Role of liquid crystal in the emulsification of a gel emulsion with high internal phase fraction

Liu, Yihan; Friberg, Stig E.

doi:10.1016/j.jcis.2009.08.038

Cited by 25 publications

(14 citation statements)

References 37 publications

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“…The LLCs are anisotropic, and thus their formation can be ensured by observing them for their birefringence in crossed polarized light microscopy (CPLM) or small-angle X-ray scattering (SAXS). 25 …”

Section: Formulation Of Llcsmentioning

confidence: 99%

Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals

Rajabalaya

Musa

Kifli

et al. 2017

DDDT

105

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Liquid crystal (LC) dosage forms, particularly those using lipid-based lyotropic LCs (LLCs), have generated considerable interest as potential drug delivery systems. LCs have the physical properties of liquids but retain some of the structural characteristics of crystalline solids. They are compatible with hydrophobic and hydrophilic compounds of many different classes and can protect even biologicals and nucleic acids from degradation. This review, focused on research conducted over the past 5 years, discusses the structural evaluation of LCs and their effects in drug formulations. The structural classification of LLCs into lamellar, hexagonal and micellar cubic phases is described. The structures of these phases are influenced by the addition of surfactants, which include a variety of nontoxic, biodegradable lipids; these also enhance drug solubility. LLC structure influences drug localization, particle size and viscosity, which, in turn, determine drug delivery properties. Through several specific examples, we describe the applications of LLCs in oral and topical drug formulations, the latter including transdermal and ocular delivery. In oral LLC formulations, micelle compositions and the resulting LLC structures can determine drug solubilization and stability as well as intestinal transport and absorption. Similarly, in topical LLC formulations, composition can influence whether the drug is retained in the skin or delivered transdermally. Owing to their enhancement of drug stability and promotion of controlled drug delivery, LLCs are becoming increasingly popular in pharmaceutical formulations.

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Section: Formulation Of Llcsmentioning

confidence: 99%

Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals

Rajabalaya

Musa

Kifli

et al. 2017

DDDT

105

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“…Other key variables affecting the final emulsion morphology are: i) oil type [72], ii) surfactant type [72], iii) surfactant to oil ratio [72,79,83], iv) initial surfactant location [72], and v) water to oil ratio [84]. Peculiar phase inversion pathways can be optimized in order to obtain microemulsions, nanoemulsions and bicontinuous emulsions with desired features [26,63,79,82,[85][86][87][88][89][90][91][92].…”

Section: Phase Behavior and Its Role In Phase Inversionmentioning

confidence: 99%

Phase inversion emulsification: Current understanding and applications

Perazzo

Preziosi

Guido

2015

Advances in Colloid and Interface Science

204

121

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“…Liu and Friberg, in a recent article (Liu et al, 2009), discussed the formation of an intermediary double emulsion during phase inversion from water in oil emulsion (Inversed micelles of Tween®80 in silicon oil) to oil in water emulsion with high internal phase fraction, accompanied by a lamellar liquid crystal phase. The explanation is that this liquid crystalline phase is able to increase the double emulsion droplet stability, being part of the inversion process.…”

Section: Resultsmentioning

confidence: 99%

Attainment of hydrogel-thickened nanoemulsions with tea tree oil (Melaleuca alternifolia) and retinyl palmitate

Juliana¹,

Tatiana²,

Mezadri³

et al. 2011

Afr. J. Biotechnol.

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We propose the development of hydrogel-thickned nanoemulsions (HTNs) with tea tree essential oil (Melaleuca alternifolia) and vitamin A palmitate (retinyl palmitate). Nanoemulsions and HTNs were produced by the use of phase inversion method, employing non-ionic surfactants. As surfactant phase were used sorbitan esters and hydrogenated/ethoxylated castor oil. HTNs with drops size ranging between 86 to 96 nm were obtained, depending on the polymer used, with increased viscosity. Rheological profile of developed HTNs was determined, showing the influence of the kind of polymer used, here all presented pseudo-plastic behaviour, with different viscosity measurement.

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Role of liquid crystal in the emulsification of a gel emulsion with high internal phase fraction

Cited by 25 publications

References 37 publications

Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals

Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals

Phase inversion emulsification: Current understanding and applications

Attainment of hydrogel-thickened nanoemulsions with tea tree oil (Melaleuca alternifolia) and retinyl palmitate

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