Role of leukemia inhibitory factor in the nervous system and its pathology

Ostasov, Pavel; Houdek, Zbyněk; Cendelín, Jan; Králíčková, Milena

doi:10.1515/revneuro-2014-0086

Cited by 13 publications

(12 citation statements)

References 64 publications

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“…Indeed, we have observed not only the growth of the number of nerve fibers in the distal segment of the injured sciatic nerve, but also the improvement of the structure of the regenerative neuroma. In mice with the nerve injury receiving rhLIF, positive changes in the structure of the damaged nerve can be attributed to the effect of cytokine on axons of neurons, expression of NGF, and anti-apoptotic effect on nerve cells [11,12]. We do not exclude that these mice also have positive changes in the functioning of the motor neurons of the spinal cord.…”

Section: Activity Of Oxidative Stress and Antioxidant Defense Factorsmentioning

confidence: 95%

“…However, in this work, we have used long-term subcutaneous injection of rhLIF in the area of the sciatic nerve injury [16]. Such an approach can contribute to the maintenance of a sufficiently stable cytokine content at the site of the injury, which, according to Ostasov [11], is important for the development of regenerative processes in it. Indeed, we have observed not only the growth of the number of nerve fibers in the distal segment of the injured sciatic nerve, but also the improvement of the structure of the regenerative neuroma.…”

Section: Activity Of Oxidative Stress and Antioxidant Defense Factorsmentioning

confidence: 99%

“…As Petrova notes [3], the efficiency of the sciatic nerve regeneration after injury largely depends on the state of the motor neurons of the spinal cord. In the model of spinal cord injury, it has been shown that in this organ LIF enhances the proliferation of NSCs and promotes their predominant differentiation into neuronal direction, improves the survival of the generated and functioning motor neurons, and stimulates the growth of neurites [11,24,25]. It has been established that in the motor neurons of the spinal cord there is LIF receptor (LIFR), and knockout mice (LIFR -/-) exhibit 40 % reduction of motor neurons [11].…”

Section: Activity Of Oxidative Stress and Antioxidant Defense Factorsmentioning

confidence: 99%

“…In the model of spinal cord injury, it has been shown that in this organ LIF enhances the proliferation of NSCs and promotes their predominant differentiation into neuronal direction, improves the survival of the generated and functioning motor neurons, and stimulates the growth of neurites [11,24,25]. It has been established that in the motor neurons of the spinal cord there is LIF receptor (LIFR), and knockout mice (LIFR -/-) exhibit 40 % reduction of motor neurons [11]. The possibility of LIF retrograde transport, like NGF, from nerve terminals to the bodies of sensory neurons in the spinal ganglia as a survival factor is proved [12].…”

Section: Activity Of Oxidative Stress and Antioxidant Defense Factorsmentioning

confidence: 99%

“…Among the variety of cellular factors with a stimulating effect on reparative regeneration of peripheral nerves, our attention was attracted by the leukemia inhibitory factor (LIF) from the family of interleukin-6 (IL-6), which exhibits properties not only of the polyfunctional cytokine, but also of the neurotrophic factor [11,12]. In particular, it has been established that LIF prevents demyelization, is a growth factor for neural stem cells (NSCs), Schwann cells and axons, reduces their apoptosis, increases the lifetime of motor neurons.…”

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confidence: 99%

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Effect of exogenous leukemia inhibitory factor on reparative regeneration of the peripheral nerve in mice

