Role of intracellular events in the pathogenesis of dengue; An overview

Jain, Bhawana; Chaturvedi, U. C.; Jain, Amita

doi:10.1016/j.micpath.2014.03.004

Cited by 27 publications

(19 citation statements)

References 92 publications

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“…The intracellular localization of each kinase is associated to the different pathways and stress sensors that culminate in the final event of eIF2 phosphorylation and translation inhibition. The HRI kinase (eIF2K1) is activated in heme deprivation and oxidative stress with ROS release; PKR is the cytoplasmic kinase (eIF2K2) activated by viral infection and foreign dsRNA; PERK/PEK (eIF2K3) is associated to ER and related to UPR pathway, as described before; and GCN2 (eIF2K4) is activated by amino acid starvation and UV irradiation (Bertolotti et al, 2000; Daito et al, 2014; Jain et al, 2014). Those kinases cause the phosphorylation of the eIF2-α at Ser51, which impairs its binding to eIF2B, inhibiting GDP-GTP exchange, which is necessary for Met tRNA position on the 43S ribosomal subunit and initiation of translation (Kedersha et al, 2002).…”

Section: Cellular Stress Pathwaysmentioning

confidence: 95%

Interplay between Inflammation and Cellular Stress Triggered by Flaviviridae Viruses

2016

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The Flaviviridae family comprises several human pathogens, including Dengue, Zika, Yellow Fever, West Nile, Japanese Encephalitis viruses, and Hepatitis C Virus. Those are enveloped, single-stranded positive sense RNA viruses, which replicate mostly in intracellular compartments associated to endoplasmic reticulum (ER) and Golgi complex. Virus replication results in abundant viral RNAs and proteins, which are recognized by cellular mechanisms evolved to prevent virus infection, resulting in inflammation and stress responses. Virus RNA molecules are sensed by Toll-like receptors (TLRs), RIG-I-like receptors (RIG-I and MDA5) and RNA-dependent protein kinases (PKR), inducing the production of inflammatory mediators and interferons. Simultaneously, the synthesis of virus RNA and proteins are distinguished in different compartments such as mitochondria, ER and cytoplasmic granules, triggering intracellular stress pathways, including oxidative stress, unfolded protein response pathway, and stress granules assembly. Here, we review the new findings that connect the inflammatory pathways to cellular stress sensors and the strategies of Flaviviridae members to counteract these cellular mechanisms and escape immune response.

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Section: Cellular Stress Pathwaysmentioning

confidence: 95%

Interplay between Inflammation and Cellular Stress Triggered by Flaviviridae Viruses

2016

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“…Transmitted to humans via mosquitos, it can cause severe and widespread disease, including hemorrhagic fever [139]. The capsid of dengue virus is initially synthesized on the ER and then transiently accumulates on LDs [140, 141].…”

Section: 1 Protein Maturationmentioning

confidence: 99%

Lipid droplet functions beyond energy storage

Welte

Gould

2017

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

442

358

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Lipid droplets are cytoplasmic organelles that store neutral lipids and are critically important for energy metabolism. Their function in energy storage is firmly established and increasingly well characterized. However, emerging evidence indicates that lipid droplets also play important and diverse roles in the cellular handling of lipids and proteins that may not be directly related to energy homeostasis. Lipid handling roles of droplets include the storage of hydrophobic vitamin and signaling precursors, and the management of endoplasmic reticulum and oxidative stress. Roles of lipid droplets in protein handling encompass functions in the maturation, storage, and turnover of cellular and viral polypeptides. Other potential roles of lipid droplets may be connected with their intracellular motility and, in some cases, their nuclear localization. This diversity highlights that lipid droplets are very adaptable organelles, performing different functions in different biological contexts.

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“…Dengue is a common hemorrhagic viral infectious disease (Jain, Chaturvedi, & Jain, 2014). An obvious evidence indicated that inflammatory responses are activated by NLRP3 inflammasomes during dengue virus infection.…”

Section: Lipophagy Aggravation Dengue Virus Infectionmentioning

confidence: 99%

Lipophagy in nonliver tissues and some related diseases: Pathogenic and therapeutic implications

Zhou

Yao

et al. 2018

Journal Cellular Physiology

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Lipid autophagy (lipophagy) is defined as a selective autophagy process in which some intracellular lipid droplets are selectively degraded by autophagic lysosomes pathway. The occurrence of lipophagy was first discovered in liver tissues. Additionally, abundant evidence indicated that the occurrence of hepatic lipophagy has been implicated in many liver diseases including fatty liver diseases, nonalcoholic fatty liver diseases, liver fibrosis, and liver cirrhosis. However, recent studies suggested that hepatic lipophagy occurs not only in liver tissue but also in other nonliver tissues and cells. Furthermore, the occurrence of lipophagy plays a crucial role in nonliver tissues and some related diseases. For instance, lipophagy relieves insulin resistance in adipose tissue from obesity patient with type 2 diabetes. Additionally, lipophagy has the ability to remit neurodegenerative diseases by reducing activity‐dependent neurodegeneration in nervous tissue. Lipophagy decreases muscle lipid accumulation and accordingly improves lipid storage myopathy in muscle tissue. Moreover, lipophagy alleviates the malignancy and metastasis of cancer in clear renal cell carcinoma tissue. Lipophagy is also involved in other processes, such as spermatogenesis, osteoblastogenesis, and mucosal ulceration. In conclusion, targeting lipophagy may be a critical regulator and a new therapeutic strategy for nonliver tissues and some related diseases.

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Role of intracellular events in the pathogenesis of dengue; An overview

Cited by 27 publications

References 92 publications

Interplay between Inflammation and Cellular Stress Triggered by Flaviviridae Viruses

Interplay between Inflammation and Cellular Stress Triggered by Flaviviridae Viruses

Lipid droplet functions beyond energy storage

Lipophagy in nonliver tissues and some related diseases: Pathogenic and therapeutic implications

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