Role of interleukin‑32 in cancer progression (Review)

Abstract

Interleukin (IL)-32 is induced by pro-inflammatory cytokines and promotes the release of inflammatory cytokines. Therefore, it can promote inflammatory responses. The present review article summarized the role of the receptors required for IL-32 action, the biological function of IL-32 and its mechanism of action in tumors. Moreover, it assessed the significance of aberrant IL-32 expression in associated diseases and analyzed the effects of IL-32 on four key types of cancer: Colorectal, gastric, breast and lung. However, the mechanism of action of IL-32 needs to be further demonstrated by assessing the role of this cytokine in cancer to elucidate novel and reliable targets for future cancer treatments. Contents1. Introduction 2. Receptors for IL-32 action 3. Potential mechanism of IL-32 in cancer development 4. Role of IL-32 in cancer 5. Role of IL-32 in CRC 6. Role of IL-32 in gastric cancer 7. Role of IL-32 in breast cancer 8. Role of IL-32 in lung cancer 9. Conclusion