Role of interferon regulatory factor-mediated signaling in psoriasis

Wang, Wenming; Feng, Li; Jin, Hongzhong

doi:10.7150/ijms.61973

Cited by 5 publications

(3 citation statements)

References 70 publications

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“…The increased levels of TLR1, TLR2, TLR4, TLR7, and TLR9 perhaps promote the pathogenesis of immune-cell mediated inflammatory skin diseases. [ 55 ] There are interactions among these important signaling pathways, involving the response of cytokines and their receptors, the regulation of chemokines, and so on. For instance, cytokine-cytokine receptor interaction and chemokine binding to its receptor will activate JAK-STAT, PI3K-Akt, MAPK pathways, etc.…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology and molecular docking to explore the mechanism of a clinical proved recipe for external use of clearing heat and removing dampness in the treatment of immune-related cutaneous adverse events

Chen,

Yu,

Zhao

et al. 2024

Medicine

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Immune-related cutaneous adverse events (ircAEs) will undermine the patients’ quality of lives, and interrupt the antitumor therapy. A clinical proved recipe for external use of clearing heat and removing dampness (Qing-Re-Li-Shi Formula, hereinafter referred to as “QRLSF”) is beneficial to the treatment of ircAEs in clinical practice. Our study will elucidate the mechanism of QRLSF against ircAEs based on network pharmacology and molecular docking. The active components and corresponding targets of QRLSF were collected through traditional Chinese medicine systems pharmacology database. GeneCards, online Mendelian inheritance in man, and pharmacogenomics knowledgebase were used to screen the targets of ircAEs. The intersecting targets between drug and disease were acquired by venn analysis. Cytoscape software was employed to construct “components-targets” network. Search tool for the retrieval of interacting genes/proteins database was applied to establish the protein–protein interaction network and then its core targets were identified. Gene ontology and Kyoto encyclopedia of genes and genomes analysis was performed to predict the mechanism. The molecular docking verification of key targets and related phytomolecules was accomplished by AutoDock Vina software. Thirty-nine intersecting targets related to QRLSF against ircAEs were recognized. The analysis of network clarified 5 core targets (STAT3, RELA, TNF, TP53, and NFKBIA) and 4 key components (quercetin, apigenin, luteolin, and ursolic acid). The activity of QRLSF against ircAEs could be attributed to the regulation of multiple biological effects via multi-pathways (PI3K-Akt pathway, cytokine-cytokine receptor interaction, JAK-STAT pathway, chemokine pathway, Th17 cell differentiation, IL-17 pathway, TNF pathway, and Toll-like receptor pathway). The binding activities were estimated as good level by molecular docking. These discoveries disclosed the multi-component, multi-target, and multi-pathway characteristics of QRLSF against ircAEs, providing a new strategy for such medical problem.

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Section: Discussionmentioning

confidence: 99%

Network pharmacology and molecular docking to explore the mechanism of a clinical proved recipe for external use of clearing heat and removing dampness in the treatment of immune-related cutaneous adverse events

Chen,

Yu,

Zhao

et al. 2024

Medicine

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“…Moreover, IRF7 is highly expressed in keratinocytes and inflammatory cells of psoriatic skin, where IRF7 is involved in producing pro‐inflammatory cytokines and promoting the abnormal proliferation of epidermal cells 130 . IRF7 regulates the production of IFN‐I, which is a key factor in the development of plaque psoriasis 131 . Moreover, IRF7's impact on pDCs significantly drives the inflammatory cascade in psoriasis 132 .…”

Section: Irf7 In Cutaneous and Connective Tissue Diseasesmentioning

confidence: 99%

“…130 IRF7 regulates the production of IFN-I, which is a key factor in the development of plaque psoriasis. 131 Moreover, IRF7's impact on pDCs significantly drives the inflammatory cascade in psoriasis. 132 IRF7 also collaborates with IRF3 in the NF-kB signalling pathway to increase the production of IL-23 by DCs.…”

Section: Psoriasismentioning

confidence: 99%

Insight into the role of IRF7 in skin and connective tissue diseases

Wang,

Yang,

et al. 2024

Experimental Dermatology

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Interferons (IFNs) are signalling proteins primarily involved in initiating innate immune responses against pathogens and promoting the maturation of immune cells. Interferon Regulatory Factor 7 (IRF7) plays a pivotal role in the IFNs signalling pathway. The activation process of IRF7 is incited by exogenous or abnormal nucleic acids, which is followed by the identification via pattern recognition receptors (PRRs) and the ensuing signalling cascades. Upon activation, IRF7 modulates the expression of both IFNs and inflammatory gene regulation. As a multifunctional transcription factor, IRF7 is mainly expressed in immune cells, yet its presence is also detected in keratinocytes, fibroblasts, and various dermal cell types. In these cells, IRF7 is critical for skin immunity, inflammation, and fibrosis. IRF7 dysregulation may lead to autoimmune and inflammatory skin conditions, including systemic scleroderma (SSc), systemic lupus erythematosus (SLE), Atopic dermatitis (AD) and Psoriasis. This comprehensive review aims to extensively elucidate the role of IRF7 and its signalling pathways in immune cells and keratinocytes, highlighting its significance in skin‐related and connective tissue diseases.

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