2014
DOI: 10.4103/1110-6530.150269
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Role of interleukin-23 in the immunopathogenesis of systemic lupus erythematosus

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Cited by 5 publications
(11 citation statements)
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“…Serum levels of IL-23 were determined for all patients and controls using a quantitative enzyme-linked immunosorbent assay. They found that serum IL-23 concentration was significantly elevated in SLE patients than in the healthy controls, and it correlated significantly with disease activity index [6]. Their findings support us as serum IL-23 levels were higher in SLE patients than healthy individuals and correlate positively with the SLEDAI score.…”
Section: Resultssupporting
confidence: 53%
“…Serum levels of IL-23 were determined for all patients and controls using a quantitative enzyme-linked immunosorbent assay. They found that serum IL-23 concentration was significantly elevated in SLE patients than in the healthy controls, and it correlated significantly with disease activity index [6]. Their findings support us as serum IL-23 levels were higher in SLE patients than healthy individuals and correlate positively with the SLEDAI score.…”
Section: Resultssupporting
confidence: 53%
“…In recent years, an increasing number of studies have been published analyzing the possible role of IL-23 and IL-27 (members of the IL-12 family) in the pathogenesis of SLE, and their potential contribution to immune imbalance [ 9 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. Differences in both IL-23 and IL-27 levels between patients with SLE and healthy controls were shown.…”
Section: Discussionmentioning
confidence: 99%
“…The role of both interleukins in the pathogenesis of SLE, their association with disease activity, and their therapeutic potential have been analyzed over the past decade; however, these studies were based on small sample sizes, and provided inconsistent results [ 20 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. In patients with SLE, it was shown that serum IL-23 concentration is higher [ 24 , 25 , 26 , 27 ] and IL-27 concentration is lower when compared to healthy controls [ 20 , 23 ]. Most authors found a positive correlation between IL-23 concentration and disease activity [ 24 , 28 ], and a lack of correlation between IL-27 levels and disease activity [ 20 ].…”
Section: Introductionmentioning
confidence: 99%
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