Role of iron in alcoholic liver disease: introduction and summary of the symposium

Purohit, Vishnudutt; Russo, Denise; Salin, Marvin L.

doi:10.1016/s0741-8329(03)00132-0

Cited by 45 publications

(26 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The chelating effect of tea polyphenol on iron is beneficial because the high level of stored iron is associated with an excess risk of lipid peroxidation, which is involved in the pathogenesis of liver steatosis [21]. Therefore, the depletion of iron storage by GTD could attenuate the exacerbation of liver steatosis, likely via the decrease of oxidative stress and lipogenesis in the hepatocytes [22]. The primary objective of our study was to investigate the long-term effect of the interaction between the LJ as a high source of AA and 15-min GTD.…”

Section: Discussionmentioning

confidence: 99%

Lemon Juice Counteracts the Effect of Green Tea Decoction on Body Weight Gains, High Fat Diet Induced-Liver Steatosis, Total Antioxidant Status and Some Metabolic Parameters in Rats

Abid¹

2015

IJNFS

View full text Add to dashboard Cite

Background: In previous studies, we reported that green tea decoction (GTD) cooked in boiling water for 15-min (15-min GTD) reduced body weight gain (BWG), glucose and lipid absorption and improved total antioxidant status (TAS) of rats fed normal or high-fat diet (HFD). However, the long-term effect of a mixture: 15-min GTD + lemon juice (LJ) on BWG, liver steatosis (LS), TAS, blood glucose and lipids is still unknown. Purpose The aim of the present study is to examine the long-term effect of 15-min GTD + LJ mixture on above parameters in rats fed HFD induced-obesity and LS. Methods Twentyeight male rats were assigned to four groups with comparable body weights. During 9-weeks treatment, rats were given adlibitum a basic diet (BD) or HFD to promote obesity and LS. The group 1 received the BD (BD group), the group 2 received HFD (HFD group), the group 3 received HFD + 15-min GTD (GTD group) and the group 4 received HFD + a mixture: 15-min GTD and LJ (GTDLJ group). Results The rats fed HFD had the highest BWG associated with an abundant LS spread than rats consumed BD. However, 15-min GTD significantly reduced the BWG and LS spread (p<0.001). GTD group showed also decreased plasma glucose, triglycerides and increased both TAS and GPX activities (p<0.05 and p<0.01, respectively). Surprisingly, an abundant reappearance of several LS spread and a restore of BWG were observed in GTDLJ group compared to GTD group. The GTDLJ mixture also reversed the GTD effect on plasma glucose, TAS, GPX and blood iron. Conclusion These results show that 15-min GTD significantly reduces BWG, HFD induced-LS, plasma glucose, triglycerides, blood iron and improves TAS and GPX. However, the GTDLJ mixture partially or totally counteracts the effect of 15-min GTD on BWG, LS, plasma glucose, blood iron, TAS and GPX.

show abstract

Section: Discussionmentioning

confidence: 99%

Lemon Juice Counteracts the Effect of Green Tea Decoction on Body Weight Gains, High Fat Diet Induced-Liver Steatosis, Total Antioxidant Status and Some Metabolic Parameters in Rats

Abid¹

2015

IJNFS

View full text Add to dashboard Cite

show abstract

“…Iron overload (hemochromatosis):Iron plays a role in the genesis of ALD 37,78 Dietary factor: Malnutrition like vitamin A and E deficiencies may worsen alcohol-induced liver damage by preventing regeneration of hepatocytes. This is particularly a concern as alcoholics are usually malnourished because of a poor diet, anorexia, and encephalopathy 77 .…”

Section: The Risk Factors For Alcoholic Liver Disease(ald)mentioning

confidence: 99%

Addiction and Liver Disease

2014

View full text Add to dashboard Cite

show abstract

“…Iron overload is associated with increased liver inflammatory response due to the production of reactive oxygen species and may impair immune response against HCV virus infection. Therefore, it is a key mechanism of liver injury among patients with HCV infection and excessive ethanol consumption 26 .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Hepatitis C in alcoholic liver disease.

Oberoi¹,

Singh²,

Aloona³

et al. 2017

Int. J. Curr. Res. Med. Sci.

View full text Add to dashboard Cite

Alcohol consumption and hepatitis C virus (HCV) infection have a synergic hepatotoxic effect, and the coexistence of these factors increases the risk of advanced liver disease. The main mechanisms of this effect are increased viral replication and altered immune response, although genetic predisposition may also play an important role. Traditionally, HCV prevalence has been considered to be higher (up to 50%) in alcoholic patients than in the general population. Due to the toxic combined effect of HCV and alcohol, patients with HCV infection should be screened for excessive ethanol intake. Patients starting treatment for HCV infection should be specifically advised to stop or reduce alcohol consumption because of its potential impact on treatment efficacy and adherence and may benefit from additional support during antiviral therapy. This recommendation might be extended to all currently recommended drugs for HCV treatment. In Our study on 194 patients of ALD, we found anti Hcv ab was positive in 18.6% of patients of ALD. Most of cases had developed cirrhosis and its complications. Of all Anti HCV Ab positive patients 55.6% presented with Gastrointestinal bleeding and 46.7% with Hepatic encephalopathy. The mean value of SGOT and SGPT were significantly higher in Anti HCV Ab positive patients as compared to Anti Hcv ab negative patients. The study concluded that alcoholics who are Anti HCV Ab positive are more prone to develop cirrhosis of liver with its various complication

show abstract

Role of iron in alcoholic liver disease: introduction and summary of the symposium

Cited by 45 publications

References 8 publications

Lemon Juice Counteracts the Effect of Green Tea Decoction on Body Weight Gains, High Fat Diet Induced-Liver Steatosis, Total Antioxidant Status and Some Metabolic Parameters in Rats

Lemon Juice Counteracts the Effect of Green Tea Decoction on Body Weight Gains, High Fat Diet Induced-Liver Steatosis, Total Antioxidant Status and Some Metabolic Parameters in Rats

Addiction and Liver Disease

Prevalence of Hepatitis C in alcoholic liver disease.

Contact Info

Product

Resources

About