Role of insulin on the control of postnatal increase in ornithine transcarbamylase activity in rat liver

Gautier, C.; Vaillant, R.

doi:10.1016/0006-291x(84)90415-7

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…Recent stud ies [20] show that glucocorticosteroids are able to stimulate liver insulin receptor syn thesis in vitro. These findings are in agree ment with observations made after birth [7,8]. We can note the similarity between the two situations: the fetus and the neonate with glu cose supply.…”

Section: Discussionsupporting

confidence: 82%

“…In further experi ments, we found that the inhibitory effect of glucose on postnatal increase in OTC activity might be associated with the resulting in crease in insulinemia [7]. Since an actinomy cin D supply overcame the inhibitory effect of glucose on enzyme activity and decreased insulinemia, the antibiotic might act by in hibiting insulin synthesis or insulin re lease [8].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Corticosteroids and Pancreatic Hormones on Carbamyl Phosphate Synthetase-I and Ornithine Transcarbamylase Activities in Fetal Rat Liver

Gautier¹,

Habechi²,

Belbekouche³

et al. 1985

Neonatology

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The effects of corticosteroids and pancreatic hormones on two mitochondrial enzymes of ureagenesis, carbamyl phosphate synthetase-I (CPS-I) and ornithine transcarbamylase (OTC), were investigated and compared in fetal rat liver. Supplementing hydrocortisone acetate (50 μg) to 18.5-day-old fetuses significantly increased CPS-I activity (by 36%) and decreased OTC activity (by 23%). An actinomycin D supply (2 μg) to 18.5-day-old fetuses prematurely increased OTC activity and decreased fetal insulin level (by 42%). This treatment had no effect on CPS-I activity. Glucagon supply (25 μg) during the late fetal period increased both activities within 2 h, while dibutyryl-cAMP enhanced OTC activity 17 h later. These results suggested that the fetal development of CPS-I activity was under the control of corticosteroids and glucagon. In contrast, corticosteroid hormones produced an inhibitory effect on OTC activity. This might be explained by the permissive effect of corticosteroids on insulin action, since insulin might act as a repressor in utero of enzyme development. Thus, the paradoxical effect of actinomycin D on OTC activity was probably due to the decrease in fetal insulinemia.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Effects of Corticosteroids and Pancreatic Hormones on Carbamyl Phosphate Synthetase-I and Ornithine Transcarbamylase Activities in Fetal Rat Liver

Gautier¹,

Habechi²,

Belbekouche³

et al. 1985

Neonatology

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Changes in ornithine transcarbamylase activity and protein level during perinatal period in rat liver. Effects of actinomycin D

Belbekouche

Gautier

Vaillant

1985

Biochemical and Biophysical Research Communications

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Origins of Specialized Pastoral Production in East Africa

Marshall

1990

American Anthropologist

104

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The results of recent archeological research in the Loita‐Mara area of Kenya offer new information on the timing and process of the development of pastoralism in East Africa. They suggest that a pattern of specialized pastoral production, similar to that of contemporary East African pastoralists such as the Maasai, was present in parts of East Africa 2,000 years ago. It may have developed as a result of new opportunities for increased pastoral production. A bimodal pattern of rainfall with a short dry season, similar to the modern climatic regime, appeared about 3,000 years ago, which allowed year‐round milk production from cattle herds. The development of pastoralism in East Africa preceded agriculture and took place in a social and economic context of relationships between hunter‐gatherers and pastoralists. Environmental opportunity, combined with cultural competition, may have provided the impetus toward pastoral specialization.

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Role of insulin on the control of postnatal increase in ornithine transcarbamylase activity in rat liver

Cited by 3 publications

References 17 publications

Effects of Corticosteroids and Pancreatic Hormones on Carbamyl Phosphate Synthetase-I and Ornithine Transcarbamylase Activities in Fetal Rat Liver

Effects of Corticosteroids and Pancreatic Hormones on Carbamyl Phosphate Synthetase-I and Ornithine Transcarbamylase Activities in Fetal Rat Liver

Changes in ornithine transcarbamylase activity and protein level during perinatal period in rat liver. Effects of actinomycin D

Origins of Specialized Pastoral Production in East Africa

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