Role of Interleukin-34 in Cancer

Franzè, Eleonora; Stolfi, Carmine; Troncone, Edoardo; Scarozza, Patrizio; Monteleone, Giovanni

doi:10.3390/cancers12010252

Cited by 36 publications

(29 citation statements)

References 60 publications

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“…These findings confirm and expand on the data of previous studies showing that monocytes/macrophages are the main targets of IL-34 17 . Our data are also in line with studies documenting the expression of IL-34 receptors in TAMs in other settings 7 . Next, we showed that CD68/ HLA-DRII-positive cells expressed IL-34 in both TICs and LPMCs preparations, even though the fraction of IL-34-positive cells was significantly higher in cancer cancer 19,20 .…”

Section: Discussionsupporting

confidence: 92%

“…In this context, we have recently shown that CRC cells synthesize IL-34, a factor that expands CRC cell 6 . Interestingly, both neoplastic cells and nontumoral cells infiltrating CRC tissue express IL-34 receptors raising the possibility that IL-34 can mediate the cross-talk between cancer cells and other cells during colon carcinogenesis process 7 . This study was undertaken to examine whether IL-34 regulates the function of TAMs, as these cells are known to facilitate CRC progression 15 .…”

Section: Discussionmentioning

confidence: 99%

“…Within the tumor tissue, other cell types (i.e., stromal cells and cancer cells themselves) can secrete factors promoting CRC cell growth and survival 5 . For instance, we have recently shown that interleukin-34 (IL-34), a cytokine that regulates monocyte/macrophage functions, is highly produced in CRC 6,7 . Immunohistochemistry analysis of CRC sections showed that cancer cells were the major source of IL-34, even though it was also produced to a lesser extent by lamina propria mononuclear cells (LPMCs) 6 .…”

Section: Introductionmentioning

confidence: 99%

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Macrophages produce and functionally respond to interleukin-34 in colon cancer

et al. 2020

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In colorectal cancer (CRC), macrophages represent a major component of the tumor mass and exert mostly functions promoting tumor cell survival, proliferation, and dissemination. Interleukin-34 (IL-34) is a cytokine overproduced by colon cancer (CRC) cells and supposed to make a valid contribution to the growth and diffusion of CRC cells. The biological functions of IL-34 are mediated by the macrophage colony-stimulating factor receptor (M-CSFR-1), which controls monocyte/macrophage differentiation, growth, and survival. We here investigated whether, in CRC, tumor-associated macrophages (TAMs) express M-CSFR-1 and functionally respond to IL-34. By flow-cytometry analysis of tumor-infiltrating cells (TICs) and lamina propria mononuclear cells (LPMCs) isolated from normal, adjacent mucosa of CRC patients, we showed that CD68/HLA-DRII-expressing TICs and LPMCs expressed M-CSFR-1. Both these cell types produced IL-34 even though the expression of the cytokine was more pronounced in TICs as compared to normal LPMCs. Moreover, in CRC samples, there was a positive correlation between IL-34-producing cells and CD68-positive cells. Stimulation of LPMCs and TICs with IL-34 resulted in enhanced expression of CD163 and CD206, two markers of type II-polarized macrophages, and this was evident at both RNA and protein level. In the same cell cultures, IL-34 stimulated expression and production of IL-6, a cytokine known to promote CRC cell growth and diffusion. Finally, knockdown of IL-34 in TICs with specific antisense oligonucleotides with: a specific antisesne oligonucleotide decreased IL-6 production and the number of TAMs producing this cytokine. This is the first to show a positive role of IL-34 in the control of TAMs in CRC, further supporting the notion that IL-34 sustains colon tumorigenesis.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Macrophages produce and functionally respond to interleukin-34 in colon cancer

et al. 2020

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“…Both cancer cells and immune cells can secrete various interleukins such as IL-34 (Franzè et al, 2020 ), which can increase the recruitment of M2 macrophages and promote the growth and metastasis of osteosarcoma (Ségaliny et al, 2015 ). There is increasing evidences that IL-34 promotes tumorigenesis through autocrine and paracrine mechanisms.…”

Section: Macrophage and Bone Remodeling-related Bone Diseasesmentioning

confidence: 99%

Communications Between Bone Marrow Macrophages and Bone Cells in Bone Remodeling

Chen

Jiao

Liu

et al. 2020

Front. Cell Dev. Biol.

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The mammalian skeleton is a metabolically active organ that continuously undergoes bone remodeling, a process of tightly coupled bone resorption and formation throughout life. Recent studies have expanded our knowledge about the interactions between cells within bone marrow in bone remodeling. Macrophages resident in bone (BMMs) can regulate bone metabolism via secreting numbers of cytokines and exosomes. This review summarizes the current understanding of factors, exosomes, and hormones that involved in the communications between BMMs and other bone cells including mensenchymal stem cells, osteoblasts, osteocytes, and so on. We also discuss the role of BMMs and potential therapeutic approaches targeting BMMs in bone remodeling related diseases such as osteoporosis, osteoarthritis, rheumatoid arthritis, and osteosarcoma.

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“…Lastly, in this Special Issue, the implication of IL-34 in cancer has been reviewed [ 10 ]. The Monteleone group has raised a great review about the multiple roles of IL-34 in various cancers.…”

Section: Special Issue “Interleukin In Cancer Pathogenesis and Trementioning

confidence: 99%