Role of Influenza Vaccination in the Elderly during an Epidemic of A/H1N1 Virus in 1988–1989: Clinical and Serological Data

Odelin, M; Pozzetto, Bruno; Aymard, M.; Defayolle, M; Jolly-Million, J.

doi:10.1159/000213520

Cited by 50 publications

(22 citation statements)

References 5 publications

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“…Vaccinated patients were significantly less likely to be infected with influenza (Table 2). This finding corroborates the results of previous studies (6,8,(10)(11)(12)24). Since the effect of influenza vaccination on infection was evaluated after controlling for the effects of variables such as patient age, gender, and ADL category, the net impact of vaccination was highly positive.…”

Section: Discussionsupporting

confidence: 90%

“…In studies evaluating parameters of vaccine efficacy, such as morbidity (6,7), mortality (6,7), hospitalization rate (8)(9)(10), and side-effects (6), influenza vaccination of elderly subjects was reported to be effective (6,7,(9)(10)(11)(12)(13). Furthermore, several studies showed no significant differences between healthy and frail elderly patients with respect to the induction of antibody responses following influenza vaccination (10,12,13).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, several studies showed no significant differences between healthy and frail elderly patients with respect to the induction of antibody responses following influenza vaccination (10,12,13). Economic impact studies also revealed that influenza vaccination was efficient in elderly patients with circulatory (2) or chronic diseases, such as asthma and diabetes mellitus (14,15), and in-patients residing in nursing hospitals (2).…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Influenza Vaccine among Elderly Patients by Physical Activity Status

Hara

Hagihara

Ikematu

et al. 2002

Environ. Health Prev. Med.

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Objective: Although many studies have shown the usefulness of influenza vaccine in elderly in-patients, the efficacy of vaccination with regard to the daily physical activities of patients has not been fully evaluated. To address this issue, we correlated the use of medical resources with vaccination status in patients categorized according to their daily activity levels.Methods: The subjects comprised 237 in-patients at or above 51 years of age, who were hospitalized in the long-term care unit of a Japanese hospital between January and March, 1999. The vaccination status and medical resources use (i.e., oral antibiotics, injected antibiotics, blood cell count, chest X-ray) of each patient were recorded, and the patients were assigned to three subgroups, based on daily life activity scores.Results: Vaccinated in-patients in the 'bed-bound' category required fewer medical resources, i.e., oral antibiotics (-2.29 days, P<0.05), injected antibiotics (-5.02 days, P<0.001), blood cell counts (-4.66 times, P<0.001), and chest X-rays (-4.31 times, P<0.001), compared with unvaccinated in-patients. There were no significant differences in treatment parameters between vaccinated and unvaccinated patients in the 'partly limited' or 'no limitation' categories.Conclusions: It is suggested that influenza vaccination significantly reduces the need for medical treatment only among those in-patients who are the least physically active. Further studies are required to replicate these findings, and to elucidate the underlying reasons for this reduction.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficacy of Influenza Vaccine among Elderly Patients by Physical Activity Status

Hara

Hagihara

Ikematu

et al. 2002

Environ. Health Prev. Med.

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“…The influenza strains included in the trivalent vaccine are listed in table 1 by year of vaccination. Radial haemolysis assay [14] was performed on serum samples drawn on the day of vaccination and 1 month later to determine the level of humoral immunity directed against the three strains included in the vaccine of the year. The humoral response was considered positive when the haemolysis diameter was 63.5 mm.…”

Section: Influenza Vaccination and Antibody Testingmentioning

confidence: 99%

Temporal Surveillance of the Humoral Immunity against Influenza Vaccine in the Elderly over 9 Consecutive Years

Odelin¹,

Momplot²,

Bourlet³

et al. 2003

Gerontology

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Background: The effect of age on declining immunity is well established, but its influence on humoral responses to influenza vaccines is still debated. Objective: To compare prospectively the immunogenicity of an influenza vaccine in elderly and healthy control subjects and to search for correlations between this specific humoral protection and clinical and virological parameters. Methods: A prospective study of the humoral response to influenza vaccine was conducted over 9 consecutive years in the long-term care units of the Saint-Etienne University Hospital, France. Antibodies directed against the vaccinal strains in an inactivated trivalent vaccine were tested by radial haemolysis before and 1 month after 477 and 242 cumulative annual vaccinations in elderly people and in healthy controls, respectively. During the last 6 years of the study, clinical samples from patients with fever ≧38°C were tested systematically for the diagnosis of an influenza infection. Results: A significant rise in anti-A/H3N2 antibody titres was observed in 49.3% of the elderly subjects and in 48.3% of the controls (not significant). The rises for the A/H1N1 and B strains were 31.4 and 39.2% (p < 0.001) and 30.6 and 40.5 (p < 0.001), respectively. When control subjects under 31 years old were excluded, no significant difference was recorded for any strain. Only 3.9% of the vaccinated elderly experienced any clinical influenza infection as defined by fever ≧38°C and virological proof. Conclusions: The humoral response to influenza immunization is not impaired in the elderly compared with middle-aged controls, and the incidence of febrile episodes due to influenza is low in this vaccinated elderly population. These findings provide further evidence supporting the recommendation for annual influenza vaccination in the elderly.

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“…Vaccination of HCWs has been shown to reduce serologically confirmed influenza and influenza-like illness among the workers, as well as total mortality in the patients for whom they care (10,(17)(18)(19). A randomized, double-blind, controlled trial was conducted over three successive epidemic seasons to determine the effectiveness of influenza vaccine given to health care professionals working in two American, acute care, urban teaching hospitals.…”

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confidence: 99%

Influenza Vaccinationfor Health Care Workers: A Duty of Care

Orr

2000

Canadian Journal of Infectious Diseases and Medical Microbiolog

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The medical literature has amply documented the transmission of influenza from patients to health care workers (HCWs) (1,2), from HCWs to patients (3) and between HCWs (4-9). The consequences of influenza transmission within the health care environment include morbidity and mortality among patients, most of who are at high risk for the complications of infection, and illness and absenteeism among health care providers. When outbreaks occur in health care facilities, absenteeism among HCWs may approach 30% to 40%, resulting in severe staff shortages, increased employment costs and the potential endangerment of health care delivery due to the scarcity of replacement workers (10-13).

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Role of Influenza Vaccination in the Elderly during an Epidemic of A/H1N1 Virus in 1988–1989: Clinical and Serological Data

Cited by 50 publications

References 5 publications

Efficacy of Influenza Vaccine among Elderly Patients by Physical Activity Status

Efficacy of Influenza Vaccine among Elderly Patients by Physical Activity Status

Temporal Surveillance of the Humoral Immunity against Influenza Vaccine in the Elderly over 9 Consecutive Years

Influenza Vaccinationfor Health Care Workers: A Duty of Care

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