Role of “Ischemia Modified Albumin” (IMA) in acute coronary syndromes

Reddy, Chirra Bhakthavatsala; Cyriac, Cijo; Desle, Hrishikesh B.

doi:10.1016/j.ihj.2014.12.005

Cited by 45 publications

(23 citation statements)

References 22 publications

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“…Hypoxia causing ischaemic damage in both testes due to changes in the testis venous drainage system has been found in patients with a varicocele (Gat, Zukerman, Chakraborty, & Gornish, 2005). IMA has been shown to increase in patients with ischaemic conditions such as acute coronary syndrome, stroke and chronic liver disease (Abboud et al, 2007;Cakir et al, 2012;Reddy, Cyriac, & Desle, 2014). IMA levels were similarly increased and albumin levels decreased in our study (Figure 3).…”

Section: Discussionsupporting

confidence: 75%

Thiol–disulphide balance in infertility secondary to varicocele

et al. 2019

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Oxidative stress plays an important role in the development of infertility secondary to varicocele. We aimed to investigate the dynamic thiol–disulphide homeostasis as an oxidative stress marker in the spermatic vein of infertility secondary to varicocele. Sixty‐one patients with varicocele were included in the study. Blood was drawn from the median cubital vein and the testicular venous return side before the spermatic vein was separated during surgery. Total thiol, native thiol, disulphide, ischaemia modified albumin (IMA) and albumin values were measured from both the dilated spermatic vein and the median cubital vein. The disulphide/native thiol, disulphide/total thiol and native thiol/total thiol ratios were determined. The mean age of the patients was 27.0 ± 6.68 (15–50) years. While the albumin, native thiol and total thiol values and the native thiol/total thiol ratio were significantly lower (p = 0.004, p < 0.001, p < 0.001, p < 0.001 respectively), the IMA value and the disulphide/native thiol and disulphide/total thiol ratios were significantly higher (p < 0.001, p < 0.001, p < 0.001 respectively) in the samples taken from spermatic venous blood. Thiol–disulphide balance had deteriorated towards disulphide formation in the spermatic vein compared with the peripheral vein. Abnormal thiol–disulphide balance may be an independent risk factor for infertility secondary to varicocele.

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Section: Discussionsupporting

confidence: 75%

Thiol–disulphide balance in infertility secondary to varicocele

et al. 2019

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“…IMA is one of the new markers that was investigated in patients with CO poisoning. Previous studies have shown that IMA levels can increase in many ischemic diseases such as pulmonary embolism, acute mesenteric ischemia, deep venous thrombosis, acute coronary syndromes, ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, and seizure [9–15]. To our knowledge, in the English literature, there are two studies that evaluated the relationship of CO poisoning and IMA levels.…”

Section: Discussionmentioning

confidence: 99%

Ischemia‐modified albumin levels in the prediction of acute critical neurological findings in carbon monoxide poisoning

Daş¹,

Çevik²,

Erel

et al. 2016

The Kaohsiung J of Med Scie

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The aim of the study was to determine whether serum ischemia-modified albumin (IMA) levels in patients with carbon monoxide (CO) poisoning were higher compared with a control group of healthy volunteers. In addition, the study sought to determine if there was a correlation between serum IMA levels and carboxyhemoglobin (COHB) levels and other critical neurological findings (CNFs). In this prospective study, the IMA levels of 100 patients with CO poisoning and 50 control individuals were compared. In addition, the IMA and COHB levels were analyzed according to absence or presence CNFs in patients with CO poisoning. The levels of IMA (mg/dL) on admittance, and during the 1(st) hour and 3(rd) hour, in patients with CO poisoning (49.90 ± 35.43, 30.21 ± 14.81, and 21.87 ± 6.03) were significantly higher, compared with the control individuals (17.30 ± 2.88). The levels of IMA in the 6(th) hour were not higher compared with control individuals. The levels of IMA on admittance, and during the 1(st) hour, 3(rd) hour, and 6(th) hour, and COHB (%) levels in patients who had CNFs were higher compared with IMA levels and COHB levels in patients who had no CNFs (p < 0.001). However, when the multivariate model was created, it was observed that IMA level on admittance was a poor indicator for prediction of CNFs (odds ratio = 1.05; 95% confidence interval, 1.01-1.08). We therefore concluded that serum IMA levels could be helpful in the diagnosis of CO poisoning. However, we believe that IMA levels cannot be used to predict which patients will develop CNFs due to CO poisoning.

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“…IMA is currently considered a new biomarker for myocardial ischemia that can be elevated in the early stages of irreversible necrosis of cardiomyocytes. Compared with other myocardial injury biochemicals in patients with acute coronary syndrome, Markers can be detected earlier and with higher sensitivity [ 8 , 9 ]. IMA levels also increase during myocardial ischemia-reperfusion injury, which is associated with oxidative stress induced by cardiac and extracardiac events.…”

Section: Introductionmentioning

confidence: 99%

Correlation between ischemia-modified albumin level and coronary collateral circulation

Chen

Tian

et al. 2020

BMC Cardiovasc Disord

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Objective: To investigate the correlation between ischemia-modified albumin (IMA) levels and coronary collateral circulation (CCC) in patients with chronic total occlusive (CTO). Methods: Coronary angiography was performed in the Department of Cardiology, Zhongnan Hospital of Wuhan University from 2017 to 08 to 2019-02 to identify 128 patients with CTO lesions in at least one major coronary artery. According to the Rentrop evaluation criteria, the degree of CCC formation was divided into the poor CCC formation group (Rentrop0-1 grade,n = 69) and the good CCC formation group (Rentrop2-3 grade,n = 59). The IMA level of the patients was measured using an albumin-cobalt binding assay. The general data, routine blood panel, total bilirubin (TBIL), blood lipids, uric acid (UA), left ventricular ejection fraction (LVEF) and other indicators of the patients were recorded and analyzed while assessing the patients' blood vessel occlusion. Results: The proportion of platelet count and diabetes in the poor CCC group was higher than that in the good CCC group (P < 0.05). The ratio of ischemia-modified albumin and total bilirubin in the poor CCC group was lower than that in the good CCC group (P < 0.05). Multivariate logistic regression analysis showed that ischemia-modified albumin was positively correlated with CCC formation [OR = 1.190,95% CI (1.092-1.297),P < 0.001], while diabetes was negatively correlated with CCC formation [OR = 0.285,95% CI (0.094-0.864), P < 0.05]. Ischemic modified albumin predicted good formation of CCC according to the ROC curve, and the area under the ROC curve was 0.769(95% CI,0.686-0.851, P<0.001); the optimal cutoff value was 63.35 KU/L, and the sensitivity was 71.2%, specificity is 71%. Conclusion: The IMA level is closely related to good formation of CCC. Higher IMA levels can be used as an effective predictor of good CCC formation in patients with CTO.

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Role of “Ischemia Modified Albumin” (IMA) in acute coronary syndromes

Abstract: In conclusion the benefit of the test would be to rule out ACS in patients who present early to ED with inconclusive diagnosis.

Cited by 45 publications

References 22 publications

Thiol–disulphide balance in infertility secondary to varicocele

Thiol–disulphide balance in infertility secondary to varicocele

Ischemia‐modified albumin levels in the prediction of acute critical neurological findings in carbon monoxide poisoning

Correlation between ischemia-modified albumin level and coronary collateral circulation

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