Role of Ketotifen on metabolic profiles, inflammation and oxidative stress in diabetic rats

Abstract

Abstract. We aim to explore effects of Ketotifen on metabolic profiles, inflammation and oxidative stress. Sprague Dawley (SD) male rats were randomly divided into normal control group (NC) and experimental groups, and experimental group rats were fed with high-sugar and fat diet for 6 weeks. Then, experimental group rats were divided into diabetes group (DM) and ketotifen treatment group (KT). KT group was given ketotifen via Intragastric for 8 weeks with the dosage of 0.09 mg/kg/d. Fasting plasma glucose (FPG) was measured using glucose oxidase-phenol amino phenazone method. Fasting insulin (FINS), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were tested by enzyme-linked immunosorbent assay. Malondialdehyde (MDA) and superoxide dismutase (SOD) were quantified by spectrophotometer method. Before Ketotifen administration, compared with NC group, DM and KT groups showed significantly high levels of body weight,

Calming Down Mast Cells with Ketotifen: A Potential Strategy for Multiple Sclerosis Therapy?

“…Considering the pathological potential of these mediators [42][43][44], we presumed that mast cell stabilizers could be useful for therapeutic interventions. Ketotifen fumarate (Ket) is a strong mast cell stabilizer [45] and a first-generation antihistamine drug widely employed to treat some allergic diseases [46,47] and other inflammatory pathologies such as gout, diabetes, thyroiditis and uveitis [48][49][50][51][52][53]. Given this background, we assumed that this drug could be potentially therapeutic in MS.…”

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“…[11] HDL and SOD levels dramatically increased, while the Ketotifen group's levels declined more noticeably. [12] Maltitol boosted glucose uptake in isolated rat muscle and decreased glucose absorption in isolated rat jejunum when insulin was present but not the other way around. [13] Post-transplantation diabetes can be reversed or at least improved by switching from tacrolimus to cyclosporine, which is a straightforward, safe, and effective treatment.…”