Role of interleukin-23 in the immunopathogenesis of systemic lupus erythematosus

Hegab, Doaa Salah; Gamei, Mohamed Mahmoud; Saudi, Wael M.; Ammo, Desoky Ezzat Abou; Bedewy, Mohamed Mohamed El; Elhabian, Naglaa Fathy

doi:10.4103/1110-6530.150269

Cited by 5 publications

(11 citation statements)

References 3 publications

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“…Serum levels of IL-23 were determined for all patients and controls using a quantitative enzyme-linked immunosorbent assay. They found that serum IL-23 concentration was significantly elevated in SLE patients than in the healthy controls, and it correlated significantly with disease activity index [6]. Their findings support us as serum IL-23 levels were higher in SLE patients than healthy individuals and correlate positively with the SLEDAI score.…”

Section: Resultssupporting

confidence: 53%

Cytokines (IL-17, IL-23 and IL-33) in Systemic lupus erythematosus in Trinidad and Tobago

Justiz-Vaillant¹,

Nobee

2020

Preprint

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The systemic lupus erythematosus (SLE) is the greatest manifestation of autoimmunity. It is characterized by the presence of cytokines, including type I and II interferons, interleukin-6 (IL-6), IL-1, and tumor necrosis factor-alpha (TNF-α), the immunomodulatory cytokines like IL-10 and TGF-β, be essential players in SLE. Additionally, T-cell-derived cytokines like IL-17A, IL-21, and IL-2 are dysregulated in SLE. In this paper, a prospective cross-sectional and observational study was done. It was measured the levels of 3 essential cytokines in SLE: IL-17A, IL-23, and IL-33 using three enzyme-linked immunosorbent assays (ELISA). Thirty (30) patients attending the rheumatoid clinic at one of the major regional hospitals in the Caribbean region were recruited. Mostly females above the childbearing age give their consent to be included in the study and other 30 healthy patients were used a control. Of all the SLE patients, 15 (50%) patients were of Afro-Caribbean descent, 12 (40%) of patients were of Indo-Caribbean descent, and 3 (10%) of patients were of mixed descent. Nineteen (63%) healthy controls were females, and 11 (37%) were males. The results showed that serum IL-17A and IL-23 were more significantly higher in SLE patients than controls (P<0.01); however, there was no statistically significant difference between IL-33 levels between SLE patients and healthy controls. The study showed no correlation between serum IL-17A and IL-23 in SLE patients as judged by the result of the Pearson correlation coefficient (r=0.308, p>0.05). It also showed that serum IL-17A and IL-23 levels positively correlate to the SLE disease activity index 2000 score (SLEDAI score). Nevertheless, IL-33 levels show no correlation with the SLEDAI score. In this study, higher cytokines were reported mostly in patients between the ages of 25 to 30-year-old and Afro-Caribbean descent.

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Section: Resultssupporting

confidence: 53%

Cytokines (IL-17, IL-23 and IL-33) in Systemic lupus erythematosus in Trinidad and Tobago

Justiz-Vaillant¹,

Nobee

2020

Preprint

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“…In recent years, an increasing number of studies have been published analyzing the possible role of IL-23 and IL-27 (members of the IL-12 family) in the pathogenesis of SLE, and their potential contribution to immune imbalance [ 9 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. Differences in both IL-23 and IL-27 levels between patients with SLE and healthy controls were shown.…”

Section: Discussionmentioning

confidence: 99%

“…The role of both interleukins in the pathogenesis of SLE, their association with disease activity, and their therapeutic potential have been analyzed over the past decade; however, these studies were based on small sample sizes, and provided inconsistent results [ 20 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. In patients with SLE, it was shown that serum IL-23 concentration is higher [ 24 , 25 , 26 , 27 ] and IL-27 concentration is lower when compared to healthy controls [ 20 , 23 ]. Most authors found a positive correlation between IL-23 concentration and disease activity [ 24 , 28 ], and a lack of correlation between IL-27 levels and disease activity [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…In patients with SLE, it was shown that serum IL-23 concentration is higher [ 24 , 25 , 26 , 27 ] and IL-27 concentration is lower when compared to healthy controls [ 20 , 23 ]. Most authors found a positive correlation between IL-23 concentration and disease activity [ 24 , 28 ], and a lack of correlation between IL-27 levels and disease activity [ 20 ]. Higher levels of IL-23 were also associated with LN [ 24 , 25 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

“…Most authors found a positive correlation between IL-23 concentration and disease activity [ 24 , 28 ], and a lack of correlation between IL-27 levels and disease activity [ 20 ]. Higher levels of IL-23 were also associated with LN [ 24 , 25 , 27 ]. Vukelic et al found that increased IL-23 levels are characteristic of patients with LN, but also patients with non-renal lupus.…”

Section: Introductionmentioning

confidence: 99%

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Lack of Association between Serum Interleukin-23 and Interleukin-27 Levels and Disease Activity in Patients with Active Systemic Lupus Erythematosus

Pawlak-Buś

Schmidt

Leszczyński

2021

JCM

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Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterized by the production of multiple autoantibodies, resulting in tissue and organ damage. Recent studies have revealed that interleukin-23 (IL-23) and interleukin-27 (IL-27) may be therapeutically relevant in selected SLE manifestations. This study aimed to identify associations between serum IL-27 and IL-23 levels and disease activity in Polish patients with different manifestations of SLE: neuropsychiatric lupus (NPSLE), and lupus nephritis (LN). Associations between interleukin levels and oligo-specific antibodies against double-stranded DNA (dsDNA), dose of glucocorticoids, and type of treatment were also analyzed. An enzyme-linked immunosorbent assay was used to assess anti-dsDNA antibodies and analyze the serum concentration of IL-27 and IL-23 from 72 patients aged 19–74 years with confirmed active SLE. Disease activity was measured using the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI 2-K). No significant correlations between interleukin levels and SLEDAI score, anti-dsDNA, corticosteroid dose, or type of treatment were noted. Patients with NPSLE and LN presented the highest median scores of SLEDAI.

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Interleukin-23 serum level in systemic lupus erythematosus patients: Relation to disease activity and different disease parameters

Rafat

Mohamed

Ahmed

et al. 2022

The Egyptian Rheumatologist

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Role of interleukin-23 in the immunopathogenesis of systemic lupus erythematosus

Cited by 5 publications

References 3 publications

Cytokines (IL-17, IL-23 and IL-33) in Systemic lupus erythematosus in Trinidad and Tobago

Cytokines (IL-17, IL-23 and IL-33) in Systemic lupus erythematosus in Trinidad and Tobago

Lack of Association between Serum Interleukin-23 and Interleukin-27 Levels and Disease Activity in Patients with Active Systemic Lupus Erythematosus

Interleukin-23 serum level in systemic lupus erythematosus patients: Relation to disease activity and different disease parameters

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