Role of Inhalant Allergens in Atopic Eczema

Platts-Mills, Thomas A.E.; Chapman, Martin D.; Mitchell, Brett G; Heymann, Peter W.; Deuell, B.

doi:10.1007/978-3-662-02671-7_21

Cited by 23 publications

(15 citation statements)

References 50 publications

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“…A further 20 out of 23 patients improved within 10 days of admission to hospital without changing their medical treatment. Hospitalization for up to 2 weeks resulted in 'dramatic improvement' of 13/16 patients [164]: the Der p I concentrations in 15/16 patients' beds were > 10 /ig/g, whereas in hospital beds they were <0-2 //g/g. Adinoff e?…”

Section: Atopic Dermatitismentioning

confidence: 97%

See 1 more Smart Citation

The control of allergens of dust mites and domestic pets: a position paper

Colloff

Ayres²,

Carswell

et al. 1992

Clin Experimental Allergy

236

112

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Section: Atopic Dermatitismentioning

confidence: 97%

“…The above studies were all uncontrolled, and with one exception [164] did not involve mite or allergen monitoring, and patient groups contained both mite-sensitive adults and children. Case reports of five adults whose homes had been treated with Acarosan showed 70-90% improvement in symptoms [146].…”

Section: Atopic Dermatitismentioning

confidence: 99%

The control of allergens of dust mites and domestic pets: a position paper

Colloff

Ayres²,

Carswell

et al. 1992

Clin Experimental Allergy

236

112

View full text Add to dashboard Cite

“…Approximately 80% of patients with AD have elevated levels of serum IgE and evidence of IgE antibody to a variety of food and inhaled allergens (7). Well-controlled studies have demonstrated that food allergens can exacerbate skin rashes in a subset of patients with AD (8).…”

Section: Introductionmentioning

confidence: 99%

Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice.

Spergel

Mizoguchi²,

Brewer³

et al. 1998

J. Clin. Invest.

577

575

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Our understanding of the pathogenesis of atopic dermatitis (AD) and its relationship to asthma remains incomplete. Herein, we describe a murine model of epicutaneous (EC) sensitization to the protein allergen, chicken egg albumin, ovalbumin (OVA), which results in a rise in total and OVAspecific serum IgE and leads to the development of a dermatitis characterized by infiltration of CD3 ϩ T cells, eosinophils, and neutrophils and by local expression of mRNA for the cytokines IL-4, IL-5, and interferon-␥ . A single exposure of the EC sensitized mice to aerosolized OVA induced eosinophilia in the bronchoalveolar lavage fluid and airway hyperresponsiveness to intravenous methacholine as assessed by measurement of pulmonary dynamic compliance (C dyn ). These results suggest a possible role for EC exposure to antigen in atopic dermatitis and in the development of allergic asthma. (

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“…Tierhaaren, Pollen oder Hausstaubmilben, angeben und nach geeigneten Meidungsstrategien Besserung zeigen [32]. Tierhaaren, Pollen oder Hausstaubmilben, angeben und nach geeigneten Meidungsstrategien Besserung zeigen [32].…”

Section: Atopie-patch-test (Apt) Klinische Relevanzunclassified

Allergie und atopisches Ekzem: Zur Bedeutung des „Atopie-Patch-Tests”

1997

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The role of allergic reactions in eliciting and maintaining atopic eczema (AE) is still controversial. In a subgroup of patients with atopic eczema, exacerbations of itching and eczematous skin lesions have been described after contract with aeroallergens. To investigate this observation, an epicutaneous patch test with IgE-inducing allergens (atopy patch test, APT) has been proposed, which results in eczematous skin reactions in 30-70% of AE patients. Usage of allergen concentrations exceeding 5000 PNU/g in petrolatum allows testing on clinically uninvolved skin without potentially irritating epidermal tape stripping. The clinical relevance of positive APT reactions is suggested by comparison of APT with skin prick test, specific IgE, patient's history and eczema pattern. Patients with an eczema pattern with preferred localization of skin lesions in air-exposed areas, a predictive history and raised specific IgE (depending on allergen) were shown to have the highest rate of positive APT. Future controlled studies with allergen avoidance and reexposition may focus on this patient group.

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Role of Inhalant Allergens in Atopic Eczema

Cited by 23 publications

References 50 publications

The control of allergens of dust mites and domestic pets: a position paper

The control of allergens of dust mites and domestic pets: a position paper

Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice.

Allergie und atopisches Ekzem: Zur Bedeutung des „Atopie-Patch-Tests”

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