Role of integrins and their ligands in osteoarthritic cartilage

Abstract

Osteoarthritis (OA) is a degenerative disease, which is characterized by articular cartilage destruction, and mainly affects the older people. The extracellular matrix (ECM) provides a vital cellular environment, and interactions between the cell and ECM are important in regulating many biological processes, including cell growth, differentiation, and survival. However, the pathogenesis of this disease is not fully elucidated, and it cannot be cured totally. Integrins are one of the major receptors in chondrocytes. A number of studies confirmed that the chondrocytes express several integrins including α5β1, αVβ3, αVβ5, α6β1, α1β1, α2β1, α10β1, and α3β1, and some integrins ligands might act as the OA progression biomarkers. This review focuses on the functional role of integrins and their extracellular ligands in OA progression, especially OA cartilage. Clear understanding of the role of integrins and their ligands in OA cartilage may have impact on future development of successful therapeutic approaches to OA.

18F-FPRGD2 PET/CT imaging of musculoskeletal disorders

“…This suggests that more integrins ( 18 F-FPRGD 2 uptake) are expressed by structures that show evidence of inflammation (FDG uptake). These observations in vivo are in agreement with our knowledge of the cross talk between integrins and cytokines/inflammatory mediators in vitro in chondrocytes or fibroblast-like synoviocytes [13,26,27,42]. A publication also showed that decrease of synovial inflammation using therapeutic intervention as assessed by a decrease in a composite clinical disease activity index significantly correlated to the decrease observed in 68 Ga-PRGD 2 SUV max [30].…”

“…Integrin a v b 5 is as relevant as integrin a v b 3 in OA pathophysiology [14,16,17,[25][26][27]. One of their ligands is vitronectin and it is noteworthy that its concentration in serum is increased with the Kellgren and Lawrence score [6,26,27].…”

“…Lastly, human discs showing morphological evidence of moderate degeneration express the integrin subunits a v and b 3 and expression of the complete integrin a v b 3 has been recently demonstrated and shows a trend of increased expression during degeneration [24,25]. Extensive and recent reviews confirm that integrins expression increases with the degree of cartilage damage in human OA [26,27]. Hence, several arguments support investigating PET imaging of integrin a v b 3 in musculoskeletal diseases with RGD-based radiopharmaceuticals.…”

Regulation of the Contribution of Integrin to Cell Attachment on Poly(2-Methoxyethyl Acrylate) (PMEA) Analogous Polymers for Attachment-Based Cell Enrichment

“…Generally, cells attached to FBS protein-coated substrates via integrin α5β1-FN and integrin αvβ3-vitronectin interactions [ 11 , 17 , 18 ]. The integrin expression levels were measured with semi-quantitative RT-PCR to gain understanding of the reason for the differences in the attachment among HT-1080, MDA-MB-231, and HepG2 cells ( Fig 5C ).…”

High temperature requirement A1 and fibronectin: two possible players in placental tissue remodelling

“…FN is involved in important process such as wound healing, cell adhesion and spreading, growth, migration, and differentiation. 12 The purpose of this study was to analyse the expression patterns of HtrA1 in relationship to FN and to the key growth zones of placenta during the first trimester of gestation.…”