Role of LncRNAs and CircRNAs in Bone Metabolism and Osteoporosis

Patil, Suryaji; Dang, Kai; Zhao, Xiulan; Gao, Yongguang; Qian, Airong

doi:10.3389/fgene.2020.584118

Cited by 37 publications

(32 citation statements)

References 129 publications

(111 reference statements)

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“…However, as the pathophysiology of osteoporosis differs among persons, treatments can produce unwanted side effects. The role of different non-coding RNAs, such as micro-, lnc-, and circ-RNA, in regulating bone cell survival, proliferation, differentiation, and apoptosis, has been extensively summarized and therefore can be employed not only as therapeutic, but also targets to improve bone health [ 160 , 161 ]. Different delivery systems developed for targeted gene delivery in different organs, including bone, has opened new opportunities in gene engineering and the preliminary works on microRNA and SiRNA-based gene delivery systems in bone have shown promising results in improving bone microarchitecture and BMD in osteoporosis mice [ 162 ].…”

Section: Discussionmentioning

confidence: 99%

The Development of Molecular Biology of Osteoporosis

Gao

Patil

Jia

2021

IJMS

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Osteoporosis is one of the major bone disorders that affects both women and men, and causes bone deterioration and bone strength. Bone remodeling maintains bone mass and mineral homeostasis through the balanced action of osteoblasts and osteoclasts, which are responsible for bone formation and bone resorption, respectively. The imbalance in bone remodeling is known to be the main cause of osteoporosis. The imbalance can be the result of the action of various molecules produced by one bone cell that acts on other bone cells and influence cell activity. The understanding of the effect of these molecules on bone can help identify new targets and therapeutics to prevent and treat bone disorders. In this article, we have focused on molecules that are produced by osteoblasts, osteocytes, and osteoclasts and their mechanism of action on these cells. We have also summarized the different pharmacological osteoporosis treatments that target different molecular aspects of these bone cells to minimize osteoporosis.

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Section: Discussionmentioning

confidence: 99%

The Development of Molecular Biology of Osteoporosis

Gao

Patil

Jia

2021

IJMS

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“…LncRNAs are non-coding RNA transcripts that constitute more than 200 nucleotides and regulate target gene expression via cis- or transregulation. [ 93 ]. It has been reported that the overexpression of lncRNA AK077216 during osteoclastogenesis promotes osteoclast differentiation and bone resorption by suppressing NIP45 and promoting NFATc1 expression [ 94 ].…”

Section: The Role Of Molecules In Osteoclast Regulationmentioning

confidence: 99%

“…CircRNA regulates cellular transcription, posttranslational expression, by interacting with miRNAs. CircRNAs are directly involved in bone-related signal transduction, forming a circRNA-miRNA-mRNA axis to work in bone remodeling [ 93 , 100 ]. During RANKL + CSF1-induced BMM differentiation to osteoclast, circRNA_28313 level was elevated.…”

Section: The Role Of Molecules In Osteoclast Regulationmentioning

confidence: 99%

Role of Biomolecules in Osteoclasts and Their Therapeutic Potential for Osteoporosis

Zhao

Patil

et al. 2021

Biomolecules

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Osteoclasts (OCs) are important cells that are involved in the regulation of bone metabolism and are mainly responsible for coordinating bone resorption with bone formation to regulate bone remodeling. The imbalance between bone resorption and formation significantly affects bone metabolism. When the activity of osteoclasts exceeds the osteoblasts, it results in a condition called osteoporosis, which is characterized by reduced bone microarchitecture, decreased bone mass, and increased occurrences of fracture. Molecules, including transcription factors, proteins, hormones, nucleic acids, such as non-coding RNAs, play an important role in osteoclast proliferation, differentiation, and function. In this review, we have highlighted the role of these molecules in osteoclasts regulation and osteoporosis. The developed therapeutics targeting these molecules for the treatment of osteoporosis in recent years have also been discussed with challenges faced in clinical application.

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“…And it is excluded repeated parts of previous reports, [123][124][125] such as DANCR, 126 ORLNC1 127 and XIST. 128 Researchers have systematically summarized these lncRNAs.…”

Section: The Role Of Lncrnas In Osteoclastogenesismentioning

confidence: 99%

LncRNAs as a new regulator of chronic musculoskeletal disorder

et al. 2021

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Musculoskeletal disorders are a group of conditions that affect the motor system, including bones, muscles, tendons, ligaments and joints. 1 People with multiple disorders are particularly vulnerable, especially in the context of an ageing population. Musculoskeletal disorders include a variety of conditions such as osteoarthritis (OA), rheumatoid arthritis (RA), osteopenia, osteoporosis, fractures, sarcopenia, etc. 2 Non-protein-coding RNA makes up 98% of the whole human genome. 3,4 These functional RNAs can be divided into two groups according to the threshold of 200 nucleotides (NTS): small and long non-coding RNAs (lncRNAs). 5,6 LncRNAs regulate the activities of both nearby and distant genes by multiple mechanisms. It could act as a scaffold for transcription factors and other molecules involved in transcription initiation. 7 Moreover, it could serve as protein and microRNA decoys to interfere with cell division by regulating a series of key genes. 8 For those mainly located in the cytoplasm, it could directly target mRNA and induce translation. 9 Currently, an increased number of lncRNAs are found to be involved in the regulation of development and homeostasis of skeletal muscle system. 10,11 It is notable that lncRNAs take key roles in musculoskeletal disorders.

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Role of LncRNAs and CircRNAs in Bone Metabolism and Osteoporosis

Cited by 37 publications

References 129 publications

The Development of Molecular Biology of Osteoporosis

The Development of Molecular Biology of Osteoporosis

Role of Biomolecules in Osteoclasts and Their Therapeutic Potential for Osteoporosis

LncRNAs as a new regulator of chronic musculoskeletal disorder

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