ROLE OF INTERLEUKIN-8 IN PREDICTING ENDOMETRIOSIS IN PATIENTS WITH CHRONIC PELVIC PAIN &amp; INFERTILITY

Singh, Amrita; Pandey, Kiran; Arya, Sangeeta; Ahmad, Ayesha; Khatoon, Fareha

doi:10.24041/ejmr2020.30

Cited by 2 publications

(5 citation statements)

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“…In the present study, 35.3% of the studied women suffered from dysmenorrhea, which was significantly higher in the infertile group. These findings were consistent with the findings of previous studies (8,12,(16)(17)(18)21). Also, there was a significant correlation between the history of surgery between the two groups with CPPS, which is consistent with previous studies (24,25).…”

Section: Discussionsupporting

confidence: 93%

“…Although, according to the general definition, CPPS is defined as pain with no structural cause (13), in some sources, endometriosis, adhesions, irritable bowel syndrome, and interstitial cysts have been proposed as four common causes of this complication (12). In the present study, 35.3% of the studied women suffered from dysmenorrhea, which was significantly higher in the infertile group.…”

Section: Discussionmentioning

confidence: 48%

“…Mothers who have daughters are concerned that their daughters may develop endometriosis in the future and suffer from pain and infertility (17). It should be noted that not only the pain caused by endometriosis but also the emotional problems associated with this disease, such as feelings of guilt and distress at work, are effective on the quality of life, and all these cases can be effective in aggravating CPPS (12,24).…”

Section: Discussionmentioning

confidence: 99%

“…Argentino et al (3) reported a study in New Zealand on 2,261 women aged 18-50 years that among the participants, the three-month prevalence of chronic pelvic pain was 25.4%, and about half of these women (47.7%) were undiagnosed. Singh et al (12) showed that until that date, only 18 epidemiological studies were conducted on the frequency of non-periodic pelvic pain, which was reported as 1.2-24%. The studies conducted on the frequency of CPPS while expressing the importance and extent of the issue and the need to address it, indicate that there is still no consensus among researchers, even on the basic concepts and definition of CPPS, which causes dispersion in the findings of epidemiological studies.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of laparoscopy results for the patients with chronic pelvic pain

MADENLİ>

ÖZTÜRK

2022

Journal of Medicine and Palliative Care

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Aim: The study aims to retrospectively evaluate the laparoscopy results of patients who underwent laparoscopy with chronic pelvic pain (CPPS) diagnosis in two groups of fertile and infertile patients. Material and Method: This retrospective study examined the electronic records of 170 patients who underwent laparoscopy due to CPPS were included in the study. The patients were divided into two groups: the CPPS and unexplained infertility group (n: 87) as the case group and the CPPS fertile group (n: 83) as the control group. Women aged 25-40 years with unexplained infertility and CPPS were included in the study. Results: Results found a statistically significant association between infertility in women and laparoscopy results (p0.05). There was no statistically significant association between women’s infertility and smoking status (p>0.05). Mann-Whitney test did not find a statistically significant association between case and control regarding age and body mass index (BMI) (p>0.05). There was a statistically significant difference between groups in terms of the duration of pain (p

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of laparoscopy results for the patients with chronic pelvic pain

MADENLİ>

ÖZTÜRK

2022

Journal of Medicine and Palliative Care

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“…Так, A. Singth та співавт. показують, що зростання вмісту прозапального ІЛ-8 у перитонеальній рідині жінок з ендометріозом корелює з неплідністю [17].…”

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Effectiveness of vaccination in the treatment of early lesions of the cervix in women with infertility

Shalko,

Sereda

2024

UJHW

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Infertility is a common pathology that has not only medical, but powerful social and economic consequences. The aim of the study - to investigate the impact of human papillomavirus (HPV) vaccination on indicators of local cervical immunity in women with infertility. Materials and methods. 133 patients with infertility were examined, in whom abnormal cytological findings and DNA of one or more HPV strains were detected during the initial examination. Among them, 28 women had infertility of endocrine origin (the Group I), 52 women had tubo-peritoneal origin (the Group II) and 53 patients had male factors of infertility (the Group III). After treatment, which included the elimination of pathogens and excision of the affected epithelium, the patients were divided into subgroups A and B. Subgroup IA included 13 patients, subgroup IV included 13 patients, IIA included 28 patients, IIV included 24 patients, IIIA included 27 patients, IIIB included 26 patients. Patients of subgroup A were offered vaccination with a 2-component vaccine against HPV, patients of subgroup B were limited to traditional therapy. In the control group were 37 healthy women with normal cytological results. The concentration of interleukin 8 (IL-8), IL-6, lactoferrin (L) and secretory leukocyte proteinase inhibitor (SLPI) was assessed before the start of treatment, 3 and 6 months after treatment. Results. In all patients with infertility and early cervical lesions (ECL), a three-fold increased concentration of IL-8, IL-6, as well as SLPI and L, which has a direct impact on fertility disorders, was found. Against the background of traditional therapy, a decrease in IL-6 was found in all patients after 6 months, and in patients with infertility of endocrine origin was found in the concentration of L. Additional vaccination allows to achieve a decrease in the cervical content of all inflammatory markers within 6 months, which is important for the further restoration of reproductive function. Conclusions. Increased cervical content of pro-inflammatory markers: IL-6, IL-8, SLPI and L, which are important in the pathogenesis of reproductive function disorders, were found in patients with ECL against the background of infertility. Against the background of anti-inflammatory therapy and surgical treatment for 6 months, there is a slight decrease in the cervical concentration of IL-8 and SLPI. Vaccination with a bivalent vaccine against HPV in combination with anti-inflammatory therapy and surgical treatment in women with ECL and infertility led to the normalization of the concentration of pro-inflammatory markers in cervical mucus. The research was carried out in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the work. Informed consent of the women was obtained for the research. No conflict of interests was declared by the authors.

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ROLE OF INTERLEUKIN-8 IN PREDICTING ENDOMETRIOSIS IN PATIENTS WITH CHRONIC PELVIC PAIN & INFERTILITY

Cited by 2 publications

References 0 publications

Evaluation of laparoscopy results for the patients with chronic pelvic pain

Evaluation of laparoscopy results for the patients with chronic pelvic pain

Effectiveness of vaccination in the treatment of early lesions of the cervix in women with infertility

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