Role of ischemic preconditioning and the portosystemic shunt in the prevention of liver and lung damage after rat liver transplantation1

Fernández, Leticia; Heredia, Nicolás; Peralta, Carmen; Xaus, Carme; Roselló‐Catafau, Joan; Rimola, Antoni; Marco, Alberto; Serafín, Anna; Deulofeu, R.; Gelpí, E.; Grande, Luís

doi:10.1097/01.tp.0000067529.82245.4e

Cited by 29 publications

(20 citation statements)

References 47 publications

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“…This could prevent the deleterious effects of TNF on the liver and promote liver regeneration following ROLT. Indeed, the reduction in TNF release following hepatic I/R induced by ischemic preconditioning has been previously reported in normothermic and cold ischemia conditions without hepatectomy (28)(29)(30). However, in our hands, ischemic preconditioning did not modify the levels of either IL-6 or TNF in reduced-size liver grafts after transplantation.…”

Section: Discussioncontrasting

confidence: 45%

“…The use of ischemic preconditioning in reduced-size liver transplantation should be considered, as Clavien et al reported the first clinical application of ischemic preconditioning during normothermic ischemia associated with hepatic resections (26). In addition, results of experimental hepatic ischemia without liver resection suggest that ischemic preconditioning could modulate the negative effects of I/R on hepatic regeneration (24,(27)(28)(29)(30). Thus, ischemic preconditioning protects Table 1: Flow chart of the interventions and measurements corresponding to protocols 1, 2, 3 and 4.…”

Section: Introductionmentioning

confidence: 99%

“…HGF, hepatocyte growth factor; MDA, malondialdehyde; LPO, lipid hydroperoxides; H 2 O 2 , hydrogen peroxide; PCNA, proliferating cell nuclear antigen; IL-6, interleukin-6; TNF-a, tumor necrosis factor-a; XDH/XOD, xanthine dehydrogenase/xanthine oxidase against the deleterious effect of ischemia on ATP degradation in experimental models of warm ischemia (24,27). In addition, this surgical strategy, through nitric oxide (NO), protects against the deleterious effects of both ROS and TNF on hepatic I/R injury (28)(29)(30).…”

Section: Introductionmentioning

confidence: 99%

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Protection of Reduced-Size Liver for Transplantation

Franco-Gou¹,

Peralta²,

Massip-Salcedo

et al. 2004

American Journal of Transplantation

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The shortage of available organs for liver transplantation has motivated the development of new surgical techniques such as reduced-size liver transplantation. Ischemia-reperfusion (I/R) associated with liver transplantation impairs liver regeneration. Ischemic preconditioning is effective against I/R injury in clinical practice of liver tumour resections. The present study evaluated the effect of ischemic preconditioning on reduced-size liver for transplantation and attempted to identify the underlying protective mechanisms. Hepatic injury and regeneration (transaminases, proliferating cell nuclear antigen [PCNA] labeling index, and hepatocyte growth factor [HGF]) were assessed after reduced-size orthotopic liver transplantation (ROLT). Energy metabolism, oxidative stress, tumor necrosis factor-a (TNF) and interleukin-6 (IL-6) were examined as possible mechanisms involved in liver regeneration. Ischemic preconditioning reduced transaminase levels and increased HGF levels and the percentage of PCNApositive hepatocytes after ROLT. This was associated with a decrease in oxidative stress following ROLT, whereas energy metabolism and hepatic IL-6 and TNF release were unchanged. The benefits of ischemic preconditioning on hepatic injury and liver regeneration could be mediated, at least partially by nitric oxide. These results suggest a new potential application of ischemic preconditioning in reduced-size liver transplantation.

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Section: Discussioncontrasting

confidence: 45%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Protection of Reduced-Size Liver for Transplantation

Franco-Gou¹,

Peralta²,

Massip-Salcedo

et al. 2004

American Journal of Transplantation

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“…İskemik önkoşullamanın olumlu etkilerinin gözlendi-ği diğer en önemli organ karaciğerdir. Yapılan çalış-malarda, ısı şok ile oluşturulan önkoşullama sayesinde iskemiye karşı hepatik korunma sağlanmıştır (24) . Ortotopik karaciğer transplantasyonlarında hepatik önkoşullamanın büyük önem taşıdığı bir gerçektir (24) .…”

Section: Mi̇yokard Dişi Doku Ve Organlarda İskemi̇k öNkoşullamaunclassified

Clinical Importance of Ischemic Preconditioning

Oncel¹,

Dinçer²,

Cinel³

2012

GKDA Derg

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“…Tsuyama et al [133] reported that IPC prolonged survival, suppressed liver necrosis induced by IRI and inhibited the release of TNF-α at 1 h, and IL-6 at 2 and 5 h of the reperfusion phase in mice. IPC has also been shown to reduce TNF-α production in normothermic and cold ischaemic conditions [125,134,135] . In contrast, Bedirli and others demonstrated that IPC inhibited the production of TNF-α, but not IL-6 during the late (24 and 48 h) phases of reperfusion in rats following partial hepatectomy [136] .…”

Section: Up-regulation Of the Regenerative Cytokine Network Tumour Nementioning

confidence: 99%

Role of ischaemic preconditioning in liver regeneration following major liver resection and transplantation

Gomez¹

2007

WJG

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Liver ischaemic preconditioning (IPC) is known to protect the liver from the detrimental effects of ischaemicreperfusion injury (IRI), which contributes significantly to the morbidity and mortality following major liver surgery. Recent studies have focused on the role of IPC in liver regeneration, the precise mechanism of which are not completely understood. This review discusses the current understanding of the mechanism of liver regeneration and the role of IPC in this setting. Relevant articles were reviewed from the published literature using the Medline database. The search was performed using the keywords "liver", "ischaemic reperfusion", "ischaemic preconditioning", "regeneration", "hepatectomy" and "transplantation". The underlying mechanism of liver regeneration is a complex process involving the interaction of cytokines, growth factors and the metabolic demand of the liver. IPC, through various mediators, promotes liver regeneration by up-regulating growthpromoting factors and suppresses growth-inhibiting factors as well as damaging stresses. The increased understanding of the cellular mechanisms involved in IPC will enable the development of alternative treatment modalities aimed at promoting liver regeneration following major liver resection and transplantation.

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Role of ischemic preconditioning and the portosystemic shunt in the prevention of liver and lung damage after rat liver transplantation1

Abstract: These findings indicate that ischemic preconditioning could be a preferred treatment to reduce hepatic and pulmonary damage associated with liver transplantation. However, this strategy may not be effective in several clinical situations requiring a portosystemic shunt.

Cited by 29 publications

References 47 publications

Protection of Reduced-Size Liver for Transplantation

Protection of Reduced-Size Liver for Transplantation

Clinical Importance of Ischemic Preconditioning

Role of ischaemic preconditioning in liver regeneration following major liver resection and transplantation

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