Role of Jumpstart Nutrition®, a Dietary Supplement, to Ameliorate Calcium-to-Phosphorus Ratio and Parathyroid Hormone of Patients with Osteoarthritis

Abstract

The aim of this study was to use Jumpstart Nutrition® bone supplementing combination with vitamin-K2 and coenzyme-Q10 characterized by an innovative delivery system that improves bioavailability of calcium-to-phosphorus ratio (CPR) and parathyroid hormone (PTH) in the management of osteoarthritis (OA). This eight-week registry included 108 patients treated for symptomatic OA confirmed with radiological images. On top of that, 63 patients used Jumpstart Nutrition® supplement, mainly prepared with calcium, phosphorus, coenzyme-Q10, vitamin-K2, vitamin-D2, vitamin-C, folic acid, curcumin and boswellic acids. Rescue medication was also recommended. Patients’ pain and functional capacity through outcome measures—knee-injury osteoarthritis outcome scale (KOOS) and Karnofsky performance scale (KPS), biomarkers such as levels of CPR, PTH and 25-hydroxy-vitamin-D were evaluated for the groups with and without supplement using appropriate kits. After eight weeks, the levels of CPR and PTH were all significantly improved (p < 0.001), fewer subjects had to use rescue medication (p < 0.05) and variation of pain and functional capacity under KOOS and KPS (p < 0.05) of the patients in the supplement group compared to controls. This registry study indicates that Jumpstart Nutrition® can be used safely for effective management of OA patients for the amelioration of CPR, PTH and functional activities confirmed with biomarkers and radiological images correlated with the Kellgren-Lawrance scale.

Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death

“…There is no cure; however, analgesic and anti-inflammatory medicines, such as corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs) are available [31][32][33]. Several studies have shown that CoQ10 slows OA progression [17,18,22]. Although anti-oxidant and anti-inflammatory effects of CoQ10 have been reported [34][35][36][37][38], little is known about the effects of micellized-…”

“…One clinical study found that OA patients exhibited low levels of CoQ10 and that the extent of oxidative stress was negatively correlated with the CoQ10 level [17]. Supplementation with a combination of vitamin-K 2 and CoQ10 improved pain, stiffness, and the daily performance of OA patients [18]. Several studies have reported therapeutic effects of CoQ10 in patients with inflammatory disorders [19][20][21].…”

Exploring the Biomarker of Collagen Degradation in Cartilage for Osteoarthritis Management: The Power of Topical Phytotherapy

“…Seventy-two cohorts (62.5% of females) have been assigned to the experimental group (TPT) out of the remaining 144 patients with KOA who have significant pain syndromes, discomfort, obesity (both general and central), cartilage damage, subchondral bone changes, osteophyte formation, muscle weakness, oxidative stress, and inflammation of the synovium tissue as evidenced by elevated levels of biomarkers: interleukin-10 (IL-10), Tumours necrosis factor-alpha (TNF-alpha), malondialdehyde (MDA), creatine kinasemuscle (CK-MM), aldolase-A, and 4hydroxyproline levels, and radiological images, and the other 72 subjects (56.9% of females) have been assigned to the control group treated with nutraceutical supplements (NS group). Following the prior methodology, each individual completed a baseline questionnaire for demographic information [19][20].…”

“…Observation of the patient's perceived symptoms of pain intensity in the last 24 hrs. for pain, stiffness, and functional disability of the individual patient, the patient's opinion about their knee and associated problems under VAS, WOMAC, KOOS, and LEFS, and anthropometric parameters (BMI, WC, HC, WHpR, and WHtR) as per previous study [15][16][17][18][19] for experimental and control groups at 0-week and 12-week. The significance of all the parameters of the COM and AP at 12 weeks was evaluated with the help of ROC curve analysis, metaanalysis, and radar chart and graphically depicted.…”

“…The main common phenomena in OA are the pain syndrome, as well as the psychometric quality of life, which leads to an oxidative stress factor that indicates the disease progression [1]. As a result, appropriate pain parameters should be wellthought-out under internationally accepted clinical outcome measures, such as the visual analogue scale (VAS) [15], the Western Ontario and McMaster Universities osteoarthritis index (WOMAC index) [16], the Knee-Injury Osteoarthritis Outcomes Scale (KOOS) [17], and the Lower Extremity Functional Scale (LEFS) [18], as well as anthropometric factors, such as body weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-height ratio (WHtR), and waist-to-hip ratio (WHpR) which contribute another major causing factor of pain and disability [19] This degenerative disease is characterized by biochemical composition and structural changes that alter the tissue's biological and biomechanical functions. The biological changes include the loss of matrix proteins, such as proteoglycan and collagen, an increase in macroscopic degenerative fibrillation, and altered water content.…”