Labunets¹,

Demydchuk²,

M³

et al. 2017

JCOT

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The role of trophic and growth factors in the regeneration of the damaged peripheral nerve is known. The leukemia inhibitory factor (LIF) exhibits properties not only of the polyfunctional cytokine, but also the neurotrophic factor. Regeneration of the peripheral nerve is impaired during oxidative stress in the area of injury.The purpose of the work was to investigate the effect of recombinant human LIF (rhLIF) on the efficacy of reparative regeneration of the sciatic nerve.Materials and methods. Adult male FVB/N mice were divided into the following groups: sham-operated; trauma (neurotomy) of the right sciatic nerve; nerve injury and subcutaneous injection of rhLIF at a dose of 1 μg per animal daily from the third day after the nerve injury. The study was conducted 4 weeks after the injury. At morphometry, the density of nerve fibers in distal nerve segments after impregnation with nitric oxide silver was evaluated. The motor function was evaluated in the “open field” test by the number of crossed squares, and in footprint test by the distance between the extreme toes of the right foot. In the area of muscle injury, the content of malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase was estimated.Results. The total number of nerve fibers in the distal segment of the nerve of mice with trauma and injection of rhLIF is greater (p < 0.05) than in mice with only nerve injury and does not differ from sham-operated animals. Horizontal motor activity in mice with nerve injury is lower (p <0.05) than in sham-operated and cytokine injected mice. The distance between the extreme toes of the sham-operated mice is greater (p < 0.05) than in mice with nerve injury, as well as injuries and injections of rhLIF, but after the injection of cytokine, the rates are higher (p < 0.05) than in the group of mice without it. After the injury, the content of malondialdehyde and catalase activity increases in muscle tissue, while the activity of glutathione reductase decreases (p < 0.05). Under the influence of rhLIF, the parameters change to the values of sham-operated mice, and, in addition, the activity of the glutathione peroxidase is significantly increased.Conclusions. Injection of rhLIF to mice with a sciatic nerve injury promotes a more complete restoration of the structural organization of the damaged nerve and improves the motor function of the injured limb. At the same time, the balance between the factors of oxidative stress and antioxidant system is improved in the muscle tissue in the area of the nerve injury.

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Section: Activity Of Oxidative Stress and Antioxidant Defense Factorsmentioning

confidence: 95%

Section: Activity Of Oxidative Stress and Antioxidant Defense Factorsmentioning

confidence: 99%

Section: Activity Of Oxidative Stress and Antioxidant Defense Factorsmentioning

confidence: 99%

Section: Activity Of Oxidative Stress and Antioxidant Defense Factorsmentioning

confidence: 99%

mentioning

confidence: 99%

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Effect of exogenous leukemia inhibitory factor on reparative regeneration of the peripheral nerve in mice

Labunets¹,

Demydchuk²,

M³

et al. 2017

JCOT

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Myokines mediate the cross talk between skeletal muscle and other organs

Chen

Wang

You

et al. 2020

Journal Cellular Physiology

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Myokines are muscle‐derived cytokines and chemokines that act extensively on organs and exert beneficial metabolic functions in the whole‐body through specific signal networks. Myokines as mediators provide the conceptual basis for a whole new paradigm useful for understanding how skeletal muscle communicates with other organs. In this review, we summarize and discuss classes of myokines and their physiological functions in mediating the regulatory roles of skeletal muscle on other organs and the regulation of the whole‐body energy metabolism. We review the mechanisms involved in the interaction between skeletal muscle and nonmuscle organs through myokines. Moreover, we clarify the connection between exercise, myokines and disease development, which may contribute to the understanding of a potential mechanism by which physical inactivity affects the process of metabolic diseases via myokines. Based on the current findings, myokines are important factors that mediate the effect of skeletal muscle on other organ functions and whole‐body metabolism.

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Neuronal Src homology 2 B adaptor protein 1 and brain growth

Rui

2021

Factors Affecting Neurodevelopment

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Role of leukemia inhibitory factor in the nervous system and its pathology

Cited by 13 publications

References 64 publications

Effect of exogenous leukemia inhibitory factor on reparative regeneration of the peripheral nerve in mice

Effect of exogenous leukemia inhibitory factor on reparative regeneration of the peripheral nerve in mice

Myokines mediate the cross talk between skeletal muscle and other organs

Neuronal Src homology 2 B adaptor protein 1 and brain growth

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