Role of intestinal probiotics in the modulation of lipid metabolism: implications for therapeutic treatments

Song, Xiaoran; Liu, Yanan; Zhang, Xin; Weng, Peifang; Zhang, Ruilin; Wu, Zufang

doi:10.1016/j.fshw.2023.02.005

Cited by 9 publications

(1 citation statement)

References 106 publications

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“…The participation of Oscillospira in modulating the immune system and facilitating the alleviation of intestinal inflammation has been established (Konikoff & Gophna, 2016). Other beneficial bacteria, such as Lactococcus, could produce cholesterol-degrading enzymes, vitamins, and other valuable metabolites (Song et al, 2023). Most of these bacteria belong to genera that produce SCFAs.…”

Section: Discussionmentioning

confidence: 99%

Exploring and comparing the anti‐obesity mechanisms of defatted rice bran total dietary fiber, insoluble dietary fiber, and soluble dietary fiber based on multi‐omics technologies

Zheng,

Zhao,

et al. 2024

Food Frontiers

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This study aimed to investigate the anti‐obesity mechanisms of rice bran total dietary fiber (RDF), rice bran insoluble DF (RIDF), and rice bran soluble DF (RSDF) from defatted rice bran. RDF, RIDF, and RSDF exhibited excellent anti‐obesity effects, mainly reflected in lipid adsorption in vitro, reduction of body weight, inhibition of adipose tissue accumulation, improvement of dyslipidemia, and repair of histopathological damage. More importantly, the analysis of multi‐omics results revealed that the regulation of intestinal microbiota, amino acid metabolism, and lipid metabolism were the critical pathways for the anti‐obesity effects of RDF, RIDF, and RSDF. However, RIDF was involved in lipid metabolism through alanine, aspartate, and glutamate metabolism and exhibited a more favorable regulatory effect on gut microbiota. In contrast, RSDF impacted metabolic pathways dominated by tryptophan and cholesterol metabolism and excelled in immune and inflammatory amelioration. RIDF and RSDF together constitute RDF, with the latter integrating the tendencies of RIDF and RSDF in terms of intestinal microbiota and hepatic gene expression. However, RDF exhibited significant differences in metabolic regulation compared to RIDF and RSDF, particularly concerning tryptophan metabolism. These findings demonstrated that RIDF and RSDF have distinct mechanisms in obesity management, and that both contributed differently to the anti‐obesity effect of RDF. This study provides experimental evidence for the development of different types of DF from defatted rice bran as personalized anti‐obesity dietary supplements. It also offers new insights for future precision nutrition interventions involving DF.

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Section: Discussionmentioning

confidence: 99%

Exploring and comparing the anti‐obesity mechanisms of defatted rice bran total dietary fiber, insoluble dietary fiber, and soluble dietary fiber based on multi‐omics technologies

Zheng,

Zhao,

et al. 2024

Food Frontiers

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Effects of different lipid sources with or without a probiotic on gastrointestinal tract, immune system and blood parameters of chickens: An animal model

Poorghasemi,

Chamani,

Mirhosseini

et al. 2024

Lipids

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The objective of this study was to determine the effects of different lipid sources, with or without a probiotic, on the gastrointestinal tract, immune system and blood parameters of Ross 308 male chickens. In this study, 360 one‐day‐old chickens were randomly allotted to six treatments with six replicates. Experimental diets were: (1) control (CTL); (2) a diet containing 30 g/kg lipid from tallow (CTL+TLW); (3) a diet containing 30 g/kg lipid from soybean oil (CTL+SO); (4) the basal diet plus a probiotic (CTL+PRO), (5) a diet containing 30 g/kg tallow plus probiotic (TLW+PRO); and (6) a diet containing 30 g/kg soybean oil plus probiotic (SO+PRO). The percentage of liver and jejunum in the treatments that used tallow alone or tallow with probiotics had a significant increase as compared to the control. The villus height and crypt depth of the ileum and villus height/crypt depth in the treatments that used soybean oil and probiotic alone had a significant increase compared to the control. The weight of the spleen, bursa of Fabricius, and thymus in the treatments that used probiotics had a significant increase compared to the control. The amount of alkaline phosphatase and alanine aminotransferase as well as triacylglycerol in the treatment containing probiotic and its mixture with soybean oil had the least significant difference with the control. The results showed that the use of soybean oil, probiotics, and their mixture can improve intestinal morphology, strengthen the immune system, and reduce liver enzymes in chickens.

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Dietary Bacillus species modulate lipid metabolism-related parameters, growth, water quality, and bacterial load in Nile tilapia (Oreochromis niloticus )

Atef,

Ahmed,

Said

et al. 2024

Animal Feed Science and Technology

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Role of intestinal probiotics in the modulation of lipid metabolism: implications for therapeutic treatments

Cited by 9 publications

References 106 publications

Exploring and comparing the anti‐obesity mechanisms of defatted rice bran total dietary fiber, insoluble dietary fiber, and soluble dietary fiber based on multi‐omics technologies

Exploring and comparing the anti‐obesity mechanisms of defatted rice bran total dietary fiber, insoluble dietary fiber, and soluble dietary fiber based on multi‐omics technologies

Effects of different lipid sources with or without a probiotic on gastrointestinal tract, immune system and blood parameters of chickens: An animal model

Dietary Bacillus species modulate lipid metabolism-related parameters, growth, water quality, and bacterial load in Nile tilapia (Oreochromis niloticus )

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