Role of Inositol-Requiring Enzyme 1 and Autophagy in the Pro-Fibrotic Mechanism Underlying Graves’ Orbitopathy
Chae Eun Lee,
Ji-Young Kim,
Jin Sook Yoon
et al.
Abstract:Purpose
Orbital fibroblasts play key roles in the pathogenesis of Graves’ orbitopathy (GO), and previous findings have shown that endoplasmic reticulum (ER) stress and autophagy also contribute to GO. In this study, we investigated the presently unclear roles of inositol-requiring enzyme 1 (IRE1) and related autophagy processes in the pro-fibrotic mechanism of GO.
Materials and Methods
Orbital adipose/connective tissues were obtained from eight GO patients and six norma… Show more
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