Role of K vitamins in the regulation of tissue calcification

Vermeer, Cees; Braam, Lavienja A. J. L. M.

doi:10.1007/s007740170021

Cited by 56 publications

(53 citation statements)

References 45 publications

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“…To our knowledge, there are no published data specifically focused on phylloquinone intake and risk of CHD from cohort studies. Phylloquinone has a potential role in bone formation (Ferland, 1998) and calcification of the vessel walls (Jie et al, 1995;Vermeer & Braam, 2001). The vitamin Kdependent protein, matrix Gla protein (MGP) has been identified in atherosclerotic plaques (Dhore et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…The vitamin Kdependent protein, matrix Gla protein (MGP) has been identified in atherosclerotic plaques (Dhore et al, 2001). It has been hypothesized that vitamin K deficiency could lead to synthesis of undercarboxylated MGP, which can no longer function in inhibiting tissue calcification, thus increasing the risk of vascular calcification (Vermeer & Braam, 2001). Jie et al have reported in a population-based study of postmenopausal women that those with calcified lesions had lower intakes of phylloquinone and impaired vitamin K status than those without lesions (Jie et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

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Phylloquinone intake as a marker for coronary heart disease risk but not stroke in women

Erkkilä

Booth

et al. 2004

Eur J Clin Nutr

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Objective: To examine the feasibility of using phylloquinone intake as a marker for coronary heart disease (CHD) and stroke risk in women. Design and setting: Nurses' Health Study, a prospective cohort study during 1984-2000 . Dietary data were collected in 1984, 1986 , 1990, and 1994 using a validated semiquantitative food frequency questionnaire. Subjects: A total of 72 874 female nurses, aged 38-65 y, without previously diagnosed angina, myocardial infarction (MI), stroke, or cancer at baseline. Main outcome measures: Incidence of nonfatal MI, CHD deaths, total CHD events, ischemic, and total strokes. Results: There were 1679 CHD events (1201 nonfatal) and 1009 strokes (567 ischemic). After adjustment for age and lifestyle factors associated with cardiovascular disease risk, the multivariate relative risks (RR) (95% CI) of total CHD from the lowest to the highest quintile category of phylloquinone intake were 1 (reference), 0.80 (0.69-0.94), 0.86 (0.74-1.00), 0.77 (0.66-0.99), and 0.79 (0.68-0.92), P for trend ¼ 0.01. Further adjustment for dietary intakes of saturated fat, polyunsaturated fat, trans fatty acids, eicosapentaenoic, and docosahexaenoic acids, cereal fiber, and folate attenuated the association (RR comparing extreme quintiles 0.84 [0.71-1.00], P for trend ¼ 0.12). Incidence rates of total or ischemic strokes were not associated with phylloquinone intake. Conclusion: The data suggest that high phylloquinone intake may be a marker for low CHD risk. Dietary and lifestyle patterns associated with phylloquinone intakes, rather than intake of the nutrient itself, might account for all or part of the weak association. Sponsorship:

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Phylloquinone intake as a marker for coronary heart disease risk but not stroke in women

Erkkilä

Booth

et al. 2004

Eur J Clin Nutr

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“…Vitamin K promotes post-translational conversion of protein glutamate residues in osteocalcin into gamma-carboxy glutamate (Gla) [11,12], which is secreted by the osteoblasts. Vitamin K deficiency will cause production of under-carboxylated osteocalcin (ucOC) [13], and ucOC levels are therefore considered to be a sensitive measure of vitamin K status [14].…”

Section: Introductionmentioning

confidence: 99%

Vitamin K2 supplementation does not influence bone loss in early menopausal women: a randomised double-blind placebo-controlled trial

et al. 2009

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“…Białka te noszą nazwę białek Gla. Należą do nich białka układu krzepnięcia, a także osteokalcyna i osteopontyna [1][2][3][4].…”

Section: Wstępunclassified

Undercarboxylated Osteocalcin as an Indirect Marker of Vitamin K Status in Girls in Various Pubertal Stages

Kulik-Rechberger¹,

Szponar²,

Kościesza³

2013

Pediatr. Endocrinol.

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Kulik-Rechberger B. i inni: Nieukarboksylowana postać osteokalcyny jako pośredni wskaźnik zaopatrzenia w witaminę K dziewcząt w różnych stadiach pokwitaniaVol. 12/2013 Nr 1(42) Endokrynologia PediatrycznaPediatric Endocrinology STRESZCZENIE/ABSTRACTWstęp. Witamina K bierze udział w γ-karboksylacji reszt glutaminowych (Glu) osteokalcyny. W postaci nieukarboksylowanej osteokalcyna nie ma dostatecznej zdolności do wiązania wapnia w kryształach hydroksyapatytu, zewną-trzkomórkowej macierzy kostnej. Uważa się, że stężenie nieukarboksylowanej osteokalcyny (ucOC) odzwierciedla stężenie witaminy K we krwi. Celem niniejszej pracy jest określenie stężenia osteokalcyny i ucOC w surowicy dziewcząt w różnych stadiach pokwitania. Materiał i metody. Badaniami objęto 133 zdrowe dziewczęta w wieku od 11,8 do 13,7 lat, których rozwój oceniano dwukrotnie w odstępie 6 miesięcy. Określano tempa wzrastania i nasilenie procesu kościotworzenia, mierząc stężenie N-końcowego propeptydu prokolagenu typu I (PINP) w surowicy. Wyniki. Dziewczęta przed menarche (w II i III stadium pokwitania) miały istotnie wyższe średnie przyrosty wysokości ciała i średnie stężenie PINP niż dziewczęta po menarche (stadium IV). Stężenie osteokalcyny w surowicy było wyższe u dziewcząt w stadium II niż u dziewcząt w stadium IV, ale stężenie ucOC nie różniło się między grupami. Podobny był też %ucOC. Wnioski. Stężenie nieukarboksylowanej osteokalcyny w surowicy, w odróżnieniu od stężenia osteokalcyny, nie zależy od stadium pokwitania dziewcząt. Stężenia ucOC jak też %ucOC nie wskazują na niedobór witaminy K u badanych dziewcząt. Endokrynol. Ped. 12/2013;1(42):37-44.Introduction. Vitamin K is involved in the γ-carboxylation of certain glutamate residues (Glu) of osteocalcin. In undercarboxylated form osteocalcin does not have sufficient capacity to bind calcium to hydroxyapatite crystals of extaracellular matrix. Undercarboxylated osteocalcin (ucOC) concentration in blood is considered to be a sensitive measure of vitamin K status. The aim of this study is the assessment of serum concentration of osteocalcin and ucOC in girls in various pubertal stages. Materials and methods. The study was performed on 133 healthy girls (age range: 11.8-13.7 years) who were examined twice in 6 month intervals. Growth velocity and intensity of bone formation,

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Role of K vitamins in the regulation of tissue calcification

Cited by 56 publications

References 45 publications

Phylloquinone intake as a marker for coronary heart disease risk but not stroke in women

Phylloquinone intake as a marker for coronary heart disease risk but not stroke in women

Vitamin K2 supplementation does not influence bone loss in early menopausal women: a randomised double-blind placebo-controlled trial

Undercarboxylated Osteocalcin as an Indirect Marker of Vitamin K Status in Girls in Various Pubertal Stages

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