role Of Molecules In Osteoclast Regulationmentioning
confidence: 99%
“…And it is excluded repeated parts of previous reports, [123][124][125] such as DANCR, 126 ORLNC1 127 and XIST. 128 Researchers have systematically summarized these lncRNAs.…”
Section: The Role Of Lncrnas In Osteoclastogenesismentioning
confidence: 99%