Role of Interleukin 6–174G>C Polymorphism in Primary Open-Angle Glaucoma

Abstract

Our findings suggest that the functional IL-6-174G>C polymorphism itself is unlikely a major risk factor for POAG.

Interleukin-6(-174) Locus Polymorphism and Serum IL-6 Levels in Normal Tension Glaucoma

“…Our results are similar to Zimmermann's study in a primary open angle glaucoma group. 5 These results of our study revealed that serum IL-6 value was a borderline higher in NTG patients compared to controls. These results are similar to the results of Huang and colleagues who found that serum levels of IL-6 were higher in POAG patients.…”

Neuroprotective effects of intravitreally transplanted adipose tissue and bone marrow–derived mesenchymal stem cells in an experimental ocular hypertension model

“…Oh et al [102] showed that human MSCs secrete small amounts of IL-6 and large amounts of TGF-b1 into the culture medium, and this secretion affected the recovery of the apoptotic tissues [102,103]. It has been reported that IL-6 protects retinal ganglion cells from pressureinduced apoptosis, indicating a possible role in the pathogenesis of primary open-angle glaucoma because of its proinflammatory and antiapoptotic effects [104]. The increased level of IL-6 secretion might be explained by the regulation of human MSCs in the co-culture with chemically damaged human corneal epithelial cells [105,106].…”

Association of interleukin-6 gene polymorphisms and glaucoma: Systematic review and meta-analysis

“…29 Therefore, previous studies have interests in the association between IL-6 polymorphisms and glaucoma including POAG and NTG in different populations. 11,[17][18][19][20] For example, Zimmermann et al reported that the IL-6 rs1800795 polymorphism is unlikely associated with POAG. 18 Lin et al found that the IL-6 rs1800795 polymorphism is not significantly associated with NTG in Chinese population.…”

“…The present study involved four case-control studies [17][18][19][20] with a total of 760 cases and 799 controls, and characteristics of these selected studies are summarized in Table 1. The publication years of these included studies were between 2010 and 2016.…”

“…Zimmermann et al suggested that functional IL-6 rs1800795 (−174 G/C) polymorphism is unlikely to be a major risk factor for POAG. 18 Lin et al demonstrated no significant associations between IL-6 rs1800795 (−174 G/C) polymorphism and NTG in the Chinese population. 19 The distribution of the IL-6 rs1800795 (−174 G/C) polymorphism indicated no significant differences between patients and controls.…”