The exploration of enzyme-mimic nanocomposites to replace
commercial
enzymes is challenging in the construction of biosensors with high
performance. Herein, an ultrafast response nonenzymatic glucose sensor
was developed based on a Cu2O–TiO2/Ti3C2T
x
nanocomposite,
which was prepared via an in situ redox procedure using Ti3C2T
x
nanosheets both as a
reducing agent and a carrier substrate. Structural characterizations,
including X-ray diffraction (XRD) and transmission electron microscopy
(TEM), revealed that Cu2O nanoparticles with a size of
10–30 nm are uniformly distributed on the surface of the Ti3C2T
x
nanosheets and
form close contacts through Ti–O–Cu bonds, resulting
in favorable stability of the system. The unique heterostructure of
Cu2O–TiO2/Ti3C2T
x
can produce abundant active sites
and facilitate electron transfer, demonstrating enhanced catalytic
activity in the electrooxidation of glucose. Consequently, the electrochemical
sensor fabricated by modifying a glassy carbon electrode (GCE) with
Cu2O–TiO2/Ti3C2T
x
nanocomposites exhibited excellent
analytical properties for glucose detection, including a fast response
time of 0.1 s, a low detection limit of 0.67 μM, and a high
sensitivity of 267 μA mM–1 cm–2. In addition, the developed method possesses good anti-interference
ability and superior stability and thus has been successfully applied
for real sample monitoring. This study offers a way to construct Ti3C2T
x
-based heterostructures
with tunable physiochemical properties and expands their use in the
electrochemical field.