Role of Inorganic Amorphous Constituents in Highly Mineralized Biomaterials and Their Imitations

Zhao, Hewei; Liu, Shaojia; Yang, Xiuyi; Guo, Lin

doi:10.1021/acsnano.2c05262

Cited by 16 publications

(11 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mg-amorphous calcium phosphate (ACP) was proposed as an intergranular phase in normal rodent enamel; and in another experiment, by comparison with an iron-rich enamel named pigmented enamel, it was hypothesised that the presence of Mg-ACP lowers the acid resistance of enamel in comparison with iron phosphate. Human enamel was also characterised using APT, revealing its atomic level composition, and at the interface regions between HAp crystallites, Mg-rich ACP was found [ 93 , 94 ].…”

Section: Demineralisation and Remineralisation Of Teethmentioning

confidence: 99%

Synchrotron X-ray Studies of the Structural and Functional Hierarchies in Mineralised Human Dental Enamel: A State-of-the-Art Review

et al. 2023

View full text Add to dashboard Cite

Hard dental tissues possess a complex hierarchical structure that is particularly evident in enamel, the most mineralised substance in the human body. Its complex and interlinked organisation at the Ångstrom (crystal lattice), nano-, micro-, and macro-scales is the result of evolutionary optimisation for mechanical and functional performance: hardness and stiffness, fracture toughness, thermal, and chemical resistance. Understanding the physical–chemical–structural relationships at each scale requires the application of appropriately sensitive and resolving probes. Synchrotron X-ray techniques offer the possibility to progress significantly beyond the capabilities of conventional laboratory instruments, i.e., X-ray diffractometers, and electron and atomic force microscopes. The last few decades have witnessed the accumulation of results obtained from X-ray scattering (diffraction), spectroscopy (including polarisation analysis), and imaging (including ptychography and tomography). The current article presents a multi-disciplinary review of nearly 40 years of discoveries and advancements, primarily pertaining to the study of enamel and its demineralisation (caries), but also linked to the investigations of other mineralised tissues such as dentine, bone, etc. The modelling approaches informed by these observations are also overviewed. The strategic aim of the present review was to identify and evaluate prospective avenues for analysing dental tissues and developing treatments and prophylaxis for improved dental health.

show abstract

Section: Demineralisation and Remineralisation Of Teethmentioning

confidence: 99%

Synchrotron X-ray Studies of the Structural and Functional Hierarchies in Mineralised Human Dental Enamel: A State-of-the-Art Review

et al. 2023

View full text Add to dashboard Cite

show abstract

“…For instance, the outermost layer of tooth enamel is composed of parallelly arranged hexagonal prisms and amorphous intergranular phases, which have ultrahigh viscoelasticity, and the viscoelastic figure of merit (VFOM, defined as the product of the storage modulus and the damping coefficient) was as high as 3.92 GPa, which is about 6 times higher than the limitation of traditional engineering materials (0.6 GPa). 468 The amorphous intergranular phase and the parallelly arranged structure are the key to this high viscoelasticity. Inspired by the function of the amorphous phase in enamel, Guo et al designed a wet-chemical method for controllably growing an amorphous ZrO 2 ceramic layer on damaged enamel surface.…”

Section: Excellent Plasticitymentioning

confidence: 99%

“…The characteristics of short-range order and long-range disorder of amorphous materials just satisfy the structural characteristics of both viscosity and elasticity. For instance, the outermost layer of tooth enamel is composed of parallelly arranged hexagonal prisms and amorphous intergranular phases, which have ultrahigh viscoelasticity, and the viscoelastic figure of merit (VFOM, defined as the product of the storage modulus and the damping coefficient) was as high as 3.92 GPa, which is about 6 times higher than the limitation of traditional engineering materials (0.6 GPa) . The amorphous intergranular phase and the parallelly arranged structure are the key to this high viscoelasticity.…”

Section: Applications Of Amorphous Nanomaterialsmentioning

confidence: 99%

Recent Progress of Amorphous Nanomaterials

Kang

Yang

et al. 2023

Chem. Rev.

Self Cite

View full text Add to dashboard Cite

Amorphous materials are metastable solids with only short-range order at the atomic scale, which results from local intermolecular chemical bonding. The lack of long-range order typical of crystals endows amorphous nanomaterials with unconventional and intriguing structural features, such as isotropic atomic environments, abundant surface dangling bonds, highly unsaturated coordination, etc. Because of these features and the ensuing modulation in electronic properties, amorphous nanomaterials display potential for practical applications in different areas. Motivated by these elements, here we provide an overview of the unique structural features, the general synthetic methods, and the potential for applications covered by contemporary research in amorphous nanomaterials. Furthermore, we discussed the possible theoretical mechanism for amorphous nanomaterials, examining how the unique structural properties and electronic configurations contribute to their exceptional performance. In particular, the structural benefits of amorphous nanomaterials as well as their enhanced electrocatalytic, optical, and mechanical properties, thereby clarifying the structure−function relationships, are highlighted. Finally, a perspective on the preparation and utilization of amorphous nanomaterials to establish mature systems with a superior hierarchy for various applications is introduced, and an outlook for future challenges and opportunities at the frontiers of this rapidly advancing field is proposed.

show abstract

“…The presence of organic proteins and Na and Mg increases the fracture toughness of enamel, which is a function of the distance between dentin and enamel. Mg-calcium phosphate is the main phase of AIP at the grain boundary for strengthening the interfacial connections between mineral nanofibers and improving energy dissipation [ 57 ].…”

Section: Tooth Diversitymentioning

confidence: 99%

Tooth Diversity Underpins Future Biomimetic Replications

2023

View full text Add to dashboard Cite

Although the evolution of tooth structure seems highly conserved, remarkable diversity exists among species due to different living environments and survival requirements. Along with the conservation, this diversity of evolution allows for the optimized structures and functions of teeth under various service conditions, providing valuable resources for the rational design of biomimetic materials. In this review, we survey the current knowledge about teeth from representative mammals and aquatic animals, including human teeth, herbivore and carnivore teeth, shark teeth, calcite teeth in sea urchins, magnetite teeth in chitons, and transparent teeth in dragonfish, to name a few. The highlight of tooth diversity in terms of compositions, structures, properties, and functions may stimulate further efforts in the synthesis of tooth-inspired materials with enhanced mechanical performance and broader property sets. The state-of-the-art syntheses of enamel mimetics and their properties are briefly covered. We envision that future development in this field will need to take the advantage of both conservation and diversity of teeth. Our own view on the opportunities and key challenges in this pathway is presented with a focus on the hierarchical and gradient structures, multifunctional design, and precise and scalable synthesis.

show abstract

Role of Inorganic Amorphous Constituents in Highly Mineralized Biomaterials and Their Imitations

Cited by 16 publications

References 92 publications

Synchrotron X-ray Studies of the Structural and Functional Hierarchies in Mineralised Human Dental Enamel: A State-of-the-Art Review

Synchrotron X-ray Studies of the Structural and Functional Hierarchies in Mineralised Human Dental Enamel: A State-of-the-Art Review

Recent Progress of Amorphous Nanomaterials

Tooth Diversity Underpins Future Biomimetic Replications

Contact Info

Product

Resources

About